Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm’s Canal Reporter Rat
Identifieur interne : 009283 ( Ncbi/Checkpoint ); précédent : 009282; suivant : 009284Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm’s Canal Reporter Rat
Auteurs : Eunson Jung [États-Unis] ; Daniel Gardner [États-Unis] ; Dongwon Choi [États-Unis] ; Eunkyung Park [États-Unis] ; Young Jin Seong [États-Unis] ; Sara Yang [États-Unis] ; Jorge Castorena-Gonzalez ; Antoine Louveau ; Zhao Zhou [États-Unis] ; Gene K. Lee [États-Unis] ; David P. Perrault [États-Unis] ; Sunju Lee [États-Unis] ; Maxwell Johnson [États-Unis] ; George Daghlian [États-Unis] ; Maria Lee [États-Unis] ; Yeo Jin Hong [États-Unis] ; Yukinari Kato [Japon] ; Jonathan Kipnis ; Michael J. Davis ; Alex K. Wong [États-Unis] ; Young-Kwon Hong [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
The lymphatic system plays a key role in tissue fluid homeostasis, immune cell trafficking, and fat absorption. We previously reported a bacterial artificial chromosome (BAC)-based lymphatic reporter mouse, where EGFP is expressed under the regulation of the Prox1 promoter. This reporter line has been widely used to conveniently visualize lymphatic vessels and other Prox1-expressing tissues such as Schlemm’s canal. However, mice have a number of experimental limitations due to small body size. By comparison, laboratory rats are larger in size and more closely model the metabolic, physiological, and surgical aspects of humans. Here, we report development of a novel lymphatic reporter rat using the mouse Prox1-EGFP BAC. Despite the species mismatch, the mouse Prox1-EGFP BAC enabled a reliable expression of EGFP in Prox1-expressing cells of the transgenic rats and allowed a convenient visualization of all lymphatic vessels, including those in the central nervous system, and Schlemm’s canal. To demonstrate the utility of this new reporter rat, we studied the contractile properties and valvular functions of mesenteric lymphatics, developed a surgical model for vascularized lymph node transplantation, and confirmed Prox1 expression in venous valves. Together, Prox1-EGFP rat model will contribute to the advancement of lymphatic research as a valuable experimental resource.
Url:
DOI: 10.1038/s41598-017-06031-3
PubMed: 28717161
PubMed Central: 5514086
Affiliations:
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<author><name sortKey="Jin Hong, Yeo" sort="Jin Hong, Yeo" uniqKey="Jin Hong Y" first="Yeo" last="Jin Hong">Yeo Jin Hong</name>
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<author><name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name>
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<author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm’s Canal Reporter Rat</title>
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<author><name sortKey="Gardner, Daniel" sort="Gardner, Daniel" uniqKey="Gardner D" first="Daniel" last="Gardner">Daniel Gardner</name>
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Los Angeles, California USA</nlm:aff>
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<author><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name>
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Los Angeles, California USA</nlm:aff>
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Los Angeles, California USA</nlm:aff>
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</author>
<author><name sortKey="Jin Seong, Young" sort="Jin Seong, Young" uniqKey="Jin Seong Y" first="Young" last="Jin Seong">Young Jin Seong</name>
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Los Angeles, California USA</nlm:aff>
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<author><name sortKey="Yang, Sara" sort="Yang, Sara" uniqKey="Yang S" first="Sara" last="Yang">Sara Yang</name>
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<institution>Department of Biochemistry and Molecular Medicine,</institution>
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Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
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</author>
<author><name sortKey="Castorena Gonzalez, Jorge" sort="Castorena Gonzalez, Jorge" uniqKey="Castorena Gonzalez J" first="Jorge" last="Castorena-Gonzalez">Jorge Castorena-Gonzalez</name>
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<institution>Department of Medical Pharmacology and Physiology,</institution>
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</institution-wrap>
Columbia, Missouri USA</nlm:aff>
<wicri:noCountry code="subfield">Missouri USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Louveau, Antoine" sort="Louveau, Antoine" uniqKey="Louveau A" first="Antoine" last="Louveau">Antoine Louveau</name>
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<institution>Center for Brain Immunology and Glia,</institution>
<institution>Department of Neuroscience, University of Virginia School of Medicine,</institution>
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Charlottesville, Virginia USA</nlm:aff>
<wicri:noCountry code="subfield">Virginia USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhou, Zhao" sort="Zhou, Zhao" uniqKey="Zhou Z" first="Zhao" last="Zhou">Zhao Zhou</name>
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<country>États-Unis</country>
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<author><name sortKey="Lee, Gene K" sort="Lee, Gene K" uniqKey="Lee G" first="Gene K." last="Lee">Gene K. Lee</name>
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<country>États-Unis</country>
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</placeName>
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<author><name sortKey="Perrault, David P" sort="Perrault, David P" uniqKey="Perrault D" first="David P." last="Perrault">David P. Perrault</name>
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Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
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<author><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name>
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Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
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</institution-wrap>
Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
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</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
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<author><name sortKey="Johnson, Maxwell" sort="Johnson, Maxwell" uniqKey="Johnson M" first="Maxwell" last="Johnson">Maxwell Johnson</name>
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Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
</affiliation>
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<institution-id institution-id-type="GRID">grid.42505.36</institution-id>
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<institution>Department of Surgery, Keck School of Medicine, University of Southern California,</institution>
</institution-wrap>
Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id>
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Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
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<author><name sortKey="Lee, Maria" sort="Lee, Maria" uniqKey="Lee M" first="Maria" last="Lee">Maria Lee</name>
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<institution>Department of Surgery, Keck School of Medicine, University of Southern California,</institution>
</institution-wrap>
Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id>
<institution-id institution-id-type="GRID">grid.42505.36</institution-id>
<institution>Department of Biochemistry and Molecular Medicine,</institution>
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Los Angeles, California USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jin Hong, Yeo" sort="Jin Hong, Yeo" uniqKey="Jin Hong Y" first="Yeo" last="Jin Hong">Yeo Jin Hong</name>
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Los Angeles, California USA</nlm:aff>
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</placeName>
<wicri:cityArea>Los Angeles</wicri:cityArea>
</affiliation>
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<author><name sortKey="Kato, Yukinari" sort="Kato, Yukinari" uniqKey="Kato Y" first="Yukinari" last="Kato">Yukinari Kato</name>
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<institution>Department of Regional Innovation,</institution>
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Sendai, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
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<author><name sortKey="Kipnis, Jonathan" sort="Kipnis, Jonathan" uniqKey="Kipnis J" first="Jonathan" last="Kipnis">Jonathan Kipnis</name>
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<institution-id institution-id-type="GRID">grid.27755.32</institution-id>
<institution>Center for Brain Immunology and Glia,</institution>
<institution>Department of Neuroscience, University of Virginia School of Medicine,</institution>
</institution-wrap>
Charlottesville, Virginia USA</nlm:aff>
<wicri:noCountry code="subfield">Virginia USA</wicri:noCountry>
</affiliation>
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<institution-id institution-id-type="GRID">grid.134936.a</institution-id>
<institution>Department of Medical Pharmacology and Physiology,</institution>
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</institution-wrap>
Columbia, Missouri USA</nlm:aff>
<wicri:noCountry code="subfield">Missouri USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name>
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Los Angeles, California USA</nlm:aff>
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<author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
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Los Angeles, California USA</nlm:aff>
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Los Angeles, California USA</nlm:aff>
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</placeName>
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</analytic>
<series><title level="j">Scientific Reports</title>
<idno type="eISSN">2045-2322</idno>
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<front><div type="abstract" xml:lang="en"><p id="Par1">The lymphatic system plays a key role in tissue fluid homeostasis, immune cell trafficking, and fat absorption. We previously reported a bacterial artificial chromosome (BAC)-based lymphatic reporter mouse, where EGFP is expressed under the regulation of the Prox1 promoter. This reporter line has been widely used to conveniently visualize lymphatic vessels and other Prox1-expressing tissues such as Schlemm’s canal. However, mice have a number of experimental limitations due to small body size. By comparison, laboratory rats are larger in size and more closely model the metabolic, physiological, and surgical aspects of humans. Here, we report development of a novel lymphatic reporter rat using the mouse Prox1-EGFP BAC. Despite the species mismatch, the mouse Prox1-EGFP BAC enabled a reliable expression of EGFP in Prox1-expressing cells of the transgenic rats and allowed a convenient visualization of all lymphatic vessels, including those in the central nervous system, and Schlemm’s canal. To demonstrate the utility of this new reporter rat, we studied the contractile properties and valvular functions of mesenteric lymphatics, developed a surgical model for vascularized lymph node transplantation, and confirmed Prox1 expression in venous valves. Together, Prox1-EGFP rat model will contribute to the advancement of lymphatic research as a valuable experimental resource.</p>
