Animal models for the study of lymphatic insufficiency.
Identifieur interne : 001C62 ( Ncbi/Curation ); précédent : 001C61; suivant : 001C63Animal models for the study of lymphatic insufficiency.
Auteurs : William S. Shin [États-Unis] ; Andrzej Szuba ; Stanley G. RocksonSource :
- Lymphatic research and biology [ 1539-6851 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
Lymphedema is the term commonly employed to describe the spectrum of pathological states that arise as a consequence of functional lymphatic insufficiency. These human disease entities currently lack an effective cure. Satisfactory therapeutic strategies for both primary and secondary lymphedema will require additional insight into the complex cellular mechanisms and responses that comprise both normal lymphatic function and its regional derangement in states of pathologic dysfunction. Such insights must, initially, be derived from suitable animal models of the chronic human disease process. Historically, efforts to replicate the untreated disease of human lymphedema in animals, through surgery, irradiation, and toxicology, have been fraught with difficulty. The major impediments to the creation of satisfactory animal models have included an inability to reproduce the chronic disease in a stable, reproducible format. Recently, with the promise of potentially successful growth factor-mediated therapeutic lymphangiogenesis, and with the enhanced availability of investigative tools to assess therapeutic responses to molecular therapies, there has been a resurgence of interest in the development of viable animal models of lymphatic insufficiency. Current research has led to the development of genetic and postsurgical models of lymphedema that closely simulate the human conditions of primary and secondary lymphatic insufficiency, respectively. Such models will help to refine the assessment of various therapeutic approaches and their potential applicability to human disease interventions.
DOI: 10.1089/153968503321642642
PubMed: 15624423
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003E16
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003E16
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003E16
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001C62
Links to Exploration step
pubmed:15624423Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Animal models for the study of lymphatic insufficiency.</title><author><name sortKey="Shin, William S" sort="Shin, William S" uniqKey="Shin W" first="William S" last="Shin">William S. Shin</name><affiliation wicri:level="1"><nlm:affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Szuba, Andrzej" sort="Szuba, Andrzej" uniqKey="Szuba A" first="Andrzej" last="Szuba">Andrzej Szuba</name></author><author><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G" last="Rockson">Stanley G. Rockson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:15624423</idno><idno type="pmid">15624423</idno><idno type="doi">10.1089/153968503321642642</idno><idno type="wicri:Area/PubMed/Corpus">003E16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003E16</idno><idno type="wicri:Area/PubMed/Curation">003E16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003E16</idno><idno type="wicri:Area/PubMed/Checkpoint">003E16</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003E16</idno><idno type="wicri:Area/Ncbi/Merge">001C62</idno><idno type="wicri:Area/Ncbi/Curation">001C62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Animal models for the study of lymphatic insufficiency.</title><author><name sortKey="Shin, William S" sort="Shin, William S" uniqKey="Shin W" first="William S" last="Shin">William S. Shin</name><affiliation wicri:level="1"><nlm:affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Szuba, Andrzej" sort="Szuba, Andrzej" uniqKey="Szuba A" first="Andrzej" last="Szuba">Andrzej Szuba</name></author><author><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G" last="Rockson">Stanley G. Rockson</name></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="ISSN">1539-6851</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Lymphangiogenesis</term><term>Lymphatic Diseases (pathology)</term><term>Lymphatic System (pathology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Lymphangiogenèse</term><term>Lymphoedème (anatomopathologie)</term><term>Maladies lymphatiques (anatomopathologie)</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Système lymphatique (anatomopathologie)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Maladies lymphatiques</term><term>Noeuds lymphatiques</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term><term>Lymphatic Diseases</term><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Lymphangiogenèse</term><term>Modèles animaux de maladie humaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema is the term commonly employed to describe the spectrum of pathological states that arise as a consequence of functional lymphatic insufficiency. These human disease entities currently lack an effective cure. Satisfactory therapeutic strategies for both primary and secondary lymphedema will require additional insight into the complex cellular mechanisms and responses that comprise both normal lymphatic function and its regional derangement in states of pathologic dysfunction. Such insights must, initially, be derived from suitable animal models of the chronic human disease process. Historically, efforts to replicate the untreated disease of human lymphedema in animals, through surgery, irradiation, and toxicology, have been fraught with difficulty. The major impediments to the creation of satisfactory animal models have included an inability to reproduce the chronic disease in a stable, reproducible format. Recently, with the promise of potentially successful growth factor-mediated therapeutic lymphangiogenesis, and with the enhanced availability of investigative tools to assess therapeutic responses to molecular therapies, there has been a resurgence of interest in the development of viable animal models of lymphatic insufficiency. Current research has led to the development of genetic and postsurgical models of lymphedema that closely simulate the human conditions of primary and secondary lymphatic insufficiency, respectively. Such models will help to refine the assessment of various therapeutic approaches and their potential applicability to human disease interventions.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001C62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:15624423
|texte= Animal models for the study of lymphatic insufficiency.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:15624423" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |