[Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conservative surgery enhances late toxicities].
Identifieur interne : 002201 ( Ncbi/Checkpoint ); précédent : 002200; suivant : 002202[Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conservative surgery enhances late toxicities].
Auteurs : A. Toledano [France] ; P. Garaud ; D. Serin ; A. Fourquet ; J-F Bosset ; J. Miny-Buffet ; A. Favre ; D. Azria ; G. Body ; O. Le Floch ; G. CalaisSource :
- Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [ 1278-3218 ] ; 2006.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antinéoplasiques (administration et posologie), Antinéoplasiques alcoylants (administration et posologie), Atrophie, Cyclophosphamide (administration et posologie), Femelle, Fibrose, Fractionnement de la dose d'irradiation, Humains, Lymphadénectomie, Mastectomie partielle, Mitoxantrone (administration et posologie), Méthode en simple aveugle, Pigmentation de la peau (), Pigmentation de la peau (effets des radiations), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Radiothérapie adjuvante (effets indésirables), Région mammaire (), Région mammaire (effets des radiations), Sujet âgé, Traitement médicamenteux adjuvant (effets indésirables), Tumeurs du sein (), Tumeurs du sein (radiothérapie), Tumeurs du sein (traitement médicamenteux), Télangiectasie (), Télangiectasie (étiologie), Études de suivi, Études prospectives.
- MESH :
- administration et posologie : Antinéoplasiques, Antinéoplasiques alcoylants, Cyclophosphamide, Mitoxantrone.
- effets des radiations : Pigmentation de la peau, Région mammaire.
- effets indésirables : Radiothérapie adjuvante, Traitement médicamenteux adjuvant.
- radiothérapie : Tumeurs du sein.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- étiologie : Télangiectasie.
- Adulte, Adulte d'âge moyen, Atrophie, Femelle, Fibrose, Fractionnement de la dose d'irradiation, Humains, Lymphadénectomie, Mastectomie partielle, Méthode en simple aveugle, Pigmentation de la peau, Région mammaire, Sujet âgé, Tumeurs du sein, Télangiectasie, Études de suivi, Études prospectives.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Agents (administration & dosage), Antineoplastic Agents, Alkylating (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Atrophy, Breast (drug effects), Breast (radiation effects), Breast Neoplasms (drug therapy), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Chemotherapy, Adjuvant (adverse effects), Cyclophosphamide (administration & dosage), Dose Fractionation, Female, Fibrosis, Follow-Up Studies, Humans, Lymph Node Excision, Mastectomy, Segmental, Middle Aged, Mitoxantrone (administration & dosage), Prospective Studies, Radiotherapy, Adjuvant (adverse effects), Single-Blind Method, Skin Pigmentation (drug effects), Skin Pigmentation (radiation effects), Telangiectasis (chemically induced), Telangiectasis (etiology).
- MESH :
- chemical , administration & dosage : Antineoplastic Agents, Antineoplastic Agents, Alkylating, Cyclophosphamide, Mitoxantrone.
- adverse effects : Chemotherapy, Adjuvant, Radiotherapy, Adjuvant.
- chemically induced : Telangiectasis.
- drug effects : Breast, Skin Pigmentation.
- drug therapy : Breast Neoplasms.
- etiology : Telangiectasis.
- radiation effects : Breast, Skin Pigmentation.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Atrophy, Dose Fractionation, Female, Fibrosis, Follow-Up Studies, Humans, Lymph Node Excision, Mastectomy, Segmental, Middle Aged, Prospective Studies, Single-Blind Method.
Abstract
In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). Seven hundred sixteen patients were included in this trial. After a median follow-up of 6.7 (4.3-9) years, we decided to prospectively evaluate the late effects of these two strategies.
