Radiation therapy in the management of Merkel cell carcinoma: current perspectives
Identifieur interne : 005806 ( Ncbi/Checkpoint ); précédent : 005805; suivant : 005807Radiation therapy in the management of Merkel cell carcinoma: current perspectives
Auteurs : Zoe Rush [États-Unis] ; Ryan C. Fields [États-Unis] ; Nancy Lee [États-Unis] ; Isaac Brownell [États-Unis]Source :
- Expert review of dermatology [ 1746-9872 ] ; 2011.
Abstract
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm with a propensity for metastatic spread. When managing MCC, surgical excision is often the initial treatment. As MCC is generally radiosensitive, many institutions include adjuvant radiation therapy (RT) in their standard treatment protocols. In the absence of prospective randomized clinical trials, a number of retrospective reports suggest that adjuvant RT can improve local and regional recurrence rates. Here, we provide an overview of recent studies on the use of RT in MCC treatment and explore the limits of the current knowledge. Ultimately, the benefits and risks associated with using RT in the treatment of MCC remain poorly described and merit more rigorous investigation.
Url:
DOI: 10.1586/edm.11.40
PubMed: 23565121
PubMed Central: 3615640
Affiliations:
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Fields</name><affiliation wicri:level="1"><nlm:aff id="A2">Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Nancy" sort="Lee, Nancy" uniqKey="Lee N" first="Nancy" last="Lee">Nancy Lee</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Brownell, Isaac" sort="Brownell, Isaac" uniqKey="Brownell I" first="Isaac" last="Brownell">Isaac Brownell</name><affiliation wicri:level="1"><nlm:aff id="A4">Dermatology Branch, Center for Cancer Research, NCI, NIH, Building 10, Magnuson Clinical Center, Room 12N246, 10, Center Dr., Bethesda, MD 20892-1908, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dermatology Branch, Center for Cancer Research, NCI, NIH, Building 10, Magnuson Clinical Center, Room 12N246, 10, Center Dr., Bethesda, MD 20892-1908</wicri:regionArea><wicri:noRegion>MD 20892-1908</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23565121</idno><idno type="pmc">3615640</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615640</idno><idno type="RBID">PMC:3615640</idno><idno type="doi">10.1586/edm.11.40</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">003530</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003530</idno><idno type="wicri:Area/Pmc/Curation">003529</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003529</idno><idno type="wicri:Area/Pmc/Checkpoint">002D75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002D75</idno><idno type="wicri:Area/Ncbi/Merge">005806</idno><idno type="wicri:Area/Ncbi/Curation">005806</idno><idno type="wicri:Area/Ncbi/Checkpoint">005806</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Radiation therapy in the management of Merkel cell carcinoma: current perspectives</title><author><name sortKey="Rush, Zoe" sort="Rush, Zoe" uniqKey="Rush Z" first="Zoe" last="Rush">Zoe Rush</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287</wicri:regionArea><wicri:noRegion>MD 21287</wicri:noRegion></affiliation></author><author><name sortKey="Fields, Ryan C" sort="Fields, Ryan C" uniqKey="Fields R" first="Ryan C" last="Fields">Ryan C. Fields</name><affiliation wicri:level="1"><nlm:aff id="A2">Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Nancy" sort="Lee, Nancy" uniqKey="Lee N" first="Nancy" last="Lee">Nancy Lee</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Brownell, Isaac" sort="Brownell, Isaac" uniqKey="Brownell I" first="Isaac" last="Brownell">Isaac Brownell</name><affiliation wicri:level="1"><nlm:aff id="A4">Dermatology Branch, Center for Cancer Research, NCI, NIH, Building 10, Magnuson Clinical Center, Room 12N246, 10, Center Dr., Bethesda, MD 20892-1908, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dermatology Branch, Center for Cancer Research, NCI, NIH, Building 10, Magnuson Clinical Center, Room 12N246, 10, Center Dr., Bethesda, MD 20892-1908</wicri:regionArea><wicri:noRegion>MD 20892-1908</wicri:noRegion></affiliation></author></analytic><series><title level="j">Expert review of dermatology</title><idno type="ISSN">1746-9872</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm with a propensity for metastatic spread. When managing MCC, surgical excision is often the initial treatment. As MCC is generally radiosensitive, many institutions include adjuvant radiation therapy (RT) in their standard treatment protocols. In the absence of prospective randomized clinical trials, a number of retrospective reports suggest that adjuvant RT can improve local and regional recurrence rates. Here, we provide an overview of recent studies on the use of RT in MCC treatment and explore the limits of the current knowledge. Ultimately, the benefits and risks associated with using RT in the treatment of MCC remain poorly described and merit more rigorous investigation.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Rush, Zoe" sort="Rush, Zoe" uniqKey="Rush Z" first="Zoe" last="Rush">Zoe Rush</name></noRegion><name sortKey="Brownell, Isaac" sort="Brownell, Isaac" uniqKey="Brownell I" first="Isaac" last="Brownell">Isaac Brownell</name><name sortKey="Fields, Ryan C" sort="Fields, Ryan C" uniqKey="Fields R" first="Ryan C" last="Fields">Ryan C. Fields</name><name sortKey="Lee, Nancy" sort="Lee, Nancy" uniqKey="Lee N" first="Nancy" last="Lee">Nancy Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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