LymphedemaV1, Ncbi, Curation, bibRecord, 002134

Large-scale identification of genes implicated in kidney glomerulus development and function

Identifieur interne : 002134 ( Ncbi/Curation ); précédent : 002133; suivant : 002135

Large-scale identification of genes implicated in kidney glomerulus development and function

Auteurs : Minoru Takemoto [Suède] ; Liqun He [Suède] ; Jenny Norlin [Suède] ; Jaakko Patrakka [Suède] ; Zhijie Xiao [Suède] ; Tatiana Petrova [Finlande] ; Cecilia Bondjers [Suède] ; Julia Asp [Suède] ; Elisabet Wallgard [Suède] ; Ying Sun [Suède] ; Tore Samuelsson [Suède] ; Petter Mostad [Suède] ; Samuel Lundin [Suède] ; Naoyuki Miura [Japon] ; Yoshikazu Sado [Japon] ; Kari Alitalo [Finlande] ; Susan E. Quaggin [Canada] ; Karl Tryggvason [Suède] ; Christer Betsholtz [Suède]

Source :

The EMBO Journal [ 0261-4189 ] ; 2006.

RBID : PMC:1409724

Abstract

To advance our understanding of development, function and diseases in the kidney glomerulus, we have established and large-scale sequenced cDNA libraries from mouse glomeruli at different stages of development, resulting in a catalogue of 6053 different genes. The glomerular cDNA clones were arrayed and hybridized against a series of labeled targets from isolated glomeruli, non-glomerular kidney tissue, FACS-sorted podocytes and brain capillaries, which identified over 300 glomerular cell-enriched transcripts, some of which were further sublocalized to podocytes, mesangial cells and juxtaglomerular cells by in situ hybridization. For the earliest podocyte marker identified, Foxc2, knockout mice were used to analyze the role of this protein during glomerular development. We show that Foxc2 controls the expression of a distinct set of podocyte genes involved in podocyte differentiation and glomerular basement membrane maturation. The primary podocyte defects also cause abnormal differentiation and organization of the glomerular vascular cells. We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409724

DOI: 10.1038/sj.emboj.7601014
PubMed: 16498405
PubMed Central: 1409724

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PMC:1409724

Le document en format XML

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<author><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name>
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<author><name sortKey="Asp, Julia" sort="Asp, Julia" uniqKey="Asp J" first="Julia" last="Asp">Julia Asp</name>
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<author><name sortKey="Sun, Ying" sort="Sun, Ying" uniqKey="Sun Y" first="Ying" last="Sun">Ying Sun</name>
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<author><name sortKey="Samuelsson, Tore" sort="Samuelsson, Tore" uniqKey="Samuelsson T" first="Tore" last="Samuelsson">Tore Samuelsson</name>
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<author><name sortKey="Mostad, Petter" sort="Mostad, Petter" uniqKey="Mostad P" first="Petter" last="Mostad">Petter Mostad</name>
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<author><name sortKey="Lundin, Samuel" sort="Lundin, Samuel" uniqKey="Lundin S" first="Samuel" last="Lundin">Samuel Lundin</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Microbiology and Immunology, Göteborg University, Göteborg</wicri:regionArea>
<orgName type="university">Université de Göteborg</orgName>
<placeName><settlement type="city">Göteborg</settlement>
<region nuts="1">Götaland</region>
<region nuts="1">Suède occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name>
<affiliation wicri:level="1"><nlm:aff id="O7">Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu</wicri:regionArea>
<wicri:noRegion>Hamamatsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sado, Yoshikazu" sort="Sado, Yoshikazu" uniqKey="Sado Y" first="Yoshikazu" last="Sado">Yoshikazu Sado</name>
<affiliation wicri:level="1"><nlm:aff id="O8">Division of Immunology, Shigei Medical Research Institute, Okayama, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Immunology, Shigei Medical Research Institute, Okayama</wicri:regionArea>
<wicri:noRegion>Okayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation wicri:level="4"><nlm:aff id="O9">Molecular/Cancer Biology Laboratory, Biomedicum, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Molecular/Cancer Biology Laboratory, Biomedicum, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Quaggin, Susan E" sort="Quaggin, Susan E" uniqKey="Quaggin S" first="Susan E" last="Quaggin">Susan E. Quaggin</name>
<affiliation wicri:level="4"><nlm:aff id="O10">Department of Maternal and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Maternal and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tryggvason, Karl" sort="Tryggvason, Karl" uniqKey="Tryggvason K" first="Karl" last="Tryggvason">Karl Tryggvason</name>
<affiliation wicri:level="3"><nlm:aff id="O1">Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Betsholtz, Christer" sort="Betsholtz, Christer" uniqKey="Betsholtz C" first="Christer" last="Betsholtz">Christer Betsholtz</name>
<affiliation wicri:level="3"><nlm:aff id="O1">Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="O11">Department of Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The EMBO Journal</title>
<idno type="ISSN">0261-4189</idno>
<idno type="eISSN">1460-2075</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>To advance our understanding of development, function and diseases in the kidney glomerulus, we have established and large-scale sequenced cDNA libraries from mouse glomeruli at different stages of development, resulting in a catalogue of 6053 different genes. The glomerular cDNA clones were arrayed and hybridized against a series of labeled targets from isolated glomeruli, non-glomerular kidney tissue, FACS-sorted podocytes and brain capillaries, which identified over 300 glomerular cell-enriched transcripts, some of which were further sublocalized to podocytes, mesangial cells and juxtaglomerular cells by <italic>in situ</italic>
 hybridization. For the earliest podocyte marker identified, Foxc2, knockout mice were used to analyze the role of this protein during glomerular development. We show that Foxc2 controls the expression of a distinct set of podocyte genes involved in podocyte differentiation and glomerular basement membrane maturation. The primary podocyte defects also cause abnormal differentiation and organization of the glomerular vascular cells. We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease.</p>
</div>
</front>
</TEI>
</record>

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Large-scale identification of genes implicated in kidney glomerulus development and function

Large-scale identification of genes implicated in kidney glomerulus development and function

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