Lymphangiogenesis and Angiogenesis in Abdominal Aortic Aneurysm
Identifieur interne : 006450 ( Ncbi/Checkpoint ); précédent : 006449; suivant : 006451Lymphangiogenesis and Angiogenesis in Abdominal Aortic Aneurysm
Auteurs : Masaki Sano [Japon] ; Takeshi Sasaki [Japon] ; Satoshi Hirakawa [Japon] ; Junichi Sakabe [Japon] ; Mikako Ogawa [Japon] ; Satoshi Baba [Japon] ; Nobuhiro Zaima [Japon] ; Hiroki Tanaka [Japon] ; Kazunori Inuzuka [Japon] ; Naoto Yamamoto [Japon] ; Mitsutoshi Setou [Japon] ; Kohji Sato [Japon] ; Hiroyuki Konno [Japon] ; Naoki Unno [Japon]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration of vascular wall. Neovascularization is regularly found in human AAA and considered to play critical roles in the development and rupture of AAA. However, little is known about lymphangiogenesis in AAA. The purpose of this study was to demonstrate both angiogenesis and lymphangiogenesis in AAA. Abdominal aortic tissue was harvested either from autopsy (control group) and during open-repair surgery for AAA (AAA group). Adventitial lymphatic vasa vasorum was observed in both groups, but seemed to be no significant morphological changes in AAA. Immunohistochemical studies identified infiltration of lymphatic vessel endothelial hyaluronan receptor (LYVE) −1, vascular endothelial growth factor (VEGF)-C, and matrix metalloproteinase (MMP)-9-positive macrophages and podoplanin and Prox-1-positive microvessels in the intima/media in AAA wall, where hypoxia-inducible factors (HIF)-1α was expressed. VEGF-C and MMP-9 were not expressed in macrophages infiltrating in the adventitia. Intraoperative indocyanine green fluorescence lymphography revealed lymph stasis in intima/medial in AAA. Fluorescence microscopy of the collected samples also confirmed the accumulation of lymph in the intima/media but not in adventitia. These results demonstrate that infiltration of macrophages in intima/media is associated with lymphangiogenesis and angiogenesis in AAA. Lymph-drainage appeared to be insufficient in the AAA wall.
Url:
DOI: 10.1371/journal.pone.0089830
PubMed: 24651519
PubMed Central: 3961250
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xml:lang="fr">Japon</country><wicri:regionArea>Department of Applied Biological Chemistry, Kinki University, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Hiroki" sort="Tanaka, Hiroki" uniqKey="Tanaka H" first="Hiroki" last="Tanaka">Hiroki Tanaka</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country 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id="aff2"><addr-line>Department of Anatomy and Neuroscience, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anatomy and Neuroscience, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Konno, Hiroyuki" sort="Konno, Hiroyuki" uniqKey="Konno H" first="Hiroyuki" last="Konno">Hiroyuki Konno</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, 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xml:lang="fr">Japon</country><wicri:regionArea>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Anatomy and Neuroscience, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anatomy and Neuroscience, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Hirakawa, Satoshi" sort="Hirakawa, Satoshi" uniqKey="Hirakawa S" first="Satoshi" last="Hirakawa">Satoshi Hirakawa</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Dermatology, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Sakabe, Junichi" sort="Sakabe, Junichi" uniqKey="Sakabe J" first="Junichi" last="Sakabe">Junichi Sakabe</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Dermatology, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Ogawa, Mikako" sort="Ogawa, Mikako" uniqKey="Ogawa M" first="Mikako" last="Ogawa">Mikako Ogawa</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Molecular Imaging, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Imaging, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Baba, Satoshi" sort="Baba, Satoshi" uniqKey="Baba S" first="Satoshi" last="Baba">Satoshi Baba</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Zaima, Nobuhiro" sort="Zaima, Nobuhiro" uniqKey="Zaima N" first="Nobuhiro" last="Zaima">Nobuhiro Zaima</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Applied Biological Chemistry, Kinki University, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Applied Biological Chemistry, Kinki University, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Hiroki" sort="Tanaka, Hiroki" uniqKey="Tanaka H" first="Hiroki" last="Tanaka">Hiroki Tanaka</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Inuzuka, Kazunori" sort="Inuzuka, Kazunori" uniqKey="Inuzuka K" first="Kazunori" last="Inuzuka">Kazunori Inuzuka</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naoto" sort="Yamamoto, Naoto" uniqKey="Yamamoto N" first="Naoto" last="Yamamoto">Naoto Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Setou, Mitsutoshi" sort="Setou, Mitsutoshi" uniqKey="Setou M" first="Mitsutoshi" last="Setou">Mitsutoshi Setou</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Sato, Kohji" sort="Sato, Kohji" uniqKey="Sato K" first="Kohji" last="Sato">Kohji Sato</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Anatomy and Neuroscience, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anatomy and Neuroscience, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Konno, Hiroyuki" sort="Konno, Hiroyuki" uniqKey="Konno H" first="Hiroyuki" last="Konno">Hiroyuki Konno</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Unno, Naoki" sort="Unno, Naoki" uniqKey="Unno N" first="Naoki" last="Unno">Naoki Unno</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Applied Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu City, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration of vascular wall. Neovascularization is regularly found in human AAA and considered to play critical roles in the development and rupture of AAA. However, little is known about lymphangiogenesis in AAA. The purpose of this study was to demonstrate both angiogenesis and lymphangiogenesis in AAA. Abdominal aortic tissue was harvested either from autopsy (control group) and during open-repair surgery for AAA (AAA group). Adventitial lymphatic vasa vasorum was observed in both groups, but seemed to be no significant morphological changes in AAA. Immunohistochemical studies identified infiltration of lymphatic vessel endothelial hyaluronan receptor (LYVE) −1, vascular endothelial growth factor (VEGF)-C, and matrix metalloproteinase (MMP)-9-positive macrophages and podoplanin and Prox-1-positive microvessels in the intima/media in AAA wall, where hypoxia-inducible factors (HIF)-1α was expressed. VEGF-C and MMP-9 were not expressed in macrophages infiltrating in the adventitia. Intraoperative indocyanine green fluorescence lymphography revealed lymph stasis in intima/medial in AAA. Fluorescence microscopy of the collected samples also confirmed the accumulation of lymph in the intima/media but not in adventitia. These results demonstrate that infiltration of macrophages in intima/media is associated with lymphangiogenesis and angiogenesis in AAA. Lymph-drainage appeared to be insufficient in the AAA wall.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Baxter, Bt" uniqKey="Baxter B">BT Baxter</name></author><author><name sortKey="Terrin, Mc" uniqKey="Terrin M">MC Terrin</name></author><author><name sortKey="Dalman, Rl" uniqKey="Dalman R">RL Dalman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kajimoto, K" uniqKey="Kajimoto K">K Kajimoto</name></author><author><name sortKey="Miyauchi, K" uniqKey="Miyauchi K">K Miyauchi</name></author><author><name sortKey="Kasai, T" uniqKey="Kasai T">T Kasai</name></author><author><name sortKey="Shimada, K" uniqKey="Shimada K">K Shimada</name></author><author><name sortKey="Kojima, Y" uniqKey="Kojima Y">Y Kojima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindeman, Jh" uniqKey="Lindeman J">JH Lindeman</name></author><author><name sortKey="Abdul Hussien, H" 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Boyce</name></author><author><name sortKey="Liang, Q" uniqKey="Liang Q">Q Liang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Sano, Masaki" sort="Sano, Masaki" uniqKey="Sano M" first="Masaki" last="Sano">Masaki Sano</name></noRegion><name sortKey="Baba, Satoshi" sort="Baba, Satoshi" uniqKey="Baba S" first="Satoshi" last="Baba">Satoshi Baba</name><name sortKey="Hirakawa, Satoshi" sort="Hirakawa, Satoshi" uniqKey="Hirakawa S" first="Satoshi" last="Hirakawa">Satoshi Hirakawa</name><name sortKey="Inuzuka, Kazunori" sort="Inuzuka, Kazunori" uniqKey="Inuzuka K" first="Kazunori" last="Inuzuka">Kazunori Inuzuka</name><name sortKey="Inuzuka, Kazunori" sort="Inuzuka, Kazunori" uniqKey="Inuzuka K" first="Kazunori" last="Inuzuka">Kazunori Inuzuka</name><name sortKey="Konno, Hiroyuki" sort="Konno, Hiroyuki" uniqKey="Konno H" first="Hiroyuki" last="Konno">Hiroyuki Konno</name><name sortKey="Ogawa, Mikako" sort="Ogawa, Mikako" uniqKey="Ogawa M" first="Mikako" last="Ogawa">Mikako Ogawa</name><name sortKey="Sakabe, Junichi" sort="Sakabe, Junichi" uniqKey="Sakabe J" first="Junichi" last="Sakabe">Junichi Sakabe</name><name sortKey="Sano, Masaki" sort="Sano, Masaki" uniqKey="Sano M" first="Masaki" last="Sano">Masaki Sano</name><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name><name sortKey="Sato, Kohji" sort="Sato, Kohji" uniqKey="Sato K" first="Kohji" last="Sato">Kohji Sato</name><name sortKey="Setou, Mitsutoshi" sort="Setou, Mitsutoshi" uniqKey="Setou M" first="Mitsutoshi" last="Setou">Mitsutoshi Setou</name><name sortKey="Tanaka, Hiroki" sort="Tanaka, Hiroki" uniqKey="Tanaka H" first="Hiroki" last="Tanaka">Hiroki Tanaka</name><name sortKey="Tanaka, Hiroki" sort="Tanaka, Hiroki" uniqKey="Tanaka H" first="Hiroki" last="Tanaka">Hiroki Tanaka</name><name sortKey="Unno, Naoki" sort="Unno, Naoki" uniqKey="Unno N" first="Naoki" last="Unno">Naoki Unno</name><name sortKey="Unno, Naoki" sort="Unno, Naoki" uniqKey="Unno N" first="Naoki" last="Unno">Naoki Unno</name><name sortKey="Yamamoto, Naoto" sort="Yamamoto, Naoto" uniqKey="Yamamoto N" first="Naoto" last="Yamamoto">Naoto Yamamoto</name><name sortKey="Yamamoto, Naoto" sort="Yamamoto, Naoto" uniqKey="Yamamoto N" first="Naoto" last="Yamamoto">Naoto Yamamoto</name><name sortKey="Zaima, Nobuhiro" sort="Zaima, Nobuhiro" uniqKey="Zaima N" first="Nobuhiro" last="Zaima">Nobuhiro Zaima</name><name sortKey="Zaima, Nobuhiro" sort="Zaima, Nobuhiro" uniqKey="Zaima N" first="Nobuhiro" last="Zaima">Nobuhiro Zaima</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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