Composite Hemangioendothelioma of the Submandibular Region
Identifieur interne : 007016 ( Ncbi/Checkpoint ); précédent : 007015; suivant : 007017Composite Hemangioendothelioma of the Submandibular Region
Auteurs : Sarah Lam Shang Leen ; Peter M. Clarke [Royaume-Uni] ; John Chapman [Royaume-Uni] ; Cyril Fisher [Royaume-Uni] ; Khin Thway [Royaume-Uni]Source :
- Head and Neck Pathology [ 1936-055X ] ; 2015.
Abstract
Composite hemangioendothelioma (HE) is a rare vascular neoplasm of intermediate malignant potential that predominantly occurs within the dermis or subcutis of the extremities, and occurs in a wide age range. It is locally aggressive with a high rate of local recurrence, and more rarely regional lymph node or distant metastasis. Histologically, it is composed of a complex admixture of benign, intermediate and malignant vascular components. Although composite HE may contain angiosarcoma-like areas, its prognosis is better than that of pure angiosarcoma. We describe a case of composite HE presenting as a submandibular mass in a 43 year-old male, which included areas of prominent ‘high grade’ epithelioid angiosarcoma. This adds to the range of anatomic sites of these neoplasms, highlights the importance of recognition of the head and neck as a potential site, and emphasizes the importance of accurate diagnosis for correct management (including of long term follow up) and prognostication.
Url:
DOI: 10.1007/s12105-015-0612-6
PubMed: 25666464
PubMed Central: 4651927
Affiliations:
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Clarke</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chapman, John" sort="Chapman, John" uniqKey="Chapman J" first="John" last="Chapman">John Chapman</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Histopathology, Ipswich Hospital, Ipswich, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Ipswich Hospital, Ipswich</wicri:regionArea><wicri:noRegion>Ipswich</wicri:noRegion></affiliation></author><author><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name><affiliation><nlm:aff id="Aff1">Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, SW3 6JJ UK</nlm:aff><wicri:noCountry code="subfield">SW3 6JJ UK</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Thway, Khin" sort="Thway, Khin" uniqKey="Thway K" first="Khin" last="Thway">Khin Thway</name><affiliation><nlm:aff id="Aff1">Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, SW3 6JJ UK</nlm:aff><wicri:noCountry code="subfield">SW3 6JJ UK</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Head and Neck Pathology</title><idno type="ISSN">1936-055X</idno><idno type="eISSN">1936-0568</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Composite hemangioendothelioma (HE) is a rare vascular neoplasm of intermediate malignant potential that predominantly occurs within the dermis or subcutis of the extremities, and occurs in a wide age range.
It is locally aggressive with a high rate of local recurrence, and more rarely regional lymph node or distant metastasis. Histologically, it is composed of a complex admixture of benign, intermediate and malignant vascular components. Although composite HE may contain angiosarcoma-like areas, its prognosis is better than that of pure angiosarcoma. We describe a case of composite HE presenting as a submandibular mass in a 43 year-old male, which included areas of prominent ‘high grade’ epithelioid angiosarcoma. This adds to the range of anatomic sites of these neoplasms, highlights the importance of recognition of the head and neck as a potential site, and emphasizes the importance of accurate diagnosis for correct management (including of long term follow up) and prognostication.</p></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Leen, Sarah Lam Shang" sort="Leen, Sarah Lam Shang" uniqKey="Leen S" first="Sarah Lam Shang" last="Leen">Sarah Lam Shang Leen</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Clarke, Peter M" sort="Clarke, Peter M" uniqKey="Clarke P" first="Peter M." last="Clarke">Peter M. Clarke</name></region><name sortKey="Chapman, John" sort="Chapman, John" uniqKey="Chapman J" first="John" last="Chapman">John Chapman</name><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name><name sortKey="Thway, Khin" sort="Thway, Khin" uniqKey="Thway K" first="Khin" last="Thway">Khin Thway</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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