Endothelial ERK signaling controls lymphatic fate specification
Identifieur interne : 005603 ( Ncbi/Checkpoint ); précédent : 005602; suivant : 005604Endothelial ERK signaling controls lymphatic fate specification
Auteurs : Yong Deng [États-Unis] ; Deepak Atri [États-Unis] ; Anne Eichmann [États-Unis, France] ; Michael Simons [États-Unis]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2013.
Abstract
Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducible expression of an
Url:
DOI: 10.1172/JCI63034
PubMed: 23391722
PubMed Central: 3582116
Affiliations:
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PMC:3582116Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducible expression of an <italic>RAF1</italic>
gene with a gain-of-function mutation (<italic>RAF1<sup>S259A</sup>
</italic>
) that is associated with Noonan syndrome. Expression of mutant <italic>RAF1<sup>S259A</sup>
</italic>
in ECs activated ERK and induced SOX18 and PROX1 expression, leading to increased commitment of venous ECs to the lymphatic fate. Excessive production of lymphatic ECs resulted in lymphangiectasia that was highly reminiscent of abnormal lymphatics seen in Noonan syndrome and similar “RASopathies.” Inhibition of ERK signaling during development abrogated the lymphatic differentiation program and rescued the lymphatic phenotypes induced by expression of <italic>RAF1<sup>S259A</sup>
</italic>
. These data suggest that ERK activation plays a key role in lymphatic EC fate specification and that excessive ERK activation is the basis of lymphatic abnormalities seen in Noonan syndrome and related diseases.
</p>
</div>
</front>
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