Intraoperative Multispectral Fluorescence Imaging for the Detection of the Sentinel Lymph Node in Cervical Cancer: A Novel Concept
Identifieur interne : 003D92 ( Ncbi/Checkpoint ); précédent : 003D91; suivant : 003D93Intraoperative Multispectral Fluorescence Imaging for the Detection of the Sentinel Lymph Node in Cervical Cancer: A Novel Concept
Auteurs : Lucia M. A. Crane [Pays-Bas] ; George Themelis [Allemagne] ; Rick G. Pleijhuis [Pays-Bas] ; Niels J. Harlaar [Pays-Bas, Allemagne] ; Athanasios Sarantopoulos [Allemagne] ; Henriette J. G. Arts [Pays-Bas] ; Ate G. J. Van Der Zee [Pays-Bas] ; Ntziachristos Vasilis [Allemagne] ; Gooitzen M. Van Dam [Pays-Bas]Source :
- Molecular Imaging and Biology [ 1536-1632 ] ; 2010.
Abstract
Real-time intraoperative near-infrared fluorescence (NIRF) imaging is a promising technique for lymphatic mapping and sentinel lymph node (SLN) detection. The purpose of this technical feasibility pilot study was to evaluate the applicability of NIRF imaging with indocyanin green (ICG) for the detection of the SLN in cervical cancer.
In ten patients with early stage cervical cancer, a mixture of patent blue and ICG was injected into the cervix uteri during surgery. Real-time color and fluorescence videos and images were acquired using a custom-made multispectral fluorescence camera system.
Real-time fluorescence lymphatic mapping was observed
We conclude that lymphatic mapping and detection of the SLN in cervical cancer using intraoperative NIRF imaging is technically feasible. However, the technique needs to be refined for full applicability in cervical cancer in terms of sensitivity and specificity.
The online version of this article (doi:10.1007/s11307-010-0425-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s11307-010-0425-7
PubMed: 20835767
PubMed Central: 3179588
Affiliations:
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A." last="Crane">Lucia M. A. Crane</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Surgery, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Themelis, George" sort="Themelis, George" uniqKey="Themelis G" first="George" last="Themelis">George Themelis</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Pleijhuis, Rick G" sort="Pleijhuis, Rick G" uniqKey="Pleijhuis R" first="Rick G." last="Pleijhuis">Rick G. Pleijhuis</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Surgery, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Harlaar, Niels J" sort="Harlaar, Niels J" uniqKey="Harlaar N" first="Niels J." last="Harlaar">Niels J. Harlaar</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Surgery, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Sarantopoulos, Athanasios" sort="Sarantopoulos, Athanasios" uniqKey="Sarantopoulos A" first="Athanasios" last="Sarantopoulos">Athanasios Sarantopoulos</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Arts, Henriette J G" sort="Arts, Henriette J G" uniqKey="Arts H" first="Henriette J. G." last="Arts">Henriette J. G. Arts</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Van Der Zee, Ate G J" sort="Van Der Zee, Ate G J" uniqKey="Van Der Zee A" first="Ate G. J." last="Van Der Zee">Ate G. J. Van Der Zee</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Vasilis, Ntziachristos" sort="Vasilis, Ntziachristos" uniqKey="Vasilis N" first="Ntziachristos" last="Vasilis">Ntziachristos Vasilis</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Van Dam, Gooitzen M" sort="Van Dam, Gooitzen M" uniqKey="Van Dam G" first="Gooitzen M." last="Van Dam">Gooitzen M. Van Dam</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Surgery, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Surgery, BioOptical Imaging Center Groningen (BICG), University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Surgery, BioOptical Imaging Center Groningen (BICG), University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Imaging and Biology</title><idno type="ISSN">1536-1632</idno><idno type="eISSN">1860-2002</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Real-time intraoperative near-infrared fluorescence (NIRF) imaging is a promising technique for lymphatic mapping and sentinel lymph node (SLN) detection. The purpose of this technical feasibility pilot study was to evaluate the applicability of NIRF imaging with indocyanin green (ICG) for the detection of the SLN in cervical cancer.</p></sec><sec><title>Procedures</title><p>In ten patients with early stage cervical cancer, a mixture of patent blue and ICG was injected into the cervix uteri during surgery. Real-time color and fluorescence videos and images were acquired using a custom-made multispectral fluorescence camera system.