Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps
Identifieur interne : 006E65 ( Ncbi/Checkpoint ); précédent : 006E64; suivant : 006E66Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps
Auteurs : R. M. Dongaonkar [États-Unis] ; T. L. Nguyen [États-Unis] ; C. M. Quick [États-Unis] ; C. L. Heaps [États-Unis] ; J. Hardy [États-Unis] ; G. A. Laine [États-Unis] ; E. Wilson [États-Unis] ; R. H. Stewart [États-Unis]Source :
- American Journal of Physiology - Regulatory, Integrative and Comparative Physiology [ 0363-6119 ] ; 2014.
Abstract
Lymphangions, the segments of lymphatic vessels between two adjacent lymphatic valves, actively pump lymph. Acute changes in transmural pressure and lymph flow have profound effects on lymphatic pump function in vitro. Chronic changes in pressure and flow in vivo have also been reported to lead to significant changes in lymphangion function. Because changes in pressure and flow are both cause and effect of adaptive processes, characterizing adaptation requires a more fundamental analysis of lymphatic muscle properties. Therefore, the purpose of the present work was to use an intact lymphangion isovolumetric preparation to evaluate changes in mesenteric lymphatic muscle mechanical properties and the intracellular Ca2+ in response to sustained mesenteric venous hypertension. Bovine mesenteric veins were surgically occluded to create mesenteric venous hypertension. Postnodal mesenteric lymphatic vessels from mesenteric venous hypertension (MVH;
Url:
DOI: 10.1152/ajpregu.00196.2014
PubMed: 25519727
PubMed Central: 4346757
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002B96
- to stream Pmc, to step Curation: 002B95
- to stream Pmc, to step Checkpoint: 001A00
- to stream Ncbi, to step Merge: 006E65
- to stream Ncbi, to step Curation: 006E65
Links to Exploration step
PMC:4346757Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps</title>
<author><name sortKey="Dongaonkar, R M" sort="Dongaonkar, R M" uniqKey="Dongaonkar R" first="R. M." last="Dongaonkar">R. M. Dongaonkar</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nguyen, T L" sort="Nguyen, T L" uniqKey="Nguyen T" first="T. L." last="Nguyen">T. L. Nguyen</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Quick, C M" sort="Quick, C M" uniqKey="Quick C" first="C. M." last="Quick">C. M. Quick</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Heaps, C L" sort="Heaps, C L" uniqKey="Heaps C" first="C. L." last="Heaps">C. L. Heaps</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J." last="Hardy">J. Hardy</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff2">Large Animal Clinical Sciences, Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Large Animal Clinical Sciences, Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Laine, G A" sort="Laine, G A" uniqKey="Laine G" first="G. A." last="Laine">G. A. Laine</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wilson, E" sort="Wilson, E" uniqKey="Wilson E" first="E." last="Wilson">E. Wilson</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Department of Medical Physiology, Texas A&M Health Science Center, Texas A&M University, College Station, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Medical Physiology, Texas A&M Health Science Center, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stewart, R H" sort="Stewart, R H" uniqKey="Stewart R" first="R. H." last="Stewart">R. H. Stewart</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25519727</idno>
<idno type="pmc">4346757</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346757</idno>
<idno type="RBID">PMC:4346757</idno>
<idno type="doi">10.1152/ajpregu.00196.2014</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">002B96</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B96</idno>
<idno type="wicri:Area/Pmc/Curation">002B95</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B95</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001A00</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A00</idno>
<idno type="wicri:Area/Ncbi/Merge">006E65</idno>
<idno type="wicri:Area/Ncbi/Curation">006E65</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">006E65</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps</title>
