The natural history of Noonan syndrome: a long‐term follow‐up study
Identifieur interne : 002412 ( Ncbi/Curation ); précédent : 002411; suivant : 002413The natural history of Noonan syndrome: a long‐term follow‐up study
Auteurs : A C Shaw ; K. Kalidas ; A H Crosby ; S. Jeffery ; M A PattonSource :
- Archives of Disease in Childhood [ 0003-9888 ] ; 2006.
Abstract
To define better the adult phenotype and natural history of Noonan syndrome.
A prospective observational study of a large cohort.
Data are presented for 112 individuals with Noonan syndrome (mean age 25.3 (range 12–71) years), who were followed up for a mean of 12.02 years. Mutations in
Although the morbidity for some patients with Noonan syndrome is low, early predictors of poorer outcome have been identified, which will help ascertain those most in need of intervention.
Url:
DOI: 10.1136/adc.2006.104547
PubMed: 16990350
PubMed Central: 2083343
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