Mechanisms of chylomicron uptake into lacteals
Identifieur interne : 003E98 ( Ncbi/Checkpoint ); précédent : 003E97; suivant : 003E99Mechanisms of chylomicron uptake into lacteals
Auteurs : J. Brandon Dixon [Géorgie (pays)]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2010.
Abstract
Right from birth, the lymphatics play a crucial role in dietary functions. A majority of the lipid absorbed from the newborn’s lipid-rich diet enters the blood circulation through the lymphatic system, which transports triglyceride-loaded particles known as chylomicrons from the villi of the small intestine to the venous circulation near the heart. In light of the significance of this role, as well as the fact that lipid transport from the gut was one of the earliest discovered functions of the lymphatic vasculature, it is surprising that so little is known about how chylomicrons initially gain access to the lymphatic vessel. This review will focus on the current mechanisms thought to be important in this process and highlight important questions that need to be answered in the future.
Url:
DOI: 10.1111/j.1749-6632.2010.05716.x
PubMed: 20961306
PubMed Central: 3132563
Affiliations:
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Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea> Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20961306</idno><idno type="pmc">3132563</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132563</idno><idno type="RBID">PMC:3132563</idno><idno type="doi">10.1111/j.1749-6632.2010.05716.x</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002A04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A04</idno><idno type="wicri:Area/Pmc/Curation">002A03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A03</idno><idno type="wicri:Area/Pmc/Checkpoint">003328</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003328</idno><idno type="wicri:Area/Ncbi/Merge">003E98</idno><idno type="wicri:Area/Ncbi/Curation">003E98</idno><idno type="wicri:Area/Ncbi/Checkpoint">003E98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mechanisms of chylomicron uptake into lacteals</title><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><affiliation wicri:level="1"><nlm:aff id="A1"> George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea> George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea> Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea> Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Right from birth, the lymphatics play a crucial role in dietary functions. A majority of the lipid absorbed from the newborn’s lipid-rich diet enters the blood circulation through the lymphatic system, which transports triglyceride-loaded particles known as chylomicrons from the villi of the small intestine to the venous circulation near the heart. In light of the significance of this role, as well as the fact that lipid transport from the gut was one of the earliest discovered functions of the lymphatic vasculature, it is surprising that so little is known about how chylomicrons initially gain access to the lymphatic vessel. This review will focus on the current mechanisms thought to be important in this process and highlight important questions that need to be answered in the future.</p></div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li></country></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name></noRegion><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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