<author><name sortKey="Dongaonkar, R M" sort="Dongaonkar, R M" uniqKey="Dongaonkar R" first="R. M." last="Dongaonkar">R. M. Dongaonkar</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nguyen, T L" sort="Nguyen, T L" uniqKey="Nguyen T" first="T. L." last="Nguyen">T. L. Nguyen</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Quick, C M" sort="Quick, C M" uniqKey="Quick C" first="C. M." last="Quick">C. M. Quick</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Heaps, C L" sort="Heaps, C L" uniqKey="Heaps C" first="C. L." last="Heaps">C. L. Heaps</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J." last="Hardy">J. Hardy</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff2">Large Animal Clinical Sciences, Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Large Animal Clinical Sciences, Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Laine, G A" sort="Laine, G A" uniqKey="Laine G" first="G. A." last="Laine">G. A. Laine</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wilson, E" sort="Wilson, E" uniqKey="Wilson E" first="E." last="Wilson">E. Wilson</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Department of Medical Physiology, Texas A&M Health Science Center, Texas A&M University, College Station, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Medical Physiology, Texas A&M Health Science Center, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stewart, R H" sort="Stewart, R H" uniqKey="Stewart R" first="R. H." last="Stewart">R. H. Stewart</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Michael E. DeBakey Institute, Texas A&M University, College Station, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Michael E. DeBakey Institute, Texas A&M University, College Station</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">American Journal of Physiology - Regulatory, Integrative and Comparative Physiology</title>
<idno type="ISSN">0363-6119</idno>
<idno type="eISSN">1522-1490</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Lymphangions, the segments of lymphatic vessels between two adjacent lymphatic valves, actively pump lymph. Acute changes in transmural pressure and lymph flow have profound effects on lymphatic pump function in vitro. Chronic changes in pressure and flow in vivo have also been reported to lead to significant changes in lymphangion function. Because changes in pressure and flow are both cause and effect of adaptive processes, characterizing adaptation requires a more fundamental analysis of lymphatic muscle properties. Therefore, the purpose of the present work was to use an intact lymphangion isovolumetric preparation to evaluate changes in mesenteric lymphatic muscle mechanical properties and the intracellular Ca<sup>2+</sup>
in response to sustained mesenteric venous hypertension. Bovine mesenteric veins were surgically occluded to create mesenteric venous hypertension. Postnodal mesenteric lymphatic vessels from mesenteric venous hypertension (MVH; <italic>n</italic>
= 6) and sham surgery (Sham; <italic>n</italic>
= 6) animals were isolated and evaluated 3 days after the surgery. Spontaneously contracting MVH vessels generated end-systolic active tension and end-diastolic active tension lower than the Sham vessels. Furthermore, steady-state active tension and intracellular Ca<sup>2+</sup>
concentration levels in response to KCl stimulation were also significantly lower in MVH vessels compared with those of the Sham vessels. There was no significant difference in passive tension in lymphatic vessels from the two groups. Taken together, these results suggest that following 3 days of mesenteric venous hypertension, postnodal mesenteric lymphatic vessels adapt to become weaker pumps with decreased cytosolic Ca<sup>2+</sup>
concentration.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Texas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Dongaonkar, R M" sort="Dongaonkar, R M" uniqKey="Dongaonkar R" first="R. M." last="Dongaonkar">R. M. Dongaonkar</name>
</region>
<name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J." last="Hardy">J. Hardy</name>
<name sortKey="Heaps, C L" sort="Heaps, C L" uniqKey="Heaps C" first="C. L." last="Heaps">C. L. Heaps</name>
<name sortKey="Laine, G A" sort="Laine, G A" uniqKey="Laine G" first="G. A." last="Laine">G. A. Laine</name>
<name sortKey="Nguyen, T L" sort="Nguyen, T L" uniqKey="Nguyen T" first="T. L." last="Nguyen">T. L. Nguyen</name>
<name sortKey="Quick, C M" sort="Quick, C M" uniqKey="Quick C" first="C. M." last="Quick">C. M. Quick</name>
<name sortKey="Stewart, R H" sort="Stewart, R H" uniqKey="Stewart R" first="R. H." last="Stewart">R. H. Stewart</name>
<name sortKey="Wilson, E" sort="Wilson, E" uniqKey="Wilson E" first="E." last="Wilson">E. Wilson</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006E65 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 006E65 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:4346757 |texte= Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:25519727" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |