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Dose-dependent response of FGF-2 for lymphangiogenesis

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Dose-dependent response of FGF-2 for lymphangiogenesis

Auteurs : Lynn K. Chang ; Guillermo Garcia-Carde A ; Filip Farnebo [États-Unis] ; Michael Fannon ; Emy J. Chen ; Catherine Butterfield ; Marsha A. Moses ; Richard C. Mulligan [États-Unis] ; Judah Folkman ; Arja Kaipainen

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2004.

RBID : PMC:511009

Abstract

Spatio-temporal studies on the growth of capillary blood vessels and capillary lymphatic vessels in tissue remodeling have suggested that lymphangiogenesis is angiogenesis-dependent. We revisited this concept by using fibroblast growth factor 2 (FGF-2) (80 ng) to stimulate the growth of both vessel types in the mouse cornea. When we lowered the dose of FGF-2 in the cornea 6.4-fold (12.5 ng), the primary response was lymphangiogenic. Further investigation revealed that vascular endothelial growth factor-C and -D are required for this apparent lymphangiogenic property of FGF-2, and when the small amount of accompanying angiogenesis was completely suppressed, lymphangiogenesis remained unaffected. Our findings demonstrate that there is a dose-dependent response of FGF-2 for lymphangiogenesis, and lymphangiogenesis can occur in the absence of a preexisting or developing vascular bed, i.e., in the absence of angiogenesis, in the mouse cornea.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC511009

DOI: 10.1073/pnas.0404272101
PubMed: 15289610
PubMed Central: 511009

Affiliations:

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PMC:511009

Le document en format XML

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<author><name sortKey="Garcia Carde A, Guillermo" sort="Garcia Carde A, Guillermo" uniqKey="Garcia Carde A G" first="Guillermo" last="Garcia-Carde A">Guillermo Garcia-Carde A</name>
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<front><div type="abstract" xml:lang="en"><p>Spatio-temporal studies on the growth of capillary blood vessels and capillary lymphatic vessels in tissue remodeling have suggested that lymphangiogenesis is angiogenesis-dependent. We revisited this concept by using fibroblast growth factor 2 (FGF-2) (80 ng) to stimulate the growth of both vessel types in the mouse cornea. When we lowered the dose of FGF-2 in the cornea 6.4-fold (12.5 ng), the primary response was lymphangiogenic. Further investigation revealed that vascular endothelial growth factor-C and -D are required for this apparent lymphangiogenic property of FGF-2, and when the small amount of accompanying angiogenesis was completely suppressed, lymphangiogenesis remained unaffected. Our findings demonstrate that there is a dose-dependent response of FGF-2 for lymphangiogenesis, and lymphangiogenesis can occur in the absence of a preexisting or developing vascular bed, i.e., in the absence of angiogenesis, in the mouse cornea.</p>
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<name sortKey="Fannon, Michael" sort="Fannon, Michael" uniqKey="Fannon M" first="Michael" last="Fannon">Michael Fannon</name>
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Dose-dependent response of FGF-2 for lymphangiogenesis

Dose-dependent response of FGF-2 for lymphangiogenesis

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