Lymphangiogenesis in myocardial remodelling after infarction
Identifieur interne : 002867 ( Ncbi/Checkpoint ); précédent : 002866; suivant : 002868Lymphangiogenesis in myocardial remodelling after infarction
Auteurs : Y. Ishikawa ; Y. Akishima-Fukasawa ; K. Ito ; Y. Akasaka ; M. Tanaka ; R. Shimokawa ; M. Kimura-Matsumoto ; H. Morita ; S. Sato ; I. Kamata ; T. IshiiSource :
- Histopathology [ 0309-0167 ] ; 2007.
Abstract
Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Tanaka M, Shimokawa R, Kimura-Matsumoto M, Morita H, Sato S, Kamata I & Ishii T (2007)
The lymphatic system is involved in fluid homeostasis of the cardiac interstitium, but lymphangiogenesis in myocardial remodelling has not previously been examined histopathologically. The aim was to investigate by D2-40 immunohistochemistry the sequential changes in lymphatic distribution in the process of myocardial remodelling after myocardial infarction (MI).
Myocardial tissues in various phases of healing after MI were obtained from 40 autopsied hearts. D2-40+ lymphatic vessel density (LD) and CD34+ blood vessel density (BD) in the lesion were determined. BD decreased with advance of myocardial necrosis, subsequently increased at the early stage of granulation and thereafter decreased with the progression of scar formation. In contrast, lymphatic vessels were not detected in lesions with coagulation necrosis, and newly formed lymphatics first appeared in the early stages of granulation. A subsequent increase in LD was demonstrated in the late stages of granulation, and lymphatics remained up to the scar phase. Vascular endothelial growth factor-C was consistently expressed in viable cardiomyocytes around the lesion in all of these stages.
In myocardial remodelling after MI, lymphangiogenesis lags behind blood vessel angiogenesis; newly formed lymphatics may be involved mainly in the maturation of fibrosis and scar formation through the drainage of excessive proteins and fluid.
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DOI: 10.1111/j.1365-2559.2007.02785.x
PubMed: 17727476
PubMed Central: 2366023
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Shimokawa</name></author><author><name sortKey="Kimura Matsumoto, M" sort="Kimura Matsumoto, M" uniqKey="Kimura Matsumoto M" first="M" last="Kimura-Matsumoto">M. Kimura-Matsumoto</name></author><author><name sortKey="Morita, H" sort="Morita, H" uniqKey="Morita H" first="H" last="Morita">H. Morita</name></author><author><name sortKey="Sato, S" sort="Sato, S" uniqKey="Sato S" first="S" last="Sato">S. Sato</name></author><author><name sortKey="Kamata, I" sort="Kamata, I" uniqKey="Kamata I" first="I" last="Kamata">I. Kamata</name></author><author><name sortKey="Ishii, T" sort="Ishii, T" uniqKey="Ishii T" first="T" last="Ishii">T. Ishii</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17727476</idno><idno type="pmc">2366023</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366023</idno><idno type="RBID">PMC:2366023</idno><idno type="doi">10.1111/j.1365-2559.2007.02785.x</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">002948</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002948</idno><idno type="wicri:Area/Pmc/Curation">002947</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002947</idno><idno type="wicri:Area/Pmc/Checkpoint">003B35</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003B35</idno><idno type="wicri:Area/Ncbi/Merge">002867</idno><idno type="wicri:Area/Ncbi/Curation">002867</idno><idno type="wicri:Area/Ncbi/Checkpoint">002867</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphangiogenesis in myocardial remodelling after infarction</title><author><name sortKey="Ishikawa, Y" sort="Ishikawa, Y" uniqKey="Ishikawa Y" first="Y" last="Ishikawa">Y. Ishikawa</name></author><author><name sortKey="Akishima Fukasawa, Y" sort="Akishima Fukasawa, Y" uniqKey="Akishima Fukasawa Y" first="Y" last="Akishima-Fukasawa">Y. Akishima-Fukasawa</name></author><author><name sortKey="Ito, K" sort="Ito, K" uniqKey="Ito K" first="K" last="Ito">K. Ito</name></author><author><name sortKey="Akasaka, Y" sort="Akasaka, Y" uniqKey="Akasaka Y" first="Y" last="Akasaka">Y. Akasaka</name></author><author><name sortKey="Tanaka, M" sort="Tanaka, M" uniqKey="Tanaka M" first="M" last="Tanaka">M. Tanaka</name></author><author><name sortKey="Shimokawa, R" sort="Shimokawa, R" uniqKey="Shimokawa R" first="R" last="Shimokawa">R. Shimokawa</name></author><author><name sortKey="Kimura Matsumoto, M" sort="Kimura Matsumoto, M" uniqKey="Kimura Matsumoto M" first="M" last="Kimura-Matsumoto">M. Kimura-Matsumoto</name></author><author><name sortKey="Morita, H" sort="Morita, H" uniqKey="Morita H" first="H" last="Morita">H. Morita</name></author><author><name sortKey="Sato, S" sort="Sato, S" uniqKey="Sato S" first="S" last="Sato">S. Sato</name></author><author><name sortKey="Kamata, I" sort="Kamata, I" uniqKey="Kamata I" first="I" last="Kamata">I. Kamata</name></author><author><name sortKey="Ishii, T" sort="Ishii, T" uniqKey="Ishii T" first="T" last="Ishii">T. Ishii</name></author></analytic><series><title level="j">Histopathology</title><idno type="ISSN">0309-0167</idno><idno type="eISSN">1365-2559</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Tanaka M, Shimokawa R, Kimura-Matsumoto M, Morita H, Sato S, Kamata I & Ishii T (2007) <italic>Histopathology</italic><bold>51,</bold> 345–353</p><p><bold>Lymphangiogenesis in myocardial remodelling after infarction</bold></p><sec><title>Aims</title><p>The lymphatic system is involved in fluid homeostasis of the cardiac interstitium, but lymphangiogenesis in myocardial remodelling has not previously been examined histopathologically. The aim was to investigate by D2-40 immunohistochemistry the sequential changes in lymphatic distribution in the process of myocardial remodelling after myocardial infarction (MI).</p></sec><sec sec-type="methods"><title>Methods and results</title><p>Myocardial tissues in various phases of healing after MI were obtained from 40 autopsied hearts. D2-40+ lymphatic vessel density (LD) and CD34+ blood vessel density (BD) in the lesion were determined. BD decreased with advance of myocardial necrosis, subsequently increased at the early stage of granulation and thereafter decreased with the progression of scar formation. In contrast, lymphatic vessels were not detected in lesions with coagulation necrosis, and newly formed lymphatics first appeared in the early stages of granulation. A subsequent increase in LD was demonstrated in the late stages of granulation, and lymphatics remained up to the scar phase. Vascular endothelial growth factor-C was consistently expressed in viable cardiomyocytes around the lesion in all of these stages.</p></sec><sec><title>Conclusion</title><p>In myocardial remodelling after MI, lymphangiogenesis lags behind blood vessel angiogenesis; newly formed lymphatics may be involved mainly in the maturation of fibrosis and scar formation through the drainage of excessive proteins and fluid.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Akasaka, Y" sort="Akasaka, Y" uniqKey="Akasaka Y" first="Y" last="Akasaka">Y. 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