Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status.
Identifieur interne : 002307 ( Ncbi/Curation ); précédent : 002306; suivant : 002308Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status.
Auteurs : P. Esterre [Polynésie française] ; C. Plichart ; M O Huin-Blondey ; L N Nguyen ; D. Hartmann ; S. Guerret ; C M Reimert ; S. Ricard-BlumSource :
- Parasite (Paris, France) [ 1252-607X ] ; 2006.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Facteurs immunologiques (sang), Femelle, Fibrose, Filariose lymphatique (anatomopathologie), Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Filarioses (anatomopathologie), Filarioses (parasitologie), Filarioses (sang), Humains, Marqueurs biologiques (sang), Mâle, Neurotoxine dérivée des éosinophiles (sang), Polynésie, Protéine cationique de l'éosinophile (sang), Test ELISA, Wuchereria bancrofti (immunologie).
- MESH :
- anatomopathologie : Filariose lymphatique, Filarioses.
- immunologie : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique, Filarioses.
- sang : Facteurs immunologiques, Filariose lymphatique, Filarioses, Marqueurs biologiques, Neurotoxine dérivée des éosinophiles, Protéine cationique de l'éosinophile.
- Adulte, Adulte d'âge moyen, Animaux, Femelle, Fibrose, Humains, Mâle, Polynésie, Test ELISA.
English descriptors
- KwdEn :
- Adult, Animals, Biomarkers (blood), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Enzyme-Linked Immunosorbent Assay, Eosinophil Cationic Protein (blood), Eosinophil-Derived Neurotoxin (blood), Female, Fibrosis, Filariasis (blood), Filariasis (parasitology), Filariasis (pathology), Humans, Immunologic Factors (blood), Male, Middle Aged, Polynesia, Wuchereria bancrofti (immunology).
- MESH :
- chemical , blood : Biomarkers, Eosinophil Cationic Protein, Eosinophil-Derived Neurotoxin, Immunologic Factors.
- geographic : Polynesia.
- blood : Elephantiasis, Filarial, Filariasis.
- immunology : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial, Filariasis.
- pathology : Elephantiasis, Filarial, Filariasis.
- Adult, Animals, Enzyme-Linked Immunosorbent Assay, Female, Fibrosis, Humans, Male, Middle Aged.
Abstract
We measured the concentrations of several circulating fibrosis markers (type I collagen I, type III procollagen, hyaluronan) and eosinophil granule proteins (ECP and EPX) in lymphatic filariosis patients to investigate their relationship with clinical, parasitological and immunological data. This study was conducted in Polynesian patients with various stages of the disease (acute lymphangitis, chyluria, hydrocoele, elephantiasis), a closely related microbial lymphangitis and endemic controls. We observed modifications of the different markers in this pathology. Serum type I collagen and PIIINP were decreased. Serum hyaluronan, linked to perilymphatic granulomatous inflammation, was significantly increased in acute lymphangitis and elephantiasis patients. Serum ECP was also increased, at the limit of significance in our sample, in elephantiasis patients. These two last markers, already validated in another helminth disease, schistosomiasis, have potential interest in terms of follow-up of morbidity in these parasitic diseases.
DOI: 10.1051/parasite/2006132165
PubMed: 16800126
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Esterre</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Unit, Institut de recherches médicales Malardé, Papeete, Tahiti, French Polynesia. pesterre@pasteur-cayenne.fr</nlm:affiliation><country xml:lang="fr">Polynésie française</country><wicri:regionArea>Immunology Unit, Institut de recherches médicales Malardé, Papeete, Tahiti</wicri:regionArea><wicri:noRegion>Tahiti</wicri:noRegion></affiliation></author><author><name sortKey="Plichart, C" sort="Plichart, C" uniqKey="Plichart C" first="C" last="Plichart">C. Plichart</name></author><author><name sortKey="Huin Blondey, M O" sort="Huin Blondey, M O" uniqKey="Huin Blondey M" first="M O" last="Huin-Blondey">M O Huin-Blondey</name></author><author><name sortKey="Nguyen, L N" sort="Nguyen, L N" uniqKey="Nguyen L" first="L N" last="Nguyen">L N Nguyen</name></author><author><name sortKey="Hartmann, D" sort="Hartmann, D" uniqKey="Hartmann D" first="D" last="Hartmann">D. Hartmann</name></author><author><name sortKey="Guerret, S" sort="Guerret, S" uniqKey="Guerret S" first="S" last="Guerret">S. Guerret</name></author><author><name sortKey="Reimert, C M" sort="Reimert, C M" uniqKey="Reimert C" first="C M" last="Reimert">C M Reimert</name></author><author><name sortKey="Ricard Blum, S" sort="Ricard Blum, S" uniqKey="Ricard Blum S" first="S" last="Ricard-Blum">S. 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This study was conducted in Polynesian patients with various stages of the disease (acute lymphangitis, chyluria, hydrocoele, elephantiasis), a closely related microbial lymphangitis and endemic controls. We observed modifications of the different markers in this pathology. Serum type I collagen and PIIINP were decreased. Serum hyaluronan, linked to perilymphatic granulomatous inflammation, was significantly increased in acute lymphangitis and elephantiasis patients. Serum ECP was also increased, at the limit of significance in our sample, in elephantiasis patients. These two last markers, already validated in another helminth disease, schistosomiasis, have potential interest in terms of follow-up of morbidity in these parasitic diseases.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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