Inappropriateness of the association of diphenhydramine with diethylcarbamazine for the treatment of lymphatic filariasis.
Identifieur interne : 007A06 ( Ncbi/Checkpoint ); précédent : 007A05; suivant : 007A07Inappropriateness of the association of diphenhydramine with diethylcarbamazine for the treatment of lymphatic filariasis.
Auteurs : G. Dreyer [Brésil] ; L. De AndradeSource :
- The Journal of tropical medicine and hygiene [ 0022-5304 ] ; 1989.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Association médicamenteuse, Attribution aléatoire, Diphénhydramine (effets indésirables), Diphénhydramine (usage thérapeutique), Diéthylcarbamazine (effets indésirables), Diéthylcarbamazine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Filariose lymphatique (traitement médicamenteux), Filarioses (traitement médicamenteux), Humains, Nourrisson, Phases du sommeil (), Wuchereria bancrofti.
- MESH :
- effets indésirables : Diphénhydramine, Diéthylcarbamazine.
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Diphénhydramine, Diéthylcarbamazine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Association médicamenteuse, Attribution aléatoire, Enfant, Enfant d'âge préscolaire, Humains, Nourrisson, Phases du sommeil, Wuchereria bancrofti.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Child, Child, Preschool, Diethylcarbamazine (adverse effects), Diethylcarbamazine (therapeutic use), Diphenhydramine (adverse effects), Diphenhydramine (therapeutic use), Drug Combinations, Elephantiasis, Filarial (drug therapy), Filariasis (drug therapy), Humans, Infant, Middle Aged, Random Allocation, Sleep Stages (drug effects), Wuchereria bancrofti.
- MESH :
- chemical , adverse effects : Diethylcarbamazine, Diphenhydramine.
- chemical , therapeutic use : Diethylcarbamazine, Diphenhydramine.
- drug effects : Sleep Stages.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- Adolescent, Adult, Animals, Child, Child, Preschool, Drug Combinations, Humans, Infant, Middle Aged, Random Allocation, Wuchereria bancrofti.
Abstract
The efficacy of diphenhydramine, an antihistaminic, in preventing adverse reactions to diethylcarbamazine (DEC) in patients infected with Wuchereria bancrofti, was assessed by treating 50 patients with both drugs and 57 with DEC alone. It was found to be ineffective, and to cause drowsiness in all those unaffected by adverse reactions. The authors conclude that the combined use of both drugs for the treatment of Bancroftian filariasis, which is the usual practice in Brazil, should be avoided.
PubMed: 2645415
Affiliations:
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pubmed:2645415Le document en format XML
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De Andrade</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2645415</idno><idno type="pmid">2645415</idno><idno type="wicri:Area/PubMed/Corpus">006034</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006034</idno><idno type="wicri:Area/PubMed/Curation">006034</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">006034</idno><idno type="wicri:Area/PubMed/Checkpoint">006034</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">006034</idno><idno type="wicri:Area/Ncbi/Merge">007A06</idno><idno type="wicri:Area/Ncbi/Curation">007A06</idno><idno type="wicri:Area/Ncbi/Checkpoint">007A06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inappropriateness of the association of diphenhydramine with diethylcarbamazine for the treatment of lymphatic filariasis.</title><author><name sortKey="Dreyer, G" sort="Dreyer, G" uniqKey="Dreyer G" first="G" last="Dreyer">G. Dreyer</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Pesquisas Aggeu magalhaes, Departamento de Parasitologia, Recife, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Pesquisas Aggeu magalhaes, Departamento de Parasitologia, Recife</wicri:regionArea><wicri:noRegion>Recife</wicri:noRegion></affiliation></author><author><name sortKey="De Andrade, L" sort="De Andrade, L" uniqKey="De Andrade L" first="L" last="De Andrade">L. De Andrade</name></author></analytic><series><title level="j">The Journal of tropical medicine and hygiene</title><idno type="ISSN">0022-5304</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Diethylcarbamazine (adverse effects)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Diphenhydramine (adverse effects)</term><term>Diphenhydramine (therapeutic use)</term><term>Drug Combinations</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Filariasis (drug therapy)</term><term>Humans</term><term>Infant</term><term>Middle Aged</term><term>Random Allocation</term><term>Sleep Stages (drug effects)</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Association médicamenteuse</term><term>Attribution aléatoire</term><term>Diphénhydramine (effets indésirables)</term><term>Diphénhydramine (usage thérapeutique)</term><term>Diéthylcarbamazine (effets indésirables)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (traitement médicamenteux)</term><term>Humains</term><term>Nourrisson</term><term>Phases du sommeil ()</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Diethylcarbamazine</term><term>Diphenhydramine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Diphenhydramine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Sleep Stages</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Diphénhydramine</term><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diphénhydramine</term><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Drug Combinations</term><term>Humans</term><term>Infant</term><term>Middle Aged</term><term>Random Allocation</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Association médicamenteuse</term><term>Attribution aléatoire</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Nourrisson</term><term>Phases du sommeil</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The efficacy of diphenhydramine, an antihistaminic, in preventing adverse reactions to diethylcarbamazine (DEC) in patients infected with Wuchereria bancrofti, was assessed by treating 50 patients with both drugs and 57 with DEC alone. It was found to be ineffective, and to cause drowsiness in all those unaffected by adverse reactions. The authors conclude that the combined use of both drugs for the treatment of Bancroftian filariasis, which is the usual practice in Brazil, should be avoided.</div></front></TEI><affiliations><list><country><li>Brésil</li></country></list><tree><noCountry><name sortKey="De Andrade, L" sort="De Andrade, L" uniqKey="De Andrade L" first="L" last="De Andrade">L. De Andrade</name></noCountry><country name="Brésil"><noRegion><name sortKey="Dreyer, G" sort="Dreyer, G" uniqKey="Dreyer G" first="G" last="Dreyer">G. Dreyer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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