Animal models for the molecular and mechanistic study of lymphatic biology and disease.
Identifieur interne : 002D35 ( Ncbi/Checkpoint ); précédent : 002D34; suivant : 002D36Animal models for the molecular and mechanistic study of lymphatic biology and disease.
Auteurs : William S. Shin [États-Unis] ; Stanley G. RocksonSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type C (génétique), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Humains, Maladies lymphatiques (anatomopathologie), Modèles animaux de maladie humaine, Noeuds lymphatiques (anatomopathologie), Système lymphatique (anatomopathologie), Vaisseaux lymphatiques (anatomopathologie).
- MESH :
- anatomopathologie : Maladies lymphatiques, Noeuds lymphatiques, Système lymphatique, Vaisseaux lymphatiques.
- génétique : Facteur de croissance endothéliale vasculaire de type C.
- métabolisme : Facteur de croissance endothéliale vasculaire de type C.
- Animaux, Humains, Modèles animaux de maladie humaine.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor C.
- chemical , metabolism : Vascular Endothelial Growth Factor C.
- pathology : Lymph Nodes, Lymphatic Diseases, Lymphatic System, Lymphatic Vessels.
- Animals, Disease Models, Animal, Humans.
Abstract
The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.
DOI: 10.1196/annals.1413.005
PubMed: 18519959
Affiliations:
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Shin</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G" last="Rockson">Stanley G. Rockson</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Lymphatic Diseases (pathology)</term><term>Lymphatic System (pathology)</term><term>Lymphatic Vessels (pathology)</term><term>Vascular Endothelial Growth Factor C (genetics)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Humains</term><term>Maladies lymphatiques (anatomopathologie)</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Système lymphatique (anatomopathologie)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies lymphatiques</term><term>Noeuds lymphatiques</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term><term>Lymphatic Diseases</term><term>Lymphatic System</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Modèles animaux de maladie humaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G" last="Rockson">Stanley G. Rockson</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Shin, William S" sort="Shin, William S" uniqKey="Shin W" first="William S" last="Shin">William S. Shin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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