Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression
Identifieur interne : 007651 ( Ncbi/Checkpoint ); précédent : 007650; suivant : 007652Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression
Auteurs : Annika Schuermann [Allemagne] ; Christian S. M. Helker [Allemagne] ; Wiebke Herzog [Allemagne]Source :
- Angiogenesis [ 0969-6970 ] ; 2015.
Abstract
Analysis of developmental angiogenesis can help to identify regulatory networks, which also contribute to disease-related vascular growth. Vascular endothelial growth factors (Vegf) drive angiogenic processes such as sprouting, endothelial cell (EC) migration and proliferation. However, how Vegf expression is regulated during development is not well understood. By analyzing developmental zebrafish angiogenesis, we have identified Metallothionein 2 (Mt2) as a novel regulator of
The online version of this article (doi:10.1007/s10456-015-9473-6) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s10456-015-9473-6
PubMed: 26198291
PubMed Central: 4596909
Affiliations:
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M." last="Helker">Christian S. M. Helker</name><affiliation wicri:level="1"><nlm:aff id="Aff1">University of Muenster, Muenster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institute for Heart and Lung Research, Bad Nauheim</wicri:regionArea><wicri:noRegion>Bad Nauheim</wicri:noRegion><wicri:noRegion>Bad Nauheim</wicri:noRegion><wicri:noRegion>Bad Nauheim</wicri:noRegion></affiliation></author><author><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><affiliation wicri:level="1"><nlm:aff id="Aff1">University of Muenster, Muenster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Muenster, Muenster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Max-Planck-Institute for Molecular Biomedicine, Muenster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institute for Molecular Biomedicine, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author></analytic><series><title level="j">Angiogenesis</title><idno type="ISSN">0969-6970</idno><idno type="eISSN">1573-7209</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Analysis of developmental angiogenesis can help to identify regulatory networks, which also contribute to disease-related vascular growth. Vascular endothelial growth factors (Vegf) drive angiogenic processes such as sprouting, endothelial cell (EC) migration and proliferation. However, how Vegf expression is regulated during development is not well understood. By analyzing developmental zebrafish angiogenesis, we have identified Metallothionein 2 (Mt2) as a novel regulator of <italic>vegfc</italic> expression. While Metallothioneins (Mts) have been extensively analyzed for their capability of regulating homeostasis and metal detoxification, we demonstrate that Mt2 is required for EC migration, proliferation and angiogenic sprouting upstream of <italic>vegfc</italic> expression. We further demonstrate that another Mt family member cannot compensate Mt2 deficiency and therefore postulate that Mt2 regulates angiogenesis independent of its canonical Mt function. Our data not only reveal a non-canonical function of Mt2 in angiogenesis, but also propose Mt2 as a novel regulator of <italic>vegfc</italic> expression.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s10456-015-9473-6) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bussmann, J" uniqKey="Bussmann J">J Bussmann</name></author><author><name sortKey="Lawson, N" uniqKey="Lawson N">N Lawson</name></author><author><name sortKey="Zon, L" uniqKey="Zon L">L Zon</name></author><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lohela, M" uniqKey="Lohela M">M Lohela</name></author><author><name sortKey="Bry, M" uniqKey="Bry M">M Bry</name></author><author><name sortKey="Tammela, T" 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Lawson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Schuermann, Annika" sort="Schuermann, Annika" uniqKey="Schuermann A" first="Annika" last="Schuermann">Annika Schuermann</name></noRegion><name sortKey="Helker, Christian S M" sort="Helker, Christian S M" uniqKey="Helker C" first="Christian S. M." last="Helker">Christian S. M. Helker</name><name sortKey="Helker, Christian S M" sort="Helker, Christian S M" uniqKey="Helker C" first="Christian S. M." last="Helker">Christian S. M. Helker</name><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><name sortKey="Schuermann, Annika" sort="Schuermann, Annika" uniqKey="Schuermann A" first="Annika" last="Schuermann">Annika Schuermann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression
}}
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