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Molecular regulation of lymphangiogenesis and targets for tissue oedema.

Identifieur interne : 000683 ( Ncbi/Curation ); précédent : 000682; suivant : 000684

Molecular regulation of lymphangiogenesis and targets for tissue oedema.

Auteurs : M J Karkkainen [Finlande] ; L. Jussila ; R E Ferrell ; D N Finegold ; Kari Alitalo [Finlande]

Source :

RBID : pubmed:11427983

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English descriptors

Abstract

New insight has recently been obtained into the molecular mechanisms regulating the function of lymphatic endothelial cells. Vascular endothelial growth factors-C and -D have been shown to stimulate lymphangiogenesis, and their receptor VEGFR-3 has been linked to human hereditary lymphoedema, although there is evidence that other genes are also involved. These data suggest that it may become possible to stimulate lymphatic growth and function and to treat tissue oedema involved in many diseases.

PubMed: 11427983

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pubmed:11427983

Le document en format XML

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<title level="j">Trends in molecular medicine</title>
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<term>Animals</term>
<term>Cell Membrane Permeability</term>
<term>Chromosomes, Human, Pair 16 (genetics)</term>
<term>Chromosomes, Human, Pair 5 (genetics)</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>DNA-Binding Proteins (physiology)</term>
<term>Endothelial Growth Factors (genetics)</term>
<term>Endothelial Growth Factors (physiology)</term>
<term>Endothelium (cytology)</term>
<term>Endothelium (metabolism)</term>
<term>Eyelashes (abnormalities)</term>
<term>Forecasting</term>
<term>Forkhead Transcription Factors</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Genetic Heterogeneity</term>
<term>Genetic Linkage</term>
<term>Humans</term>
<term>Lymphatic System (cytology)</term>
<term>Lymphatic System (embryology)</term>
<term>Lymphatic System (growth & development)</term>
<term>Lymphatic System (physiology)</term>
<term>Lymphedema (genetics)</term>
<term>Lymphedema (physiopathology)</term>
<term>Lymphedema (therapy)</term>
<term>Mice</term>
<term>Mice, Mutant Strains</term>
<term>Receptor Protein-Tyrosine Kinases (physiology)</term>
<term>Receptors, Growth Factor (physiology)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (physiology)</term>
<term>Turner Syndrome (genetics)</term>
<term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor D</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
<term>X Chromosome (genetics)</term>
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<term>Animaux</term>
<term>Chromosome X (génétique)</term>
<term>Chromosomes humains de la paire 16 (génétique)</term>
<term>Chromosomes humains de la paire 5 (génétique)</term>
<term>Cils (malformations)</term>
<term>Endothélium (cytologie)</term>
<term>Endothélium (métabolisme)</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Facteur de croissance endothéliale vasculaire de type D</term>
<term>Facteurs de croissance endothéliale (génétique)</term>
<term>Facteurs de croissance endothéliale (physiologie)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (physiologie)</term>
<term>Facteurs de transcription Forkhead</term>
<term>Humains</term>
<term>Hétérogénéité génétique</term>
<term>Liaison génétique</term>
<term>Lymphoedème ()</term>
<term>Lymphoedème (génétique)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Perméabilité de la membrane cellulaire</term>
<term>Protéines de liaison à l'ADN (génétique)</term>
<term>Protéines de liaison à l'ADN (physiologie)</term>
<term>Prévision</term>
<term>Récepteur facteur croissance (physiologie)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
<term>Récepteurs à activité tyrosine kinase (physiologie)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Souches mutantes de souris</term>
<term>Souris</term>
<term>Syndrome de Turner (génétique)</term>
<term>Système lymphatique (croissance et développement)</term>
<term>Système lymphatique (cytologie)</term>
<term>Système lymphatique (embryologie)</term>
<term>Système lymphatique (physiologie)</term>
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<term>DNA-Binding Proteins</term>
<term>Endothelial Growth Factors</term>
<term>Transcription Factors</term>
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<term>Eyelashes</term>
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<term>Système lymphatique</term>
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<term>Endothélium</term>
<term>Système lymphatique</term>
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<term>Endothelium</term>
<term>Lymphatic System</term>
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<term>Système lymphatique</term>
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<term>Lymphatic System</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Chromosomes, Human, Pair 16</term>
<term>Chromosomes, Human, Pair 5</term>
<term>Lymphedema</term>
<term>Turner Syndrome</term>
<term>X Chromosome</term>
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<keywords scheme="MESH" qualifier="growth & development" xml:lang="en">
<term>Lymphatic System</term>
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<term>Chromosome X</term>
<term>Chromosomes humains de la paire 16</term>
<term>Chromosomes humains de la paire 5</term>
<term>Facteurs de croissance endothéliale</term>
<term>Facteurs de transcription</term>
<term>Lymphoedème</term>
<term>Protéines de liaison à l'ADN</term>
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<term>Facteurs de croissance endothéliale</term>
<term>Facteurs de transcription</term>
<term>Protéines de liaison à l'ADN</term>
<term>Récepteur facteur croissance</term>
<term>Récepteurs à activité tyrosine kinase</term>
<term>Système lymphatique</term>
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<term>DNA-Binding Proteins</term>
<term>Endothelial Growth Factors</term>
<term>Lymphatic System</term>
<term>Receptor Protein-Tyrosine Kinases</term>
<term>Receptors, Growth Factor</term>
<term>Transcription Factors</term>
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<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Cell Membrane Permeability</term>
<term>Forecasting</term>
<term>Forkhead Transcription Factors</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Genetic Heterogeneity</term>
<term>Genetic Linkage</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Mutant Strains</term>
<term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor D</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
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<term>Animaux</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Facteur de croissance endothéliale vasculaire de type D</term>
<term>Facteurs de transcription Forkhead</term>
<term>Humains</term>
<term>Hétérogénéité génétique</term>
<term>Liaison génétique</term>
<term>Lymphoedème</term>
<term>Perméabilité de la membrane cellulaire</term>
<term>Prévision</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
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<front>
<div type="abstract" xml:lang="en">New insight has recently been obtained into the molecular mechanisms regulating the function of lymphatic endothelial cells. Vascular endothelial growth factors-C and -D have been shown to stimulate lymphangiogenesis, and their receptor VEGFR-3 has been linked to human hereditary lymphoedema, although there is evidence that other genes are also involved. These data suggest that it may become possible to stimulate lymphatic growth and function and to treat tissue oedema involved in many diseases.</div>
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