Research perspectives in inherited lymphatic disease: an update.
Identifieur interne : 002D37 ( Ncbi/Checkpoint ); précédent : 002D36; suivant : 002D38Research perspectives in inherited lymphatic disease: an update.
Auteurs : Robert E. Ferrell [États-Unis] ; David N. FinegoldSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Facteurs de transcription Forkhead, Lymphoedème, Maladies lymphatiques, Syndrome de Noonan.
- tendances : Recherche.
- Animaux, Humains, Lymphangiogenèse.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Forkhead Transcription Factors.
- genetics : Lymphatic Diseases, Lymphedema, Noonan Syndrome.
- trends : Research.
- Animals, Humans, Lymphangiogenesis.
Abstract
Genetic studies of inherited lymphedema have provided the starting point for the molecular dissection of lymphatic development and disease. Here, we update the recent contribution of the study of inherited lymphedema and discuss the parallels between mouse models of lymphedema and inherited lymphedema. That the known mutations leading to lymphatic phenotypes explain fewer than half the cases of lymphedema means that the continued study of these disorders may reveal new pathways in lymphatic biology.
DOI: 10.1196/annals.1413.012
PubMed: 18519966
Affiliations:
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pubmed:18519966Le document en format XML
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<affiliation wicri:level="4"><nlm:affiliation>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA 15261, USA. rferrell@hgen.pitt.edu</nlm:affiliation>
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<front><div type="abstract" xml:lang="en">Genetic studies of inherited lymphedema have provided the starting point for the molecular dissection of lymphatic development and disease. Here, we update the recent contribution of the study of inherited lymphedema and discuss the parallels between mouse models of lymphedema and inherited lymphedema. That the known mutations leading to lymphatic phenotypes explain fewer than half the cases of lymphedema means that the continued study of these disorders may reveal new pathways in lymphatic biology.</div>
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