LymphedemaV1, Ncbi, Checkpoint, bibRecord, 005908

Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure

Identifieur interne : 005908 ( Ncbi/Checkpoint ); précédent : 005907; suivant : 005909

Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure

Auteurs : R. M. Dongaonkar [États-Unis] ; T. L. Nguyen [États-Unis] ; C. M. Quick [États-Unis] ; J. Hardy [États-Unis] ; G. A. Laine [États-Unis] ; E. Wilson [États-Unis] ; R. H. Stewart [États-Unis]

Source :

American Journal of Physiology - Heart and Circulatory Physiology [ 0363-6135 ] ; 2013.

RBID : PMC:3726955

Descripteurs français

KwdFr :
- Adaptation physiologique, Animaux, Bovins, Constriction, Contraction musculaire, Facteurs temps, Lymphoedème (physiopathologie), Mésentère, Pression, Vaisseaux lymphatiques (), Vaisseaux lymphatiques (anatomie et histologie), Vaisseaux lymphatiques (physiologie).
MESH :
- anatomie et histologie : Vaisseaux lymphatiques.
- physiologie : Vaisseaux lymphatiques.
- physiopathologie : Lymphoedème.
- Adaptation physiologique, Animaux, Bovins, Constriction, Contraction musculaire, Facteurs temps, Mésentère, Pression, Vaisseaux lymphatiques.

English descriptors

KwdEn :
- Adaptation, Physiological, Animals, Cattle, Constriction, Lymphatic Vessels (anatomy & histology), Lymphatic Vessels (physiology), Lymphatic Vessels (surgery), Lymphedema (physiopathology), Mesentery, Muscle Contraction, Pressure, Time Factors.
MESH :
- anatomy & histology : Lymphatic Vessels.
- physiology : Lymphatic Vessels.
- physiopathology : Lymphedema.
- surgery : Lymphatic Vessels.
- Adaptation, Physiological, Animals, Cattle, Constriction, Mesentery, Muscle Contraction, Pressure, Time Factors.

Abstract

In vitro studies have revealed that acute increases in transmural pressure increase lymphatic vessel contractile function. However, adaptive responses to prolonged changes in transmural pressure in vivo have not been reported. Therefore, we developed a novel bovine mesenteric lymphatic partial constriction model to test the hypothesis that lymphatic vessels exposed to higher transmural pressures adapt functionally to become stronger pumps than vessels exposed to lower transmural pressures. Postnodal mesenteric lymphatic vessels were partially constricted for 3 days. On postoperative day 3, constricted vessels were isolated, and divided into upstream (UP) and downstream (DN) segment groups, and instrumented in an isolated bath. Although there were no differences between the passive diameters of the two groups, both diastolic diameter and systolic diameter were significantly larger in the UP group than in the DN group. The pump index of the UP group was also higher than that in the DN group. In conclusion, this is the first work to report how lymphatic vessels adapt to prolonged changes in transmural pressure in vivo. Our results suggest that vessel segments upstream of the constriction adapt to become both better fluid conduits and lymphatic pumps than downstream segments.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726955

DOI: 10.1152/ajpheart.00677.2012
PubMed: 23666672
PubMed Central: 3726955

Affiliations:

Links to Exploration step

PMC:3726955

Le document en format XML

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<term>Lymphatic Vessels (physiology)</term>
<term>Lymphatic Vessels (surgery)</term>
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<term>Cattle</term>
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<term>Mesentery</term>
<term>Muscle Contraction</term>
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<term>Constriction</term>
<term>Contraction musculaire</term>
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<front><div type="abstract" xml:lang="en"><p>In vitro studies have revealed that acute increases in transmural pressure increase lymphatic vessel contractile function. However, adaptive responses to prolonged changes in transmural pressure in vivo have not been reported. Therefore, we developed a novel bovine mesenteric lymphatic partial constriction model to test the hypothesis that lymphatic vessels exposed to higher transmural pressures adapt functionally to become stronger pumps than vessels exposed to lower transmural pressures. Postnodal mesenteric lymphatic vessels were partially constricted for 3 days. On postoperative <italic>day 3</italic>
, constricted vessels were isolated, and divided into upstream (UP) and downstream (DN) segment groups, and instrumented in an isolated bath. Although there were no differences between the passive diameters of the two groups, both diastolic diameter and systolic diameter were significantly larger in the UP group than in the DN group. The pump index of the UP group was also higher than that in the DN group. In conclusion, this is the first work to report how lymphatic vessels adapt to prolonged changes in transmural pressure in vivo. Our results suggest that vessel segments upstream of the constriction adapt to become both better fluid conduits and lymphatic pumps than downstream segments.</p>
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Serveur d'exploration sur le lymphœdème

Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure

Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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