Forearm blood flow measured by venous occlusion plethysmography in healthy subjects and in women with postmastectomy oedema.
Identifieur interne : 00BC36 ( Ncbi/Checkpoint ); précédent : 00BC35; suivant : 00BC37Forearm blood flow measured by venous occlusion plethysmography in healthy subjects and in women with postmastectomy oedema.
Auteurs : A W Stanton [Royaume-Uni] ; B. Holroyd ; J W Northfield ; J R Levick ; Peter Mortimer (dermatologue) [Royaume-Uni]Source :
- Vascular medicine (London, England) [ 1358-863X ] ; 1998.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Avant-bras (), Débit sanguin régional, Femelle, Humains, Lymphoedème (physiopathologie), Lymphoedème (étiologie), Mastectomie (effets indésirables), Microcirculation, Mâle, Pléthysmographie (), Reproductibilité des résultats, Sujet âgé, Sujet âgé de 80 ans ou plus, Vitesse du flux sanguin (physiologie).
- MESH :
- effets indésirables : Mastectomie.
- physiologie : Vitesse du flux sanguin.
- physiopathologie : Lymphoedème.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Avant-bras, Débit sanguin régional, Femelle, Humains, Microcirculation, Mâle, Pléthysmographie, Reproductibilité des résultats, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Blood Flow Velocity (physiology), Female, Forearm (blood supply), Humans, Lymphedema (etiology), Lymphedema (physiopathology), Male, Mastectomy (adverse effects), Microcirculation, Middle Aged, Plethysmography (methods), Regional Blood Flow, Reproducibility of Results.
- MESH :
- adverse effects : Mastectomy.
- blood supply : Forearm.
- etiology : Lymphedema.
- methods : Plethysmography.
- physiology : Blood Flow Velocity.
- physiopathology : Lymphedema.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Microcirculation, Middle Aged, Regional Blood Flow, Reproducibility of Results.
Abstract
A chronic swelling of the arm may develop following damage to axillary lymph vessels during breast cancer treatment. Certain unusual pathophysiological features of postmastectomy oedema indicate that factors additional to lymphatic damage are important. One factor postulated previously is a haemodynamic abnormality. Forearm blood flow was therefore measured by venous occlusion plethysmography using both a conventional mercury strain gauge and a newer optical volumeter (Perometer). The latter was initially assessed in healthy subjects. When forearm blood flow was measured using the two methods simultaneously, the strain gauge and Perometer did not differ significantly for healthy or oedematous arms. Dominant and non-dominant arm blood flow in healthy subjects was similar but with greater variation between sides with the Perometer. Using the strain gauge, blood flow in the oedematous arm (2.51 +/- 1.33 ml/100 ml per min) was significantly lower than in the opposite unaffected arm (3.77 +/- 2.29 ml/100 ml per min; p = 0.026). The Perometer results showed a similar but nonsignificant trend (p = 0.105). Taking into account the greater limb volume on the affected side, total forearm blood flow was essentially the same in each arm (unaffected: 40.72 +/- 28.70 micromilligrams/min; oedematous: 41.78 +/- 22.11 ml/min). The reduced blood flow per unit volume of arm was therefore likely to be due to a simple 'dilution' effect of the increase in volume. The results indicate that it is unlikely that raised blood flow contributes to oedema formation, contrary to the haemodynamic concept.
