LymphedemaV1, Ncbi, Curation, bibRecord, 001973

Impairment of Tetanus-Specific Cellular and Humoral Responses following Tetanus Vaccination in Human Lymphatic Filariasis

Identifieur interne : 001973 ( Ncbi/Curation ); précédent : 001972; suivant : 001974

Impairment of Tetanus-Specific Cellular and Humoral Responses following Tetanus Vaccination in Human Lymphatic Filariasis

Auteurs : Suba Nookala ; Sundaram Srinivasan ; Perumal Kaliraj ; Rangarajan Badri Narayanan ; Thomas B. Nutman

Source :

Infection and Immunity [ 0019-9567 ] ; 2004.

RBID : PMC:387878

Descripteurs français

KwdFr :
- Activation des lymphocytes, Adulte, Adulte d'âge moyen, Anatoxine tétanique (immunologie), Anatoxine tétanique (pharmacologie), Animaux, Anticorps antibactériens (sang), Cytokines (biosynthèse), Femelle, Filariose lymphatique (immunologie), Humains, Immunité cellulaire, Interactions hôte-parasite (immunologie), Microfilaria (immunologie), Mâle, Sujet âgé, Techniques in vitro, Tolérance immunitaire, Vaccination, Wuchereria bancrofti (immunologie), Études cas-témoins.
MESH :
- biosynthèse : Cytokines.
- immunologie : Anatoxine tétanique, Filariose lymphatique, Interactions hôte-parasite, Microfilaria, Wuchereria bancrofti.
- pharmacologie : Anatoxine tétanique.
- sang : Anticorps antibactériens.
- Activation des lymphocytes, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Immunité cellulaire, Mâle, Sujet âgé, Techniques in vitro, Tolérance immunitaire, Vaccination, Études cas-témoins.

English descriptors

KwdEn :
- Adult, Aged, Animals, Antibodies, Bacterial (blood), Case-Control Studies, Cytokines (biosynthesis), Elephantiasis, Filarial (immunology), Female, Host-Parasite Interactions (immunology), Humans, Immune Tolerance, Immunity, Cellular, In Vitro Techniques, Lymphocyte Activation, Male, Microfilariae (immunology), Middle Aged, Tetanus Toxoid (immunology), Tetanus Toxoid (pharmacology), Vaccination, Wuchereria bancrofti (immunology).
MESH :
- chemical , biosynthesis : Cytokines.
- chemical , blood : Antibodies, Bacterial.
- immunology : Elephantiasis, Filarial, Host-Parasite Interactions, Microfilariae, Tetanus Toxoid, Wuchereria bancrofti.
- chemical , pharmacology : Tetanus Toxoid.
- Adult, Aged, Animals, Case-Control Studies, Female, Humans, Immune Tolerance, Immunity, Cellular, In Vitro Techniques, Lymphocyte Activation, Male, Middle Aged, Vaccination.

Abstract

To investigate the consequences of the impaired parasite-specific immune response in lymphatic filariasis, the effect of concurrent Wuchereria bancrofti infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied in 20 asymptomatic microfilaremic (MF) patients, 20 patients with chronic lymphatic obstruction/elephantiasis (chronic pathology [CP]), and 10 endemic normal (EN) control individuals at baseline and at 3 and 6 months after TT vaccination. Peripheral blood mononuclear cell (PBMC) proliferative responses to TT before vaccination were not significantly different between the EN control and CP groups, but the MF group showed significantly lower baseline proliferative responses to TT compared with either the EN or CP group. Six months following vaccination, the change in proliferative response to TT was significantly greater in the EN and CP groups than in the MF group. This difference in proliferative response was reiterated in the gamma interferon (IFN-γ) response in the EN group, in that they increased IFN-γ production by 400% at 6 months, in contrast to that seen in the filaria-infected groups. In contrast to the IFN-γ responses, PBMCs from the MF group produced significantly increased levels of TT-specific IL-10 compared with PBMCs from the EN group. Although there was significantly greater TT-specific immunoglobulin G (IgG) production at baseline between the EN and MF groups, postvaccination IgG (and IgG1 isotype) responses did not differ among the groups, whereas TT-specific IgG2, IgG3, and IgG4 were all increased in the EN group compared with the filaria-infected groups. These studies indicate that concurrent infection with W. bancrofti can diminish the immune response to an unrelated antigen by a mechanism that is likely to involve IL-10.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387878

DOI: 10.1128/IAI.72.5.2598-2604.2004
PubMed: 15102768
PubMed Central: 387878

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PMC:387878

Le document en format XML

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<term>Case-Control Studies</term>
<term>Cytokines (biosynthesis)</term>
<term>Elephantiasis, Filarial (immunology)</term>
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<term>Anatoxine tétanique (pharmacologie)</term>
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<term>Anticorps antibactériens (sang)</term>
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<term>Microfilaria (immunologie)</term>
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<term>Sujet âgé</term>
<term>Techniques in vitro</term>
<term>Tolérance immunitaire</term>
<term>Vaccination</term>
<term>Wuchereria bancrofti (immunologie)</term>
<term>Études cas-témoins</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anatoxine tétanique</term>
<term>Filariose lymphatique</term>
<term>Interactions hôte-parasite</term>
<term>Microfilaria</term>
<term>Wuchereria bancrofti</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
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<term>Microfilariae</term>
<term>Tetanus Toxoid</term>
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<term>Aged</term>
<term>Animals</term>
<term>Case-Control Studies</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p>To investigate the consequences of the impaired parasite-specific immune response in lymphatic filariasis, the effect of concurrent <italic>Wuchereria bancrofti</italic>
 infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied in 20 asymptomatic microfilaremic (MF) patients, 20 patients with chronic lymphatic obstruction/elephantiasis (chronic pathology [CP]), and 10 endemic normal (EN) control individuals at baseline and at 3 and 6 months after TT vaccination. Peripheral blood mononuclear cell (PBMC) proliferative responses to TT before vaccination were not significantly different between the EN control and CP groups, but the MF group showed significantly lower baseline proliferative responses to TT compared with either the EN or CP group. Six months following vaccination, the change in proliferative response to TT was significantly greater in the EN and CP groups than in the MF group. This difference in proliferative response was reiterated in the gamma interferon (IFN-γ) response in the EN group, in that they increased IFN-γ production by 400% at 6 months, in contrast to that seen in the filaria-infected groups. In contrast to the IFN-γ responses, PBMCs from the MF group produced significantly increased levels of TT-specific IL-10 compared with PBMCs from the EN group. Although there was significantly greater TT-specific immunoglobulin G (IgG) production at baseline between the EN and MF groups, postvaccination IgG (and IgG1 isotype) responses did not differ among the groups, whereas TT-specific IgG2, IgG3, and IgG4 were all increased in the EN group compared with the filaria-infected groups. These studies indicate that concurrent infection with <italic>W. bancrofti</italic>
 can diminish the immune response to an unrelated antigen by a mechanism that is likely to involve IL-10.</p>
</div>
</front>
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Impairment of Tetanus-Specific Cellular and Humoral Responses following Tetanus Vaccination in Human Lymphatic Filariasis

Impairment of Tetanus-Specific Cellular and Humoral Responses following Tetanus Vaccination in Human Lymphatic Filariasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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