Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations
Identifieur interne : 007273 ( Ncbi/Checkpoint ); précédent : 007272; suivant : 007274Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations
Auteurs : Özgün Babur [États-Unis] ; Mithat Gönen [États-Unis] ; Bülent Arman Aksoy [États-Unis] ; Nikolaus Schultz [États-Unis] ; Giovanni Ciriello [États-Unis] ; Chris Sander [États-Unis] ; Emek Demir [États-Unis]Source :
- Genome Biology [ 1465-6906 ] ; 2015.
Abstract
We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.
The online version of this article (doi:10.1186/s13059-015-0612-6) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13059-015-0612-6
PubMed: 25887147
PubMed Central: 4381444
Affiliations:
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uniqKey="Demir E" first="Emek" last="Demir">Emek Demir</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 460, New York, 10065 USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 460, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Genome Biology</title><idno type="ISSN">1465-6906</idno><idno type="eISSN">1465-6914</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13059-015-0612-6) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bozic, I" uniqKey="Bozic I">I Bozic</name></author><author><name sortKey="Antal, T" uniqKey="Antal T">T Antal</name></author><author><name sortKey="Ohtsuki, H" uniqKey="Ohtsuki H">H Ohtsuki</name></author><author><name sortKey="Carter, H" uniqKey="Carter H">H Carter</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D Kim</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xing, M" uniqKey="Xing M">M Xing</name></author><author><name sortKey="Cohen, Y" uniqKey="Cohen Y">Y Cohen</name></author><author><name sortKey="Mambo, E" uniqKey="Mambo E">E Mambo</name></author><author><name sortKey="Tallini, G" uniqKey="Tallini G">G Tallini</name></author><author><name sortKey="Udelsman, R" uniqKey="Udelsman R">R Udelsman</name></author><author><name sortKey="Ladenson, Pw" uniqKey="Ladenson P">PW Ladenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Hou, P" uniqKey="Hou P">P Hou</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Ji, M" uniqKey="Ji M">M Ji</name></author><author><name sortKey="Zhao, S" uniqKey="Zhao S">S Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carbuccia, N" uniqKey="Carbuccia N">N Carbuccia</name></author><author><name sortKey="Trouplin, V" uniqKey="Trouplin V">V Trouplin</name></author><author><name sortKey="Gelsi Boyer, V" uniqKey="Gelsi Boyer V">V Gelsi-Boyer</name></author><author><name sortKey="Murati, A" uniqKey="Murati A">A Murati</name></author><author><name sortKey="Rocquain, J" uniqKey="Rocquain J">J Rocquain</name></author><author><name sortKey="Adelaide, J" uniqKey="Adelaide J">J Adélaïde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeang, Ch" uniqKey="Yeang C">CH Yeang</name></author><author><name sortKey="Mccormick, F" uniqKey="Mccormick F">F McCormick</name></author><author><name sortKey="Levine, A" uniqKey="Levine A">A Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Ca" uniqKey="Miller C">CA Miller</name></author><author><name sortKey="Settle, Sh" uniqKey="Settle S">SH Settle</name></author><author><name sortKey="Sulman, Ep" uniqKey="Sulman E">EP Sulman</name></author><author><name sortKey="Aldape, Kd" uniqKey="Aldape K">KD Aldape</name></author><author><name sortKey="Milosavljevic, A" uniqKey="Milosavljevic A">A Milosavljevic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ciriello, G" uniqKey="Ciriello G">G Ciriello</name></author><author><name sortKey="Cerami, E" uniqKey="Cerami E">E Cerami</name></author><author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name></author><author><name sortKey="Schultz, N" uniqKey="Schultz N">N Schultz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vandin, F" uniqKey="Vandin F">F Vandin</name></author><author><name sortKey="Upfal, E" uniqKey="Upfal E">E Upfal</name></author><author><name sortKey="Raphael, Bj" uniqKey="Raphael B">BJ Raphael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wu, Ly" uniqKey="Wu L">LY Wu</name></author><author><name sortKey="Zhang, Xs" uniqKey="Zhang X">XS Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leiserson, Md" uniqKey="Leiserson M">MD Leiserson</name></author><author><name sortKey="Blokh, D" uniqKey="Blokh D">D Blokh</name></author><author><name sortKey="Sharan, R" uniqKey="Sharan R">R Sharan</name></author><author><name sortKey="Raphael, Bj" uniqKey="Raphael B">BJ Raphael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szczurek, E" uniqKey="Szczurek E">E Szczurek</name></author><author><name sortKey="Beerenwinkel, N" uniqKey="Beerenwinkel N">N Beerenwinkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradley, Jr" uniqKey="Bradley