Spatio-Temporal Changes of Lymphatic Contractility and Drainage Patterns following Lymphadenectomy in Mice
Identifieur interne : 006A46 ( Ncbi/Checkpoint ); précédent : 006A45; suivant : 006A47Spatio-Temporal Changes of Lymphatic Contractility and Drainage Patterns following Lymphadenectomy in Mice
Auteurs : Sunkuk Kwon [États-Unis] ; Germaine D. Agollah [États-Unis] ; Grace Wu [États-Unis] ; Eva M. Sevick-Muraca [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Colorants fluorescents (), Diagnostic par imagerie, Facteurs temps, Femelle, Lignée cellulaire tumorale, Lymphadénectomie (), Lymphoedème (anatomopathologie), Lymphoedème (physiopathologie), Mélanome expérimental (anatomopathologie), Mélanome expérimental (physiopathologie), Métastase lymphatique, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (physiopathologie), Régénération, Souris de lignée C57BL, Système lymphatique (anatomopathologie), Système lymphatique (physiopathologie), Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (physiopathologie), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- anatomopathologie : Lymphoedème, Mélanome expérimental, Noeuds lymphatiques, Système lymphatique, Tumeurs cutanées, Vaisseaux lymphatiques.
- physiopathologie : Lymphoedème, Mélanome expérimental, Noeuds lymphatiques, Système lymphatique, Tumeurs cutanées, Vaisseaux lymphatiques.
- Animaux, Colorants fluorescents, Diagnostic par imagerie, Facteurs temps, Femelle, Lignée cellulaire tumorale, Lymphadénectomie, Métastase lymphatique, Régénération, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Cell Line, Tumor, Diagnostic Imaging, Female, Fluorescent Dyes (chemistry), Lymph Node Excision (methods), Lymph Nodes (pathology), Lymph Nodes (physiopathology), Lymphatic Metastasis, Lymphatic System (pathology), Lymphatic System (physiopathology), Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (pathology), Lymphedema (physiopathology), Melanoma, Experimental (pathology), Melanoma, Experimental (physiopathology), Mice, Inbred C57BL, Regeneration, Skin Neoplasms (pathology), Skin Neoplasms (physiopathology), Time Factors.
- MESH :
- chemical , chemistry : Fluorescent Dyes.
- methods : Lymph Node Excision.
- pathology : Lymph Nodes, Lymphatic System, Lymphatic Vessels, Lymphedema, Melanoma, Experimental, Skin Neoplasms.
- physiopathology : Lymph Nodes, Lymphatic System, Lymphatic Vessels, Lymphedema, Melanoma, Experimental, Skin Neoplasms.
- Animals, Cell Line, Tumor, Diagnostic Imaging, Female, Lymphatic Metastasis, Mice, Inbred C57BL, Regeneration, Time Factors.
Abstract
To investigate the redirection of lymphatic drainage post-lymphadenectomy using non-invasive near-infrared fluorescence (NIRF) imaging, and to subsequently assess impact on metastasis.
Cancer-acquired lymphedema arises from dysfunctional fluid transport after lymphadenectomy performed for staging and to disrupt drainage pathways for regional control of disease. However, little is known about the normal regenerative processes of the lymphatics in response to lymphadenectomy and how these responses can be accelerated, delayed, or can impact metastasis.
Changes in lymphatic “pumping” function and drainage patterns were non-invasively and longitudinally imaged using NIRF lymphatic imaging after popliteal lymphadenectomy in mice. In a cohort of mice, B16F10 melanoma was inoculated on the dorsal aspect of the paw 27 days after lymphadenectomy to assess how drainage patterns affect metastasis.
NIRF imaging demonstrates that, although lymphatic function and drainage patterns change significantly in early response to popliteal lymph node (PLN) removal in mice, these changes are transient and regress dramatically due to a high regenerative capacity of the lymphatics and co-opting of collateral lymphatic pathways around the site of obstruction. Metastases followed the pattern of collateral pathways and could be detected proximal to the site of lymphadenectomy.
Both lymphatic vessel regeneration and co-opting of contralateral vessels occur following lymphadenectomy, with contractile function restored within 13 days, providing a basis for preclinical and clinical investigations to hasten lymphatic repair and restore contractile lymphatic function after surgery to prevent cancer-acquired lymphedema. Patterns of cancer metastasis after lymphadenectomy were altered, consistent with patterns of re-directed lymphatic drainage.