</div>
</front>
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</author>
<author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Banerji, S" uniqKey="Banerji S">S Banerji</name>
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</analytic>
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<biblStruct><analytic><author><name sortKey="Srinivasan, Rs" uniqKey="Srinivasan R">RS Srinivasan</name>
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<author><name sortKey="Harvey, N" uniqKey="Harvey N">N Harvey</name>
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<biblStruct><analytic><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name>
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<biblStruct><analytic><author><name sortKey="Pham, Th" uniqKey="Pham T">TH Pham</name>
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<biblStruct><analytic><author><name sortKey="Sabine, A" uniqKey="Sabine A">A Sabine</name>
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<biblStruct><analytic><author><name sortKey="Norrmen, C" uniqKey="Norrmen C">C Norrmen</name>
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<author><name sortKey="Hamilton, Rw" uniqKey="Hamilton R">RW Hamilton</name>
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<biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name>
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</TEI>
<affiliations><list><country><li>Japon</li>
<li>États-Unis</li>
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<tree><noCountry><name sortKey="Castorena Gonzalez, Jorge" sort="Castorena Gonzalez, Jorge" uniqKey="Castorena Gonzalez J" first="Jorge" last="Castorena-Gonzalez">Jorge Castorena-Gonzalez</name>
<name sortKey="Davis, Michael J" sort="Davis, Michael J" uniqKey="Davis M" first="Michael J." last="Davis">Michael J. Davis</name>
<name sortKey="Kipnis, Jonathan" sort="Kipnis, Jonathan" uniqKey="Kipnis J" first="Jonathan" last="Kipnis">Jonathan Kipnis</name>
<name sortKey="Louveau, Antoine" sort="Louveau, Antoine" uniqKey="Louveau A" first="Antoine" last="Louveau">Antoine Louveau</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Jung, Eunson" sort="Jung, Eunson" uniqKey="Jung E" first="Eunson" last="Jung">Eunson Jung</name>
</region>
<name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name>
<name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name>
<name sortKey="Daghlian, George" sort="Daghlian, George" uniqKey="Daghlian G" first="George" last="Daghlian">George Daghlian</name>
<name sortKey="Daghlian, George" sort="Daghlian, George" uniqKey="Daghlian G" first="George" last="Daghlian">George Daghlian</name>
<name sortKey="Gardner, Daniel" sort="Gardner, Daniel" uniqKey="Gardner D" first="Daniel" last="Gardner">Daniel Gardner</name>
<name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
<name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
<name sortKey="Jin Hong, Yeo" sort="Jin Hong, Yeo" uniqKey="Jin Hong Y" first="Yeo" last="Jin Hong">Yeo Jin Hong</name>
<name sortKey="Jin Hong, Yeo" sort="Jin Hong, Yeo" uniqKey="Jin Hong Y" first="Yeo" last="Jin Hong">Yeo Jin Hong</name>
<name sortKey="Jin Seong, Young" sort="Jin Seong, Young" uniqKey="Jin Seong Y" first="Young" last="Jin Seong">Young Jin Seong</name>
<name sortKey="Jin Seong, Young" sort="Jin Seong, Young" uniqKey="Jin Seong Y" first="Young" last="Jin Seong">Young Jin Seong</name>
<name sortKey="Johnson, Maxwell" sort="Johnson, Maxwell" uniqKey="Johnson M" first="Maxwell" last="Johnson">Maxwell Johnson</name>
<name sortKey="Jung, Eunson" sort="Jung, Eunson" uniqKey="Jung E" first="Eunson" last="Jung">Eunson Jung</name>
<name sortKey="Lee, Gene K" sort="Lee, Gene K" uniqKey="Lee G" first="Gene K." last="Lee">Gene K. Lee</name>
<name sortKey="Lee, Maria" sort="Lee, Maria" uniqKey="Lee M" first="Maria" last="Lee">Maria Lee</name>
<name sortKey="Lee, Maria" sort="Lee, Maria" uniqKey="Lee M" first="Maria" last="Lee">Maria Lee</name>
<name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name>
<name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name>
<name sortKey="Park, Eunkyung" sort="Park, Eunkyung" uniqKey="Park E" first="Eunkyung" last="Park">Eunkyung Park</name>
<name sortKey="Park, Eunkyung" sort="Park, Eunkyung" uniqKey="Park E" first="Eunkyung" last="Park">Eunkyung Park</name>
<name sortKey="Perrault, David P" sort="Perrault, David P" uniqKey="Perrault D" first="David P." last="Perrault">David P. Perrault</name>
<name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name>
<name sortKey="Yang, Sara" sort="Yang, Sara" uniqKey="Yang S" first="Sara" last="Yang">Sara Yang</name>
<name sortKey="Yang, Sara" sort="Yang, Sara" uniqKey="Yang S" first="Sara" last="Yang">Sara Yang</name>
<name sortKey="Zhou, Zhao" sort="Zhou, Zhao" uniqKey="Zhou Z" first="Zhao" last="Zhou">Zhao Zhou</name>
</country>
<country name="Japon"><noRegion><name sortKey="Kato, Yukinari" sort="Kato, Yukinari" uniqKey="Kato Y" first="Yukinari" last="Kato">Yukinari Kato</name>
</noRegion>
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</record>
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