J">JR Bradley</name></author><author><name sortKey="Farnsworth, Dl" uniqKey="Farnsworth D">DL Farnsworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cerami, E" uniqKey="Cerami E">E Cerami</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Dogrusoz, U" uniqKey="Dogrusoz U">U Dogrusoz</name></author><author><name sortKey="Gross, Be" uniqKey="Gross B">BE Gross</name></author><author><name sortKey="Sumer, So" uniqKey="Sumer S">SO Sumer</name></author><author><name sortKey="Aksoy, Ba" uniqKey="Aksoy B">BA Aksoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cerami, Eg" uniqKey="Cerami E">EG Cerami</name></author><author><name sortKey="Gross, Be" uniqKey="Gross B">BE Gross</name></author><author><name sortKey="Demir, E" uniqKey="Demir E">E Demir</name></author><author><name sortKey="Rodchenkov, I" uniqKey="Rodchenkov I">I Rodchenkov</name></author><author><name sortKey="Babur, O" uniqKey="Babur O">Ö Babur</name></author><author><name sortKey="Anwar, N" uniqKey="Anwar N">N Anwar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paz, A" uniqKey="Paz A">A Paz</name></author><author><name sortKey="Brownstein, Z" uniqKey="Brownstein Z">Z Brownstein</name></author><author><name sortKey="Ber, Y" uniqKey="Ber Y">Y Ber</name></author><author><name sortKey="Bialik, S" uniqKey="Bialik S">S Bialik</name></author><author><name sortKey="David, E" uniqKey="David E">E David</name></author><author><name sortKey="Sagir, D" uniqKey="Sagir D">D Sagir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fazekas, D" uniqKey="Fazekas D">D Fazekas</name></author><author><name sortKey="Koltai, M" uniqKey="Koltai M">M Koltai</name></author><author><name sortKey="Turei, D" uniqKey="Turei D">D Türei</name></author><author><name sortKey="M Dos, D" uniqKey="M Dos D">D Módos</name></author><author><name sortKey="Palfy, M" uniqKey="Palfy M">M Pálfy</name></author><author><name sortKey="Dul, Z" uniqKey="Dul Z">Z Dúl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babur, O" uniqKey="Babur O">Ö Babur</name></author><author><name sortKey="Aksoy, Ba" uniqKey="Aksoy B">BA Aksoy</name></author><author><name sortKey="Rodchenkov, I" uniqKey="Rodchenkov I">I Rodchenkov</name></author><author><name sortKey="Sumer, So" uniqKey="Sumer S">SO Sümer</name></author><author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name></author><author><name sortKey="Demir, E" uniqKey="Demir E">E Demir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mclendon, R" uniqKey="Mclendon R">R McLendon</name></author><author><name sortKey="Friedman, A" uniqKey="Friedman A">A Friedman</name></author><author><name sortKey="Bigner, D" uniqKey="Bigner D">D Bigner</name></author><author><name sortKey="Van Meir, Eg" uniqKey="Van Meir E">EG Van Meir</name></author><author><name sortKey="Brat, Dj" uniqKey="Brat D">DJ Brat</name></author><author><name sortKey="Mastrogianakis, Gm" uniqKey="Mastrogianakis G">GM Mastrogianakis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lawrence, Ms" uniqKey="Lawrence M">MS Lawrence</name></author><author><name sortKey="Stojanov, P" uniqKey="Stojanov P">P Stojanov</name></author><author><name sortKey="Polak, P" uniqKey="Polak P">P Polak</name></author><author><name sortKey="Kryukov, Gv" uniqKey="Kryukov G">GV Kryukov</name></author><author><name sortKey="Cibulskis, K" uniqKey="Cibulskis K">K Cibulskis</name></author><author><name sortKey="Sivachenko, A" uniqKey="Sivachenko A">A Sivachenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mermel, Ch" uniqKey="Mermel C">CH Mermel</name></author><author><name sortKey="Schumacher, Se" uniqKey="Schumacher S">SE Schumacher</name></author><author><name sortKey="Hill, B" uniqKey="Hill B">B Hill</name></author><author><name sortKey="Meyerson, Ml" uniqKey="Meyerson M">ML Meyerson</name></author><author><name sortKey="Beroukhim, R" uniqKey="Beroukhim R">R Beroukhim</name></author><author><name sortKey="Getz, G" uniqKey="Getz G">G Getz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ford Speelman, Dl" uniqKey="Ford Speelman D">DL Ford-Speelman</name></author><author><name sortKey="Roche, Ja" uniqKey="Roche J">JA Roche</name></author><author><name sortKey="Bowman, Al" uniqKey="Bowman A">AL Bowman</name></author><author><name sortKey="Bloch, Rj" uniqKey="Bloch R">RJ Bloch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossman, Kl" uniqKey="Rossman K">KL Rossman</name></author><author><name sortKey="Der, Cj" uniqKey="Der C">CJ Der</name></author><author><name sortKey="Sondek, J" uniqKey="Sondek J">J Sondek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dinkel, H" uniqKey="Dinkel H">H Dinkel</name></author><author><name sortKey="Michael, S" uniqKey="Michael S">S Michael</name></author><author><name