Biomarkers of lymphatic function and disease: state of the art and future directions.
Identifieur interne : 002847 ( Ncbi/Curation ); précédent : 002846; suivant : 002848Biomarkers of lymphatic function and disease: state of the art and future directions.
Auteurs : Kenta Nakamura [États-Unis] ; Stanley G. RocksonSource :
- Molecular diagnosis & therapy [ 1177-1062 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Humains, Lymphangiogenèse (physiologie), Lymphoedème (anatomopathologie), Maladies lymphatiques (anatomopathologie), Maladies lymphatiques (physiopathologie), Marqueurs biologiques (métabolisme), Système lymphatique (anatomie et histologie), Système lymphatique (embryologie), Système lymphatique (physiologie), Système lymphatique (physiopathologie).
- MESH :
- anatomie et histologie : Système lymphatique.
- anatomopathologie : Lymphoedème, Maladies lymphatiques.
- embryologie : Système lymphatique.
- métabolisme : Marqueurs biologiques.
- physiologie : Lymphangiogenèse, Système lymphatique.
- physiopathologie : Maladies lymphatiques, Système lymphatique.
- Animaux, Humains.
English descriptors
- KwdEn :
- Animals, Biomarkers (metabolism), Humans, Lymphangiogenesis (physiology), Lymphatic Diseases (pathology), Lymphatic Diseases (physiopathology), Lymphatic System (anatomy & histology), Lymphatic System (embryology), Lymphatic System (physiology), Lymphatic System (physiopathology), Lymphedema (pathology).
- MESH :
- chemical , metabolism : Biomarkers.
- anatomy & histology : Lymphatic System.
- embryology : Lymphatic System.
- pathology : Lymphatic Diseases, Lymphedema.
- physiology : Lymphangiogenesis, Lymphatic System.
- physiopathology : Lymphatic Diseases, Lymphatic System.
- Animals, Humans.
Abstract
Substantial advances have accrued over the last decade in the identification of the processes that contribute to lymphatic vascular development in health and disease. Identification of distinct regulatory milestones, from a variety of genetic models, has led to a stepwise chronology of lymphatic development. Several molecular species have been identified as important tissue biomarkers of lymphatic development and function. At present, vascular endothelial growth-factor receptor (VEGFR)-3/VEGF-C/VEGF-D signaling has proven useful in the identification of clinical lymphatic metastatic potential and the assessment of cancer prognosis. Similar biomarkers, to be utilized as surrogates for the assessment of inherited and acquired diseases of the lymphatic circulation, are actively sought, and will represent a signal advance in biomedical investigation.
PubMed: 17705577
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pubmed:17705577Le document en format XML
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<term>Humans</term>
<term>Lymphangiogenesis (physiology)</term>
<term>Lymphatic Diseases (pathology)</term>
<term>Lymphatic Diseases (physiopathology)</term>
<term>Lymphatic System (anatomy & histology)</term>
<term>Lymphatic System (embryology)</term>
<term>Lymphatic System (physiology)</term>
<term>Lymphatic System (physiopathology)</term>
<term>Lymphedema (pathology)</term>
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<term>Humains</term>
<term>Lymphangiogenèse (physiologie)</term>
<term>Lymphoedème (anatomopathologie)</term>
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<term>Système lymphatique (physiologie)</term>
<term>Système lymphatique (physiopathologie)</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term>
<term>Maladies lymphatiques</term>
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<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lymphatic System</term>
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<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Système lymphatique</term>
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<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic System</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Marqueurs biologiques</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Diseases</term>
<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term>
<term>Système lymphatique</term>
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<term>Système lymphatique</term>
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<term>Lymphatic System</term>
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<front><div type="abstract" xml:lang="en">Substantial advances have accrued over the last decade in the identification of the processes that contribute to lymphatic vascular development in health and disease. Identification of distinct regulatory milestones, from a variety of genetic models, has led to a stepwise chronology of lymphatic development. Several molecular species have been identified as important tissue biomarkers of lymphatic development and function. At present, vascular endothelial growth-factor receptor (VEGFR)-3/VEGF-C/VEGF-D signaling has proven useful in the identification of clinical lymphatic metastatic potential and the assessment of cancer prognosis. Similar biomarkers, to be utilized as surrogates for the assessment of inherited and acquired diseases of the lymphatic circulation, are actively sought, and will represent a signal advance in biomedical investigation.</div>
</front>
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