Url:
DOI: 10.1371/journal.pone.0106034
PubMed: 25170770
PubMed Central: 4149501
Affiliations:
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Agollah</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Wu, Grace" sort="Wu, Grace" uniqKey="Wu G" first="Grace" last="Wu">Grace Wu</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M." last="Sevick-Muraca">Eva M. Sevick-Muraca</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Diagnostic Imaging</term><term>Female</term><term>Fluorescent Dyes (chemistry)</term><term>Lymph Node Excision (methods)</term><term>Lymph Nodes (pathology)</term><term>Lymph Nodes (physiopathology)</term><term>Lymphatic Metastasis</term><term>Lymphatic System (pathology)</term><term>Lymphatic System (physiopathology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Melanoma, Experimental (pathology)</term><term>Melanoma, Experimental (physiopathology)</term><term>Mice, Inbred C57BL</term><term>Regeneration</term><term>Skin Neoplasms (pathology)</term><term>Skin Neoplasms (physiopathology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Colorants fluorescents ()</term><term>Diagnostic par imagerie</term><term>Facteurs temps</term><term>Femelle</term><term>Lignée cellulaire tumorale</term><term>Lymphadénectomie ()</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (physiopathologie)</term><term>Mélanome expérimental (anatomopathologie)</term><term>Mélanome expérimental (physiopathologie)</term><term>Métastase lymphatique</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (physiopathologie)</term><term>Régénération</term><term>Souris de lignée C57BL</term><term>Système lymphatique (anatomopathologie)</term><term>Système lymphatique (physiopathologie)</term><term>Tumeurs cutanées (anatomopathologie)</term><term>Tumeurs cutanées (physiopathologie)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (physiopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorescent Dyes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Mélanome expérimental</term><term>Noeuds lymphatiques</term><term>Système lymphatique</term><term>Tumeurs cutanées</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymph Node Excision</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Melanoma, Experimental</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Mélanome expérimental</term><term>Noeuds lymphatiques</term><term>Système lymphatique</term><term>Tumeurs cutanées</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymph Nodes</term><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Melanoma, Experimental</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Diagnostic Imaging</term><term>Female</term><term>Lymphatic Metastasis</term><term>Mice, Inbred C57BL</term><term>Regeneration</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Colorants fluorescents</term><term>Diagnostic par imagerie</term><term>Facteurs temps</term><term>Femelle</term><term>Lignée cellulaire tumorale</term><term>Lymphadénectomie</term><term>Métastase lymphatique</term><term>Régénération</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To investigate the redirection of lymphatic drainage post-lymphadenectomy using non-invasive near-infrared fluorescence (NIRF) imaging, and to subsequently assess impact on metastasis.</p></sec><sec><title>Background</title><p>Cancer-acquired lymphedema arises from dysfunctional fluid transport after lymphadenectomy performed for staging and to disrupt drainage pathways for regional control of disease. However, little is known about the normal regenerative processes of the lymphatics in response to lymphadenectomy and how these responses can be accelerated, delayed, or can impact metastasis.</p></sec><sec><title>Methods</title><p>Changes in lymphatic “pumping” function and drainage patterns were non-invasively and longitudinally imaged using NIRF lymphatic imaging after popliteal lymphadenectomy in mice. In a cohort of mice, B16F10 melanoma was inoculated on the dorsal aspect of the paw 27 days after lymphadenectomy to assess how drainage patterns affect metastasis.</p></sec><sec><title>Results</title><p>NIRF imaging demonstrates that, although lymphatic function and drainage patterns change significantly in early response to popliteal lymph node (PLN) removal in mice, these changes are transient and regress dramatically due to a high regenerative capacity of the lymphatics and co-opting of collateral lymphatic pathways around the site of obstruction. Metastases followed the pattern of collateral pathways and could be detected proximal to the site of lymphadenectomy.</p></sec><sec><title>Conclusions</title><p>Both lymphatic vessel regeneration and co-opting of contralateral vessels occur following lymphadenectomy, with contractile function restored within 13 days, providing a basis for preclinical and clinical investigations to hasten lymphatic repair and restore contractile lymphatic function after surgery to prevent cancer-acquired lymphedema. Patterns of cancer metastasis after lymphadenectomy were altered, consistent with patterns of re-directed lymphatic drainage.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Szuba, A" uniqKey="Szuba A">A Szuba</name></author><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cormier, Jn" uniqKey="Cormier J">JN Cormier</name></author><author><name sortKey="Askew, Rl" uniqKey="Askew R">RL Askew</name></author><author><name sortKey="Mungovan, Ks" uniqKey="Mungovan K">KS Mungovan</name></author><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y Xing</name></author><author><name sortKey="Ross, Mi" uniqKey="Ross M">MI Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawenda, Bd" uniqKey="Lawenda B">BD Lawenda</name></author><author><name sortKey="Mondry, Te" uniqKey="Mondry T">TE Mondry</name></author><author><name sortKey="Johnstone, Pa" uniqKey="Johnstone P">PA Johnstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paskett, Ed" uniqKey="Paskett E">ED Paskett</name></author><author><name sortKey="Dean, Ja" uniqKey="Dean J">JA Dean</name></author><author><name sortKey="Oliveri, Jm" uniqKey="Oliveri J">JM Oliveri</name></author><author><name sortKey="Harrop, Jp" uniqKey="Harrop J">JP 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Narushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Unno, N" uniqKey="Unno N">N Unno</name></author><author><name sortKey="Inuzuka, K" uniqKey="Inuzuka K">K Inuzuka</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Yamamoto, N" uniqKey="Yamamoto N">N Yamamoto</name></author><author><name sortKey="Sagara, D" uniqKey="Sagara D">D Sagara</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name></region><name sortKey="Agollah, Germaine D" sort="Agollah, Germaine D" uniqKey="Agollah G" first="Germaine D." last="Agollah">Germaine D. Agollah</name><name sortKey="Agollah, Germaine D" sort="Agollah, Germaine D" uniqKey="Agollah G" first="Germaine D." last="Agollah">Germaine D. Agollah</name><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M." last="Sevick-Muraca">Eva M. Sevick-Muraca</name><name sortKey="Wu, Grace" sort="Wu, Grace" uniqKey="Wu G" first="Grace" last="Wu">Grace Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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