DOI: 10.1177/1358836X9800300102
PubMed: 9666525
Affiliations:
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Holroyd</name></author><author><name sortKey="Northfield, J W" sort="Northfield, J W" uniqKey="Northfield J" first="J W" last="Northfield">J W Northfield</name></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9666525</idno><idno type="pmid">9666525</idno><idno type="doi">10.1177/1358836X9800300102</idno><idno type="wicri:Area/PubMed/Corpus">004E61</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004E61</idno><idno type="wicri:Area/PubMed/Curation">004E61</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004E61</idno><idno type="wicri:Area/PubMed/Checkpoint">004E61</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004E61</idno><idno type="wicri:Area/Ncbi/Merge">00BC36</idno><idno type="wicri:Area/Ncbi/Curation">00BC36</idno><idno type="wicri:Area/Ncbi/Checkpoint">00BC36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Forearm blood flow measured by venous occlusion plethysmography in healthy subjects and in women with postmastectomy oedema.</title><author><name sortKey="Stanton, A W" sort="Stanton, A W" uniqKey="Stanton A" first="A W" last="Stanton">A W Stanton</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, St George's Hospital School, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, St George's Hospital School, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Holroyd, B" sort="Holroyd, B" uniqKey="Holroyd B" first="B" last="Holroyd">B. Holroyd</name></author><author><name sortKey="Northfield, J W" sort="Northfield, J W" uniqKey="Northfield J" first="J W" last="Northfield">J W Northfield</name></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></analytic><series><title level="j">Vascular medicine (London, England)</title><idno type="ISSN">1358-863X</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Blood Flow Velocity (physiology)</term><term>Female</term><term>Forearm (blood supply)</term><term>Humans</term><term>Lymphedema (etiology)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Mastectomy (adverse effects)</term><term>Microcirculation</term><term>Middle Aged</term><term>Plethysmography (methods)</term><term>Regional Blood Flow</term><term>Reproducibility of Results</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Avant-bras ()</term><term>Débit sanguin régional</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (étiologie)</term><term>Mastectomie (effets indésirables)</term><term>Microcirculation</term><term>Mâle</term><term>Pléthysmographie ()</term><term>Reproductibilité des résultats</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Vitesse du flux sanguin (physiologie)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Forearm</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Plethysmography</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vitesse du flux sanguin</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Flow Velocity</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Microcirculation</term><term>Middle Aged</term><term>Regional Blood Flow</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Avant-bras</term><term>Débit sanguin régional</term><term>Femelle</term><term>Humains</term><term>Microcirculation</term><term>Mâle</term><term>Pléthysmographie</term><term>Reproductibilité des résultats</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A chronic swelling of the arm may develop following damage to axillary lymph vessels during breast cancer treatment. Certain unusual pathophysiological features of postmastectomy oedema indicate that factors additional to lymphatic damage are important. One factor postulated previously is a haemodynamic abnormality. Forearm blood flow was therefore measured by venous occlusion plethysmography using both a conventional mercury strain gauge and a newer optical volumeter (Perometer). The latter was initially assessed in healthy subjects. When forearm blood flow was measured using the two methods simultaneously, the strain gauge and Perometer did not differ significantly for healthy or oedematous arms. Dominant and non-dominant arm blood flow in healthy subjects was similar but with greater variation between sides with the Perometer. Using the strain gauge, blood flow in the oedematous arm (2.51 +/- 1.33 ml/100 ml per min) was significantly lower than in the opposite unaffected arm (3.77 +/- 2.29 ml/100 ml per min; p = 0.026). The Perometer results showed a similar but nonsignificant trend (p = 0.105). Taking into account the greater limb volume on the affected side, total forearm blood flow was essentially the same in each arm (unaffected: 40.72 +/- 28.70 micromilligrams/min; oedematous: 41.78 +/- 22.11 ml/min). The reduced blood flow per unit volume of arm was therefore likely to be due to a simple 'dilution' effect of the increase in volume. The results indicate that it is unlikely that raised blood flow contributes to oedema formation, contrary to the haemodynamic concept.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><noCountry><name sortKey="Holroyd, B" sort="Holroyd, B" uniqKey="Holroyd B" first="B" last="Holroyd">B. Holroyd</name><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name><name sortKey="Northfield, J W" sort="Northfield, J W" uniqKey="Northfield J" first="J W" last="Northfield">J W Northfield</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Stanton, A W" sort="Stanton, A W" uniqKey="Stanton A" first="A W" last="Stanton">A W Stanton</name></region><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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