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Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo.

Identifieur interne : 003141 ( Ncbi/Checkpoint ); précédent : 003140; suivant : 003142

Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo.

Auteurs : Claudius Conrad [États-Unis] ; Hanno Niess ; Ralf Huss ; Stephan Huber ; Irene Von Luettichau ; Peter J. Nelson ; Harald C. Ott ; Karl-Walter Jauch ; Christiane J. Bruns

Source :

RBID : pubmed:19118255

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Abstract

The importance and therapeutic value of stem cells in lymphangiogenesis are poorly understood. We evaluated the potential of human and murine mesenchymal stem cells (MSCs) to acquire a lymphatic phenotype in vitro and to enhance lymphatic regeneration in vivo.

DOI: 10.1161/CIRCULATIONAHA.108.793208
PubMed: 19118255


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pubmed:19118255

Le document en format XML

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<nlm:affiliation>Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. CConrad1@partners.org</nlm:affiliation>
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<name sortKey="Von Luettichau, Irene" sort="Von Luettichau, Irene" uniqKey="Von Luettichau I" first="Irene" last="Von Luettichau">Irene Von Luettichau</name>
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<name sortKey="Nelson, Peter J" sort="Nelson, Peter J" uniqKey="Nelson P" first="Peter J" last="Nelson">Peter J. Nelson</name>
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<name sortKey="Ott, Harald C" sort="Ott, Harald C" uniqKey="Ott H" first="Harald C" last="Ott">Harald C. Ott</name>
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<name sortKey="Jauch, Karl Walter" sort="Jauch, Karl Walter" uniqKey="Jauch K" first="Karl-Walter" last="Jauch">Karl-Walter Jauch</name>
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<term>Cell Movement (physiology)</term>
<term>Endothelium, Lymphatic (cytology)</term>
<term>Endothelium, Lymphatic (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphangiogenesis (physiology)</term>
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<term>Lymphatic Vessels (physiology)</term>
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<term>Mesenchymal Stromal Cells (physiology)</term>
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<term>Animaux</term>
<term>Cellules souches multipotentes (cytologie)</term>
<term>Cellules souches multipotentes (physiologie)</term>
<term>Cellules stromales mésenchymateuses (cytologie)</term>
<term>Cellules stromales mésenchymateuses (physiologie)</term>
<term>Différenciation cellulaire (physiologie)</term>
<term>Endothélium lymphatique (cytologie)</term>
<term>Endothélium lymphatique (physiologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Lymphangiogenèse (physiologie)</term>
<term>Mouvement cellulaire (physiologie)</term>
<term>Phénotype</term>
<term>Régénération (physiologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris de lignée C57BL</term>
<term>Vaisseaux lymphatiques (cytologie)</term>
<term>Vaisseaux lymphatiques (physiologie)</term>
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<term>Cellules souches multipotentes</term>
<term>Cellules stromales mésenchymateuses</term>
<term>Endothélium lymphatique</term>
<term>Vaisseaux lymphatiques</term>
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<term>Endothelium, Lymphatic</term>
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<term>Mesenchymal Stromal Cells</term>
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<term>Cellules stromales mésenchymateuses</term>
<term>Différenciation cellulaire</term>
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<term>Cell Differentiation</term>
<term>Cell Movement</term>
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<div type="abstract" xml:lang="en">The importance and therapeutic value of stem cells in lymphangiogenesis are poorly understood. We evaluated the potential of human and murine mesenchymal stem cells (MSCs) to acquire a lymphatic phenotype in vitro and to enhance lymphatic regeneration in vivo.</div>
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