DOI: 10.1016/j.canrad.2006.03.001
PubMed: 16632399
Affiliations:
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pubmed:16632399Le document en format XML
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<term>Aged</term>
<term>Antineoplastic Agents (administration & dosage)</term>
<term>Antineoplastic Agents, Alkylating (administration & dosage)</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Atrophy</term>
<term>Breast (drug effects)</term>
<term>Breast (radiation effects)</term>
<term>Breast Neoplasms (drug therapy)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Breast Neoplasms (surgery)</term>
<term>Chemotherapy, Adjuvant (adverse effects)</term>
<term>Cyclophosphamide (administration & dosage)</term>
<term>Dose Fractionation</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lymph Node Excision</term>
<term>Mastectomy, Segmental</term>
<term>Middle Aged</term>
<term>Mitoxantrone (administration & dosage)</term>
<term>Prospective Studies</term>
<term>Radiotherapy, Adjuvant (adverse effects)</term>
<term>Single-Blind Method</term>
<term>Skin Pigmentation (drug effects)</term>
<term>Skin Pigmentation (radiation effects)</term>
<term>Telangiectasis (chemically induced)</term>
<term>Telangiectasis (etiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antinéoplasiques (administration et posologie)</term>
<term>Antinéoplasiques alcoylants (administration et posologie)</term>
<term>Atrophie</term>
<term>Cyclophosphamide (administration et posologie)</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Fractionnement de la dose d'irradiation</term>
<term>Humains</term>
<term>Lymphadénectomie</term>
<term>Mastectomie partielle</term>
<term>Mitoxantrone (administration et posologie)</term>
<term>Méthode en simple aveugle</term>
<term>Pigmentation de la peau ()</term>
<term>Pigmentation de la peau (effets des radiations)</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Radiothérapie adjuvante (effets indésirables)</term>
<term>Région mammaire ()</term>
<term>Région mammaire (effets des radiations)</term>
<term>Sujet âgé</term>
<term>Traitement médicamenteux adjuvant (effets indésirables)</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (radiothérapie)</term>
<term>Tumeurs du sein (traitement médicamenteux)</term>
<term>Télangiectasie ()</term>
<term>Télangiectasie (étiologie)</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Antineoplastic Agents, Alkylating</term>
<term>Cyclophosphamide</term>
<term>Mitoxantrone</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Antinéoplasiques alcoylants</term>
<term>Cyclophosphamide</term>
<term>Mitoxantrone</term>
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<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Chemotherapy, Adjuvant</term>
<term>Radiotherapy, Adjuvant</term>
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<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Telangiectasis</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Breast</term>
<term>Skin Pigmentation</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Pigmentation de la peau</term>
<term>Région mammaire</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Radiothérapie adjuvante</term>
<term>Traitement médicamenteux adjuvant</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Telangiectasis</term>
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<term>Skin Pigmentation</term>
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<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
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<term>Aged</term>
<term>Atrophy</term>
<term>Dose Fractionation</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lymph Node Excision</term>
<term>Mastectomy, Segmental</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Single-Blind Method</term>
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<term>Adulte d'âge moyen</term>
<term>Atrophie</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Fractionnement de la dose d'irradiation</term>
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<term>Lymphadénectomie</term>
<term>Mastectomie partielle</term>
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<term>Sujet âgé</term>
<term>Tumeurs du sein</term>
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<front><div type="abstract" xml:lang="en">In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). Seven hundred sixteen patients were included in this trial. After a median follow-up of 6.7 (4.3-9) years, we decided to prospectively evaluate the late effects of these two strategies.</div>
</front>
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<affiliations><list><country><li>France</li>
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<region><li>Île-de-France</li>
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<settlement><li>Paris</li>
</settlement>
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<tree><noCountry><name sortKey="Azria, D" sort="Azria, D" uniqKey="Azria D" first="D" last="Azria">D. Azria</name>
<name sortKey="Body, G" sort="Body, G" uniqKey="Body G" first="G" last="Body">G. Body</name>
<name sortKey="Bosset, J F" sort="Bosset, J F" uniqKey="Bosset J" first="J-F" last="Bosset">J-F Bosset</name>
<name sortKey="Calais, G" sort="Calais, G" uniqKey="Calais G" first="G" last="Calais">G. Calais</name>
<name sortKey="Favre, A" sort="Favre, A" uniqKey="Favre A" first="A" last="Favre">A. Favre</name>
<name sortKey="Fourquet, A" sort="Fourquet, A" uniqKey="Fourquet A" first="A" last="Fourquet">A. Fourquet</name>
<name sortKey="Garaud, P" sort="Garaud, P" uniqKey="Garaud P" first="P" last="Garaud">P. Garaud</name>
<name sortKey="Le Floch, O" sort="Le Floch, O" uniqKey="Le Floch O" first="O" last="Le Floch">O. Le Floch</name>
<name sortKey="Miny Buffet, J" sort="Miny Buffet, J" uniqKey="Miny Buffet J" first="J" last="Miny-Buffet">J. Miny-Buffet</name>
<name sortKey="Serin, D" sort="Serin, D" uniqKey="Serin D" first="D" last="Serin">D. Serin</name>
</noCountry>
<country name="France"><region name="Île-de-France"><name sortKey="Toledano, A" sort="Toledano, A" uniqKey="Toledano A" first="A" last="Toledano">A. Toledano</name>
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