In Vivo Flow Cytometry: A Horizon of Opportunities
Identifieur interne : 004664 ( Ncbi/Checkpoint ); précédent : 004663; suivant : 004665In Vivo Flow Cytometry: A Horizon of Opportunities
Auteurs : Valery V. Tuchin [Russie] ; Attila Tárnok ; Vladimir P. Zharov [États-Unis]Source :
- Cytometry. Part A : the journal of the International Society for Analytical Cytology [ 1552-4922 ] ; 2011.
Abstract
Flow cytometry has been a fundamental tool of biological discovery for many years. Invasive extraction of cells from a living organism, however, may lead to changes in cell properties and prevents studying cells in their native environment. These problems can be overcome by use of
Url:
DOI: 10.1002/cyto.a.21143
PubMed: 21915991
PubMed Central: 3663136
Affiliations:
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<affiliation><nlm:aff id="A3">University of Oulu, Oulu, FI-90014 Finland</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="A1">Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia</nlm:aff>
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<series><title level="j">Cytometry. Part A : the journal of the International Society for Analytical Cytology</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Flow cytometry has been a fundamental tool of biological discovery for many years. Invasive extraction of cells from a living organism, however, may lead to changes in cell properties and prevents studying cells in their native environment. These problems can be overcome by use of <italic>in vivo</italic>
flow cytometry which provides detection and imaging of circulating normal and abnormal cells directlyin blood or lymph flow. The goal of this mini-review is to provide a brief history, features and challenges of this new generation of flow cytometry methods and instruments. Spectrum of possibilities of <italic>in vivo</italic>
flow cytometry in biological science (e.g., cell metabolism, immune function, or apoptosis) and medical fields (e.g., cancer, infection, cardiovascular disorder) including integrated photoacoustic-photothermal theranostics of circulating abnormal cells are discussed with focus on recent advances of this new platform.</p>
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