Changes in Wuchereria bancrofti infection in a highly endemic community following 10 rounds of mass administration of diethylcarbamazine.
Identifieur interne : 002358 ( Ncbi/Checkpoint ); précédent : 002357; suivant : 002359Changes in Wuchereria bancrofti infection in a highly endemic community following 10 rounds of mass administration of diethylcarbamazine.
Auteurs : K D Ramaiah [Inde] ; P. Vanamail ; P K DasSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (sang), Calendrier d'administration des médicaments, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Femelle, Filaricides (administration et posologie), Filaricides (usage thérapeutique), Filariose lymphatique (), Filariose lymphatique (épidémiologie), Humains, Inde (épidémiologie), Maladies endémiques (), Mâle, Parasitémie (), Parasitémie (épidémiologie), Sujet âgé, Wuchereria bancrofti (immunologie), Wuchereria bancrofti (isolement et purification), Études transversales, Évaluation de médicament.
- MESH :
- administration et posologie : Diéthylcarbamazine, Filaricides.
- immunologie : Wuchereria bancrofti.
- isolement et purification : Wuchereria bancrofti.
- sang : Antigènes d'helminthe.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- épidémiologie : Filariose lymphatique, Inde, Parasitémie.
- Adulte, Adulte d'âge moyen, Animaux, Calendrier d'administration des médicaments, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Humains, Maladies endémiques, Mâle, Parasitémie, Sujet âgé, Études transversales, Évaluation de médicament.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adult, Aged, Animals, Antigens, Helminth (blood), Child, Child, Preschool, Cross-Sectional Studies, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (therapeutic use), Drug Administration Schedule, Drug Evaluation, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Endemic Diseases (prevention & control), Female, Filaricides (administration & dosage), Filaricides (therapeutic use), Humans, India (epidemiology), Male, Middle Aged, Parasitemia (epidemiology), Parasitemia (prevention & control), Wuchereria bancrofti (immunology), Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Filaricides.
- chemical , blood : Antigens, Helminth.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- geographic , epidemiology : India.
- epidemiology : Elephantiasis, Filarial, Parasitemia.
- immunology : Wuchereria bancrofti.
- isolation & purification : Wuchereria bancrofti.
- prevention & control : Elephantiasis, Filarial, Endemic Diseases, Parasitemia.
- Adult, Aged, Animals, Child, Child, Preschool, Cross-Sectional Studies, Drug Administration Schedule, Drug Evaluation, Female, Humans, Male, Middle Aged.
Abstract
Mass drug administration (MDA) is the principal strategy of the programme to eliminate lymphatic filariasis (LF). Evaluation of MDA in highly endemic 'sentinel' communities is necessary to understand its impact on LF infection. This study examined the changes in Wuchereria bancrofti infection following 10 rounds of annual mass administration of diethylcarbamazine (DEC) in a highly endemic community. The mean number of DEC treatments received per adult in the community was 7.4+/-2.0. Following 10 rounds of DEC administration, the number of microfilaria (mf) carriers fell from 565 to 55. None of the pre-MDA amicrofilaraemic individuals showed circulating filarial antigen (CFA). However, 54.5% of the pre-MDA microfilaraemic individuals were positive for CFA. All the pre-MDA high intensity mf carriers continued to be positive for CFA, and some of them also showed blood mf. These patients are the most difficult to be cured by MDA and were distributed in 8.2% of the households. All the children born during the last 7 years of the MDA programme were negative for CFA. The study suggests that six to seven DEC treatments per individual suppresses microfilaraemia, except in some people with heavy infection, and repeated MDA has very good potential to prevent infection in children.
DOI: 10.1016/j.trstmh.2006.05.007
PubMed: 16890256
Affiliations:
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Evaluation of MDA in highly endemic 'sentinel' communities is necessary to understand its impact on LF infection. This study examined the changes in Wuchereria bancrofti infection following 10 rounds of annual mass administration of diethylcarbamazine (DEC) in a highly endemic community. The mean number of DEC treatments received per adult in the community was 7.4+/-2.0. Following 10 rounds of DEC administration, the number of microfilaria (mf) carriers fell from 565 to 55. None of the pre-MDA amicrofilaraemic individuals showed circulating filarial antigen (CFA). However, 54.5% of the pre-MDA microfilaraemic individuals were positive for CFA. All the pre-MDA high intensity mf carriers continued to be positive for CFA, and some of them also showed blood mf. These patients are the most difficult to be cured by MDA and were distributed in 8.2% of the households. All the children born during the last 7 years of the MDA programme were negative for CFA. The study suggests that six to seven DEC treatments per individual suppresses microfilaraemia, except in some people with heavy infection, and repeated MDA has very good potential to prevent infection in children.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name><name sortKey="Vanamail, P" sort="Vanamail, P" uniqKey="Vanamail P" first="P" last="Vanamail">P. Vanamail</name></noCountry><country name="Inde"><noRegion><name sortKey="Ramaiah, K D" sort="Ramaiah, K D" uniqKey="Ramaiah K" first="K D" last="Ramaiah">K D Ramaiah</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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