</p></sec><sec><title>Results</title><p>Real-time fluorescence lymphatic mapping was observed <italic>in vivo</italic> in six patients; a total of nine SLNs were detected, of which one (11%) contained metastases. <italic>Ex vivo</italic> fluorescence imaging revealed the remaining fluorescent signal in 11 of 197 non-sentinel LNs (5%), of which one contained metastatic tumor tissue. None of the non-fluorescent LNs contained metastases.</p></sec><sec><title>Conclusions</title><p>We conclude that lymphatic mapping and detection of the SLN in cervical cancer using intraoperative NIRF imaging is technically feasible. However, the technique needs to be refined for full applicability in cervical cancer in terms of sensitivity and specificity.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s11307-010-0425-7) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Loar, Pv" uniqKey="Loar P">PV Loar</name></author><author><name sortKey="Reynolds, Rk" uniqKey="Reynolds R">RK Reynolds</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name></author><author><name sortKey="Paganelli, G" uniqKey="Paganelli G">G Paganelli</name></author><author><name sortKey="Galimberti, V" uniqKey="Galimberti V">V Galimberti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL 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Soh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Ho" uniqKey="Smith H">HO Smith</name></author><author><name sortKey="Tiffany, Mf" uniqKey="Tiffany M">MF Tiffany</name></author><author><name sortKey="Qualls, Cr" uniqKey="Qualls C">CR Qualls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reimers, Ll" uniqKey="Reimers L">LL Reimers</name></author><author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name></author><author><name sortKey="Rosenberg, Ps" uniqKey="Rosenberg P">PS Rosenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamashita, T" uniqKey="Yamashita T">T Yamashita</name></author><author><name sortKey="Katayama, H" uniqKey="Katayama H">H Katayama</name></author><author><name sortKey="Kato, Y" uniqKey="Kato Y">Y Kato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frumovitz, M" uniqKey="Frumovitz M">M Frumovitz</name></author><author><name sortKey="Ramirez, Pt" uniqKey="Ramirez P">PT Ramirez</name></author><author><name sortKey="Levenback, Cf" uniqKey="Levenback C">CF Levenback</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lande, J" uniqKey="Lande J">J Lande</name></author><author><name sortKey="Torrenga, B" uniqKey="Torrenga B">B Torrenga</name></author><author><name sortKey="Raijmakers, Pg" uniqKey="Raijmakers P">PG Raijmakers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayhan, A" uniqKey="Ayhan A">A Ayhan</name></author><author><name sortKey="Celik, H" uniqKey="Celik H">H Celik</name></author><author><name sortKey="Dursun, P" uniqKey="Dursun P">P Dursun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cibula, D" uniqKey="Cibula D">D Cibula</name></author><author><name sortKey="Kuzel, D" uniqKey="Kuzel D">D Kuzel</name></author><author><name sortKey="Slama, J" uniqKey="Slama J">J Slama</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Groningue (province)</li></region><settlement><li>Groningue</li><li>Munich</li></settlement></list><tree><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Crane, Lucia M A" sort="Crane, Lucia M A" uniqKey="Crane L" first="Lucia M. A." last="Crane">Lucia M. A. Crane</name></region><name sortKey="Arts, Henriette J G" sort="Arts, Henriette J G" uniqKey="Arts H" first="Henriette J. G." last="Arts">Henriette J. G. Arts</name><name sortKey="Harlaar, Niels J" sort="Harlaar, Niels J" uniqKey="Harlaar N" first="Niels J." last="Harlaar">Niels J. Harlaar</name><name sortKey="Pleijhuis, Rick G" sort="Pleijhuis, Rick G" uniqKey="Pleijhuis R" first="Rick G." last="Pleijhuis">Rick G. Pleijhuis</name><name sortKey="Van Dam, Gooitzen M" sort="Van Dam, Gooitzen M" uniqKey="Van Dam G" first="Gooitzen M." last="Van Dam">Gooitzen M. Van Dam</name><name sortKey="Van Dam, Gooitzen M" sort="Van Dam, Gooitzen M" uniqKey="Van Dam G" first="Gooitzen M." last="Van Dam">Gooitzen M. Van Dam</name><name sortKey="Van Der Zee, Ate G J" sort="Van Der Zee, Ate G J" uniqKey="Van Der Zee A" first="Ate G. J." last="Van Der Zee">Ate G. J. Van Der Zee</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Themelis, George" sort="Themelis, George" uniqKey="Themelis G" first="George" last="Themelis">George Themelis</name></region><name sortKey="Harlaar, Niels J" sort="Harlaar, Niels J" uniqKey="Harlaar N" first="Niels J." last="Harlaar">Niels J. Harlaar</name><name sortKey="Sarantopoulos, Athanasios" sort="Sarantopoulos, Athanasios" uniqKey="Sarantopoulos A" first="Athanasios" last="Sarantopoulos">Athanasios Sarantopoulos</name><name sortKey="Vasilis, Ntziachristos" sort="Vasilis, Ntziachristos" uniqKey="Vasilis N" first="Ntziachristos" last="Vasilis">Ntziachristos Vasilis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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