Everolimus plus mycophenolate mofetil as initial immunosuppression in liver transplantation.
Identifieur interne : 006F90 ( Ncbi/Checkpoint ); précédent : 006F89; suivant : 006F91Everolimus plus mycophenolate mofetil as initial immunosuppression in liver transplantation.
Auteurs : M. Jiménez-Pérez [Espagne] ; R. González Grande [Espagne] ; F J Rando Mu Oz [Espagne] ; J. De La Cruz Lombardo [Espagne] ; M A Mu Oz Suárez [Espagne] ; J L Fernández Aguilar [Espagne] ; J A Pérez Daga [Espagne] ; J. Santoyo-Santoyo [Espagne] ; R. Manteca González [Espagne] ; J M Rodrigo L Pez [Espagne]Source :
- Transplantation proceedings [ 1873-2623 ]
Descripteurs français
- KwdFr :
- Acide mycophénolique (analogues et dérivés), Acide mycophénolique (usage thérapeutique), Adulte, Adulte d'âge moyen, Association de médicaments, Carcinome hépatocellulaire (), Femelle, Humains, Immunosuppresseurs (usage thérapeutique), Mâle, Rejet du greffon (), Résultat thérapeutique, Sirolimus (analogues et dérivés), Sirolimus (usage thérapeutique), Sujet âgé, Tacrolimus (usage thérapeutique), Transplantation hépatique, Tumeurs du foie (), Études de suivi, Évérolimus.
- MESH :
- analogues et dérivés : Acide mycophénolique, Sirolimus.
- usage thérapeutique : Acide mycophénolique, Immunosuppresseurs, Sirolimus, Tacrolimus.
- Adulte, Adulte d'âge moyen, Association de médicaments, Carcinome hépatocellulaire, Femelle, Humains, Mâle, Rejet du greffon, Résultat thérapeutique, Sujet âgé, Transplantation hépatique, Tumeurs du foie, Études de suivi, Évérolimus.
English descriptors
- KwdEn :
- Adult, Aged, Carcinoma, Hepatocellular (surgery), Drug Therapy, Combination, Everolimus, Female, Follow-Up Studies, Graft Rejection (prevention & control), Humans, Immunosuppressive Agents (therapeutic use), Liver Neoplasms (surgery), Liver Transplantation, Male, Middle Aged, Mycophenolic Acid (analogs & derivatives), Mycophenolic Acid (therapeutic use), Sirolimus (analogs & derivatives), Sirolimus (therapeutic use), Tacrolimus (therapeutic use), Treatment Outcome.
- MESH :
- chemical , analogs & derivatives : Mycophenolic Acid, Sirolimus.
- chemical , therapeutic use : Immunosuppressive Agents, Mycophenolic Acid, Sirolimus, Tacrolimus.
- chemical : Everolimus.
- prevention & control : Graft Rejection.
- surgery : Carcinoma, Hepatocellular, Liver Neoplasms.
- Adult, Aged, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Liver Transplantation, Male, Middle Aged, Treatment Outcome.
Abstract
The purpose of this study was to assess the efficacy and safety of a de novo immunosuppressive regimen with everolimus (EVL) plus mycophenolate mofetil (MMF) without calcineurin inhibitors (CNI) for liver transplantation. The secondary purpose was to compare the renal function with a control group of patients treated with tacrolimus plus MMF.
DOI: 10.1016/j.transproceed.2014.11.005
PubMed: 25645779
Affiliations:
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pubmed:25645779Le document en format XML
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Santoyo-Santoyo</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Manteca Gonzalez, R" sort="Manteca Gonzalez, R" uniqKey="Manteca Gonzalez R" first="R" last="Manteca González">R. Manteca González</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Rodrigo L Pez, J M" sort="Rodrigo L Pez, J M" uniqKey="Rodrigo L Pez J" first="J M" last="Rodrigo L Pez">J M Rodrigo L Pez</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2015 Jan-Feb</MedlineDate></PubDate></date><idno type="RBID">pubmed:25645779</idno><idno type="pmid">25645779</idno><idno type="doi">10.1016/j.transproceed.2014.11.005</idno><idno type="wicri:Area/PubMed/Corpus">001066</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001066</idno><idno type="wicri:Area/PubMed/Curation">001066</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001066</idno><idno type="wicri:Area/PubMed/Checkpoint">001066</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001066</idno><idno type="wicri:Area/Ncbi/Merge">006F90</idno><idno type="wicri:Area/Ncbi/Curation">006F90</idno><idno type="wicri:Area/Ncbi/Checkpoint">006F90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Everolimus plus mycophenolate mofetil as initial immunosuppression in liver transplantation.</title><author><name sortKey="Jimenez Perez, M" sort="Jimenez Perez, M" uniqKey="Jimenez Perez M" first="M" last="Jiménez-Pérez">M. Jiménez-Pérez</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain. Electronic address: mjimenezp@commalaga.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Grande, R" sort="Gonzalez Grande, R" uniqKey="Gonzalez Grande R" first="R" last="González Grande">R. González Grande</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Rando Mu Oz, F J" sort="Rando Mu Oz, F J" uniqKey="Rando Mu Oz F" first="F J" last="Rando Mu Oz">F J Rando Mu Oz</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="De La Cruz Lombardo, J" sort="De La Cruz Lombardo, J" uniqKey="De La Cruz Lombardo J" first="J" last="De La Cruz Lombardo">J. De La Cruz Lombardo</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Mu Oz Suarez, M A" sort="Mu Oz Suarez, M A" uniqKey="Mu Oz Suarez M" first="M A" last="Mu Oz Suárez">M A Mu Oz Suárez</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Aguilar, J L" sort="Fernandez Aguilar, J L" uniqKey="Fernandez Aguilar J" first="J L" last="Fernández Aguilar">J L Fernández