Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress.
Identifieur interne : 007454 ( Ncbi/Checkpoint ); précédent : 007453; suivant : 007455Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress.
Auteurs : J N Benoit ; D C Zawieja ; A H Goodman ; H J GrangerSource :
- The American journal of physiology [ 0002-9513 ] ; 1989.
Descripteurs français
- KwdFr :
- Animaux, Contraction musculaire, Diastole, Facteurs temps, Lignées consanguines de rats, Lymphe (physiologie), Lymphoedème (physiopathologie), Modèles biologiques, Muscles lisses (physiologie), Muscles lisses (physiopathologie), Mâle, Pression, Rats, Systole, Système lymphatique (physiologie), Système lymphatique (physiopathologie).
- MESH :
- physiologie : Lymphe, Muscles lisses, Système lymphatique.
- physiopathologie : Lymphoedème, Muscles lisses, Système lymphatique.
- Animaux, Contraction musculaire, Diastole, Facteurs temps, Lignées consanguines de rats, Modèles biologiques, Mâle, Pression, Rats, Systole.
English descriptors
- KwdEn :
- Animals, Diastole, Lymph (physiology), Lymphatic System (physiology), Lymphatic System (physiopathology), Lymphedema (physiopathology), Male, Models, Biological, Muscle Contraction, Muscle, Smooth (physiology), Muscle, Smooth (physiopathology), Pressure, Rats, Rats, Inbred Strains, Systole, Time Factors.
- MESH :
- physiology : Lymph, Lymphatic System, Muscle, Smooth.
- physiopathology : Lymphatic System, Lymphedema, Muscle, Smooth.
- Animals, Diastole, Male, Models, Biological, Muscle Contraction, Pressure, Rats, Rats, Inbred Strains, Systole, Time Factors.
Abstract
The contractile properties of the mesenteric collecting lymphatics of the rat were analyzed under control conditions and during periods of enhanced lymph formation using in vivo microscopic techniques. Pressure and diameter were simultaneously monitored in microscopic collecting lymphatics, and lymphatic pump function was analyzed in accordance with basic principles of cardiac mechanics. The lymphatic contractile cycle was divided into two phases of systole and four phases of diastole. Under control conditions, lymphatics contracted with a frequency of 6.4 +/- 0.61 beats/min and ejected approximately 67% of their end-diastolic volume. Ten minutes after the rate of lymph formation was elevated by plasma dilution, end-diastolic diameter, contraction frequency, ejection fraction, and stroke volume increased. Pressure in the lymphatic network became less pulsatile in high lymph flow states. Contractility, an index of inotropic changes in lymphatic pump, was unaltered when lymph flow was increased by plasma dilution. Furthermore, the maximal shortening velocity of lymphatic smooth muscle did not change during periods of enhanced lymph flow. Thus it appears that passive increases in the rate of lymph formation exert few, if any, inotropic effects on the lymphatic pump. The augmented stroke volume and contraction frequency appear to result mainly from intrinsic stretch-dependent mechanisms set in motion by elevated preload. These data represent the first comprehensive characterization of both the flow-generating and muscle characteristics of intact collecting lymphatics and provide a basis for future studies on the physiological regulation of lymphatic contraction.
PubMed: 2603989
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 005F09
- to stream PubMed, to step Curation: 005F09
- to stream PubMed, to step Checkpoint: 005F09
- to stream Ncbi, to step Merge: 007454
- to stream Ncbi, to step Curation: 007454
Links to Exploration step
pubmed:2603989Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress.</title><author><name sortKey="Benoit, J N" sort="Benoit, J N" uniqKey="Benoit J" first="J N" last="Benoit">J N Benoit</name><affiliation><nlm:affiliation>Microcirculation Research Institute, College of Medicine, Texas A & M University, College Station 77843.</nlm:affiliation><wicri:noCountry code="subField">College Station 77843</wicri:noCountry></affiliation></author><author><name sortKey="Zawieja, D C" sort="Zawieja, D C" uniqKey="Zawieja D" first="D C" last="Zawieja">D C Zawieja</name></author><author><name sortKey="Goodman, A H" sort="Goodman, A H" uniqKey="Goodman A" first="A H" last="Goodman">A H Goodman</name></author><author><name sortKey="Granger, H J" sort="Granger, H J" uniqKey="Granger H" first="H J" last="Granger">H J Granger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2603989</idno><idno type="pmid">2603989</idno><idno type="wicri:Area/PubMed/Corpus">005F09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005F09</idno><idno type="wicri:Area/PubMed/Curation">005F09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005F09</idno><idno type="wicri:Area/PubMed/Checkpoint">005F09</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005F09</idno><idno type="wicri:Area/Ncbi/Merge">007454</idno><idno type="wicri:Area/Ncbi/Curation">007454</idno><idno type="wicri:Area/Ncbi/Checkpoint">007454</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress.</title><author><name sortKey="Benoit, J N" sort="Benoit, J N" uniqKey="Benoit J" first="J N" last="Benoit">J N Benoit</name><affiliation><nlm:affiliation>Microcirculation Research Institute, College of Medicine, Texas A & M University, College Station 77843.</nlm:affiliation><wicri:noCountry code="subField">College Station 77843</wicri:noCountry></affiliation></author><author><name sortKey="Zawieja, D C" sort="Zawieja, D C" uniqKey="Zawieja D" first="D C" last="Zawieja">D C Zawieja</name></author><author><name sortKey="Goodman, A H" sort="Goodman, A H" uniqKey="Goodman A" first="A H" last="Goodman">A H Goodman</name></author><author><name sortKey="Granger, H J" sort="Granger, H J" uniqKey="Granger H" first="H J" last="Granger">H J Granger</name></author></analytic><series><title level="j">The American journal of physiology</title><idno type="ISSN">0002-9513</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Diastole</term><term>Lymph (physiology)</term><term>Lymphatic System (physiology)</term><term>Lymphatic System (physiopathology)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Models, Biological</term><term>Muscle Contraction</term><term>Muscle, Smooth (physiology)</term><term>Muscle, Smooth (physiopathology)</term><term>Pressure</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Systole</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Contraction musculaire</term><term>Diastole</term><term>Facteurs temps</term><term>Lignées consanguines de rats</term><term>Lymphe (physiologie)</term><term>Lymphoedème (physiopathologie)</term><term>Modèles biologiques</term><term>Muscles lisses (physiologie)</term><term>Muscles lisses (physiopathologie)</term><term>Mâle</term><term>Pression</term><term>Rats</term><term>Systole</term><term>Système lymphatique (physiologie)</term><term>Système lymphatique (physiopathologie)</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term><term>Muscles lisses</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term><term>Lymphatic System</term><term>Muscle, Smooth</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Muscles lisses</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic System</term><term>Lymphedema</term><term>Muscle, Smooth</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diastole</term><term>Male</term><term>Models, Biological</term><term>Muscle Contraction</term><term>Pressure</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Systole</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Contraction musculaire</term><term>Diastole</term><term>Facteurs temps</term><term>Lignées consanguines de rats</term><term>Modèles biologiques</term><term>Mâle</term><term>Pression</term><term>Rats</term><term>Systole</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The contractile properties of the mesenteric collecting lymphatics of the rat were analyzed under control conditions and during periods of enhanced lymph formation using in vivo microscopic techniques. Pressure and diameter were simultaneously monitored in microscopic collecting lymphatics, and lymphatic pump function was analyzed in accordance with basic principles of cardiac mechanics. The lymphatic contractile cycle was divided into two phases of systole and four phases of diastole. Under control conditions, lymphatics contracted with a frequency of 6.4 +/- 0.61 beats/min and ejected approximately 67% of their end-diastolic volume. Ten minutes after the rate of lymph formation was elevated by plasma dilution, end-diastolic diameter, contraction frequency, ejection fraction, and stroke volume increased. Pressure in the lymphatic network became less pulsatile in high lymph flow states. Contractility, an index of inotropic changes in lymphatic pump, was unaltered when lymph flow was increased by plasma dilution. Furthermore, the maximal shortening velocity of lymphatic smooth muscle did not change during periods of enhanced lymph flow. Thus it appears that passive increases in the rate of lymph formation exert few, if any, inotropic effects on the lymphatic pump. The augmented stroke volume and contraction frequency appear to result mainly from intrinsic stretch-dependent mechanisms set in motion by elevated preload. These data represent the first comprehensive characterization of both the flow-generating and muscle characteristics of intact collecting lymphatics and provide a basis for future studies on the physiological regulation of lymphatic contraction.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Benoit, J N" sort="Benoit, J N" uniqKey="Benoit J" first="J N" last="Benoit">J N Benoit</name><name sortKey="Goodman, A H" sort="Goodman, A H" uniqKey="Goodman A" first="A H" last="Goodman">A H Goodman</name><name sortKey="Granger, H J" sort="Granger, H J" uniqKey="Granger H" first="H J" last="Granger">H J Granger</name><name sortKey="Zawieja, D C" sort="Zawieja, D C" uniqKey="Zawieja D" first="D C" last="Zawieja">D C Zawieja</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007454 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 007454 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:2603989
|texte= Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:2603989" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |