[A study of ivermectin in the treatment of lymphatic filariasis due to Wuchereria bancrofti var. pacifica in French Polynesia].
Identifieur interne : 008592 ( Ncbi/Checkpoint ); précédent : 008591; suivant : 008593[A study of ivermectin in the treatment of lymphatic filariasis due to Wuchereria bancrofti var. pacifica in French Polynesia].
Auteurs : J. Roux ; P. Perolat ; J L Cartel ; J P Boutin ; Y. Sechan ; M. Larivière ; M A AzizSource :
- Bulletin de la Societe de pathologie exotique et de ses filiales ; 1989.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Ivermectine.
- traitement médicamenteux : Filariose lymphatique, Filarioses, Porteur sain.
- usage thérapeutique : Ivermectine.
- Adulte, Animaux, Humains, Mâle, Polynésie, Wuchereria.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Ivermectin.
- geographic : Polynesia.
- drug therapy : Carrier State, Elephantiasis, Filarial, Filariasis.
- chemical , therapeutic use : Ivermectin.
- Adult, Animals, Humans, Male, Wuchereria.
Abstract
Forty carriers of 20 or more W. bancrofti var. pacifica per ml were blind administered ivermectin at 50, 100, 150 or 200 mcg/kg doses. The rate of successful treatment was 100% with the 4 dosages. The percentage cure rate and the decrease percentage in the microfilarial count were significantly higher in persons treated with 100, 150 and 200 mcg/kg than in persons treated with 50 mcg/kg. Frequency and intensity of side-reactions were similar to those observed during treatment with DEC; they were more frequent and severe in persons with greatest microfilaremia but did not depend on the dosage. Ivermectin in 100 mcg/kg single-dose, administered once a year, is the best candidate to replace DEC in mass treatments.
PubMed: 2743520
Affiliations:
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pubmed:2743520Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[A study of ivermectin in the treatment of lymphatic filariasis due to Wuchereria bancrofti var. pacifica in French Polynesia].</title>
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<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Filariasis (drug therapy)</term>
<term>Humans</term>
<term>Ivermectin (adverse effects)</term>
<term>Ivermectin (therapeutic use)</term>
<term>Male</term>
<term>Polynesia</term>
<term>Wuchereria</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Animaux</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Filarioses (traitement médicamenteux)</term>
<term>Humains</term>
<term>Ivermectine (effets indésirables)</term>
<term>Ivermectine (usage thérapeutique)</term>
<term>Mâle</term>
<term>Polynésie</term>
<term>Porteur sain (traitement médicamenteux)</term>
<term>Wuchereria</term>
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<term>Elephantiasis, Filarial</term>
<term>Filariasis</term>
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<front><div type="abstract" xml:lang="en">Forty carriers of 20 or more W. bancrofti var. pacifica per ml were blind administered ivermectin at 50, 100, 150 or 200 mcg/kg doses. The rate of successful treatment was 100% with the 4 dosages. The percentage cure rate and the decrease percentage in the microfilarial count were significantly higher in persons treated with 100, 150 and 200 mcg/kg than in persons treated with 50 mcg/kg. Frequency and intensity of side-reactions were similar to those observed during treatment with DEC; they were more frequent and severe in persons with greatest microfilaremia but did not depend on the dosage. Ivermectin in 100 mcg/kg single-dose, administered once a year, is the best candidate to replace DEC in mass treatments.</div>
</front>
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<name sortKey="Cartel, J L" sort="Cartel, J L" uniqKey="Cartel J" first="J L" last="Cartel">J L Cartel</name>
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<name sortKey="Perolat, P" sort="Perolat, P" uniqKey="Perolat P" first="P" last="Perolat">P. Perolat</name>
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