Association of elevated lymph node cell release of histamine and tumor necrosis factor with genetic predisposition to limb edema formation in dogs infected with Brugia pahangi.
Identifieur interne : 00BC30 ( Ncbi/Checkpoint ); précédent : 00BC29; suivant : 00BC31Association of elevated lymph node cell release of histamine and tumor necrosis factor with genetic predisposition to limb edema formation in dogs infected with Brugia pahangi.
Auteurs : S. Orton [États-Unis] ; D. Weinstock ; B. HammerbergSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1998.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Animaux, Biopsie (médecine vétérinaire), Brugia pahangi (physiologie), Cellules cultivées, Chiens, Dinoprostone (métabolisme), Facteur de nécrose tumorale alpha (métabolisme), Femelle, Filarioses (), Filarioses (médecine vétérinaire), Filarioses (métabolisme), Histamine (métabolisme), Immunohistochimie, Lymphoedème (génétique), Lymphoedème (médecine vétérinaire), Lymphoedème (étiologie), Maladies des chiens (génétique), Maladies des chiens (métabolisme), Maladies des chiens (étiologie), Mâle, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (métabolisme), Pedigree.
- MESH :
- anatomopathologie : Noeuds lymphatiques.
- génétique : Lymphoedème, Maladies des chiens.
- médecine vétérinaire : Biopsie, Filarioses, Lymphoedème.
- métabolisme : Dinoprostone, Facteur de nécrose tumorale alpha, Filarioses, Histamine, Maladies des chiens, Noeuds lymphatiques.
- physiologie : Brugia pahangi.
- étiologie : Lymphoedème, Maladies des chiens.
- Activation des lymphocytes, Animaux, Cellules cultivées, Chiens, Femelle, Filarioses, Immunohistochimie, Mâle, Pedigree.
English descriptors
- KwdEn :
- Animals, Biopsy (veterinary), Brugia pahangi (physiology), Cells, Cultured, Dinoprostone (metabolism), Dog Diseases (etiology), Dog Diseases (genetics), Dog Diseases (metabolism), Dogs, Female, Filariasis (complications), Filariasis (metabolism), Filariasis (veterinary), Histamine (metabolism), Immunohistochemistry, Lymph Nodes (metabolism), Lymph Nodes (pathology), Lymphedema (etiology), Lymphedema (genetics), Lymphedema (veterinary), Lymphocyte Activation, Male, Pedigree, Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , metabolism : Dinoprostone, Histamine, Tumor Necrosis Factor-alpha.
- complications : Filariasis.
- etiology : Dog Diseases, Lymphedema.
- genetics : Dog Diseases, Lymphedema.
- metabolism : Dog Diseases, Filariasis, Lymph Nodes.
- pathology : Lymph Nodes.
- physiology : Brugia pahangi.
- veterinary : Biopsy, Filariasis, Lymphedema.
- Animals, Cells, Cultured, Dogs, Female, Immunohistochemistry, Lymphocyte Activation, Male, Pedigree.
Abstract
Brugia pahangi infection in the canine rear limb results in marked lymphatic duct and popliteal lymph node pathologic changes. Limb edema is variably associated with infection and does not correlate well with duct or node lesions. To understand the mechanisms of limb edema, lymph node cells were collected by sequential biopsy following infection and examined for production of inflammatory mediators. Lymph node cells from a litter of dogs selectively bred with a high incidence of edema formation (82%) demonstrated spontaneously released histamine and prostaglandin E2 levels higher than those of closely related nonedema-forming dogs (0-20%) and/or control dogs. These edema-forming dogs also showed elevated release of tumor necrosis factor-alpha when cells were cultured with Brugia antigen. Toluidine blue staining of infected lymph node sections revealed that the edema-forming dogs had higher numbers of mast cells than infected lymph nodes of nonedema-forming dogs.
PubMed: 9660448
Affiliations:
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