sortKey="Weatheritt, Rj" uniqKey="Weatheritt R">RJ Weatheritt</name></author><author><name sortKey="Davey, Ne" uniqKey="Davey N">NE Davey</name></author><author><name sortKey="Van Roey, K" uniqKey="Van Roey K">K Van Roey</name></author><author><name sortKey="Altenberg, B" uniqKey="Altenberg B">B Altenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiao, N" uniqKey="Qiao N">N Qiao</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Naveed, H" uniqKey="Naveed H">H Naveed</name></author><author><name sortKey="Green, Cd" uniqKey="Green C">CD Green</name></author><author><name sortKey="Han, J Dj" uniqKey="Han J">J-DJ Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ard, Pg" uniqKey="Ard P">PG Ard</name></author><author><name sortKey="Chatterjee, C" uniqKey="Chatterjee C">C Chatterjee</name></author><author><name sortKey="Kunjibettu, S" uniqKey="Kunjibettu S">S Kunjibettu</name></author><author><name sortKey="Adside, Lr" uniqKey="Adside L">LR Adside</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Mcmahon, Sb" uniqKey="Mcmahon S">SB McMahon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ye, K" uniqKey="Ye K">K Ye</name></author><author><name sortKey="Hurt, Kj" uniqKey="Hurt K">KJ Hurt</name></author><author><name sortKey="Wu, Fy" uniqKey="Wu F">FY Wu</name></author><author><name sortKey="Fang, M" uniqKey="Fang M">M Fang</name></author><author><name sortKey="Luo, Hr" uniqKey="Luo H">HR Luo</name></author><author><name sortKey="Hong, Jj" uniqKey="Hong 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uniqKey="Molyneux G">G Molyneux</name></author><author><name sortKey="Periyasamy, M" uniqKey="Periyasamy M">M Periyasamy</name></author><author><name sortKey="Giamas, G" uniqKey="Giamas G">G Giamas</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weston, Ca" uniqKey="Weston C">CA Weston</name></author><author><name sortKey="Teressa, G" uniqKey="Teressa G">G Teressa</name></author><author><name sortKey="Weeks, Bs" uniqKey="Weeks B">BS Weeks</name></author><author><name sortKey="Prives, J" uniqKey="Prives J">J Prives</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berger, A" uniqKey="Berger A">A Berger</name></author><author><name sortKey="Imielinski, M" uniqKey="Imielinski M">M Imielinski</name></author><author><name sortKey="Duke, F" uniqKey="Duke F">F Duke</name></author><author><name sortKey="Wala, J" uniqKey="Wala J">J Wala</name></author><author><name sortKey="Kaplan, N" uniqKey="Kaplan N">N Kaplan</name></author><author><name sortKey="Shi, G" uniqKey="Shi G">G Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdul, M" uniqKey="Abdul M">M Abdul</name></author><author><name sortKey="Ramlal, S" uniqKey="Ramlal S">S Ramlal</name></author><author><name sortKey="Hoosein, N" uniqKey="Hoosein N">N Hoosein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baek, Hj" uniqKey="Baek H">HJ Baek</name></author><author><name sortKey="Pishvaian, Mj" uniqKey="Pishvaian M">MJ Pishvaian</name></author><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name></author><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Zouhairi, Me" uniqKey="Zouhairi M">ME 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Çakır</name></author><author><name sortKey="Aksoy, Ba" uniqKey="Aksoy B">BA Aksoy</name></author><author><name sortKey="Schultz, N" uniqKey="Schultz N">N Schultz</name></author><author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babur, O" uniqKey="Babur O">O Babur</name></author><author><name sortKey="Dogrusoz, U" uniqKey="Dogrusoz U">U Dogrusoz</name></author><author><name sortKey="Demir, E" uniqKey="Demir E">E Demir</name></author><author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Babur, Ozgun" sort="Babur, Ozgun" uniqKey="Babur O" first="Özgün" last="Babur">Özgün Babur</name></region><name sortKey="Aksoy, Bulent Arman" sort="Aksoy, Bulent Arman" uniqKey="Aksoy B" first="Bülent Arman" last="Aksoy">Bülent Arman Aksoy</name><name sortKey="Aksoy, Bulent Arman" sort="Aksoy, Bulent Arman" uniqKey="Aksoy B" first="Bülent Arman" last="Aksoy">Bülent Arman Aksoy</name><name sortKey="Ciriello, Giovanni" sort="Ciriello, Giovanni" uniqKey="Ciriello G" first="Giovanni" last="Ciriello">Giovanni Ciriello</name><name sortKey="Demir, Emek" sort="Demir, Emek" uniqKey="Demir E" first="Emek" last="Demir">Emek Demir</name><name sortKey="Gonen, Mithat" sort="Gonen, Mithat" uniqKey="Gonen M" first="Mithat" last="Gönen">Mithat Gönen</name><name sortKey="Sander, Chris" sort="Sander, Chris" uniqKey="Sander C" first="Chris" last="Sander">Chris Sander</name><name sortKey="Schultz, Nikolaus" sort="Schultz, Nikolaus" uniqKey="Schultz N" first="Nikolaus" last="Schultz">Nikolaus Schultz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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