Aguilar</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Perez Daga, J A" sort="Perez Daga, J A" uniqKey="Perez Daga J" first="J A" last="Pérez Daga">J A Pérez Daga</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Santoyo Santoyo, J" sort="Santoyo Santoyo, J" uniqKey="Santoyo Santoyo J" first="J" last="Santoyo-Santoyo">J. Santoyo-Santoyo</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Cirugía HB y Trasplante Hepático, UGC de Cirugía Digestiva, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Manteca Gonzalez, R" sort="Manteca Gonzalez, R" uniqKey="Manteca Gonzalez R" first="R" last="Manteca González">R. Manteca González</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Rodrigo L Pez, J M" sort="Rodrigo L Pez, J M" uniqKey="Rodrigo L Pez J" first="J M" last="Rodrigo L Pez">J M Rodrigo L Pez</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Hepatología-Trasplante Hepático, UGC de Aparato Digestivo, Hospital Regional Universitario de Málaga</wicri:regionArea><wicri:noRegion>Hospital Regional Universitario de Málaga</wicri:noRegion></affiliation></author></analytic><series><title level="j">Transplantation proceedings</title><idno type="eISSN">1873-2623</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Carcinoma, Hepatocellular (surgery)</term><term>Drug Therapy, Combination</term><term>Everolimus</term><term>Female</term><term>Follow-Up Studies</term><term>Graft Rejection (prevention & control)</term><term>Humans</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Liver Neoplasms (surgery)</term><term>Liver Transplantation</term><term>Male</term><term>Middle Aged</term><term>Mycophenolic Acid (analogs & derivatives)</term><term>Mycophenolic Acid (therapeutic use)</term><term>Sirolimus (analogs & derivatives)</term><term>Sirolimus (therapeutic use)</term><term>Tacrolimus (therapeutic use)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide mycophénolique (analogues et dérivés)</term><term>Acide mycophénolique (usage thérapeutique)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Carcinome hépatocellulaire ()</term><term>Femelle</term><term>Humains</term><term>Immunosuppresseurs (usage thérapeutique)</term><term>Mâle</term><term>Rejet du greffon ()</term><term>Résultat thérapeutique</term><term>Sirolimus (analogues et dérivés)</term><term>Sirolimus (usage thérapeutique)</term><term>Sujet âgé</term><term>Tacrolimus (usage thérapeutique)</term><term>Transplantation hépatique</term><term>Tumeurs du foie ()</term><term>Études de suivi</term><term>Évérolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Mycophenolic Acid</term><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term><term>Mycophenolic Acid</term><term>Sirolimus</term><term>Tacrolimus</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Everolimus</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide mycophénolique</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acide mycophénolique</term><term>Immunosuppresseurs</term><term>Sirolimus</term><term>Tacrolimus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Drug Therapy, Combination</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Liver Transplantation</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Carcinome hépatocellulaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Rejet du greffon</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Transplantation hépatique</term><term>Tumeurs du foie</term><term>Études de suivi</term><term>Évérolimus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to assess the efficacy and safety of a de novo immunosuppressive regimen with everolimus (EVL) plus mycophenolate mofetil (MMF) without calcineurin inhibitors (CNI) for liver transplantation. The secondary purpose was to compare the renal function with a control group of patients treated with tacrolimus plus MMF.</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Jimenez Perez, M" sort="Jimenez Perez, M" uniqKey="Jimenez Perez M" first="M" last="Jiménez-Pérez">M. Jiménez-Pérez</name></noRegion><name sortKey="De La Cruz Lombardo, J" sort="De La Cruz Lombardo, J" uniqKey="De La Cruz Lombardo J" first="J" last="De La Cruz Lombardo">J. De La Cruz Lombardo</name><name sortKey="Fernandez Aguilar, J L" sort="Fernandez Aguilar, J L" uniqKey="Fernandez Aguilar J" first="J L" last="Fernández Aguilar">J L Fernández Aguilar</name><name sortKey="Gonzalez Grande, R" sort="Gonzalez Grande, R" uniqKey="Gonzalez Grande R" first="R" last="González Grande">R. González Grande</name><name sortKey="Manteca Gonzalez, R" sort="Manteca Gonzalez, R" uniqKey="Manteca Gonzalez R" first="R" last="Manteca González">R. Manteca González</name><name sortKey="Mu Oz Suarez, M A" sort="Mu Oz Suarez, M A" uniqKey="Mu Oz Suarez M" first="M A" last="Mu Oz Suárez">M A Mu Oz Suárez</name><name sortKey="Perez Daga, J A" sort="Perez Daga, J A" uniqKey="Perez Daga J" first="J A" last="Pérez Daga">J A Pérez Daga</name><name sortKey="Rando Mu Oz, F J" sort="Rando Mu Oz, F J" uniqKey="Rando Mu Oz F" first="F J" last="Rando Mu Oz">F J Rando Mu Oz</name><name sortKey="Rodrigo L Pez, J M" sort="Rodrigo L Pez, J M" uniqKey="Rodrigo L Pez J" first="J M" last="Rodrigo L Pez">J M Rodrigo L Pez</name><name sortKey="Santoyo Santoyo, J" sort="Santoyo Santoyo, J" uniqKey="Santoyo Santoyo J" first="J" last="Santoyo-Santoyo">J. Santoyo-Santoyo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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