Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis.
Identifieur interne : 001715 ( Ncbi/Checkpoint ); précédent : 001714; suivant : 001716Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis.
Auteurs : A G Hise [États-Unis] ; F E Hazlett ; M J Bockarie ; P A Zimmerman ; D J Tisch ; J W KazuraSource :
- Genes and immunity [ 1466-4879 ] ; 2003.
Descripteurs français
- KwdFr :
- Animaux, Antigènes d'helminthe (sang), Filariose lymphatique (génétique), Filariose lymphatique (immunologie), Fréquence d'allèle, Humains, Immunité innée, Microfilaria (immunologie), Microfilaria (isolement et purification), Polymorphisme génétique (génétique), Polymorphisme génétique (immunologie), Prédisposition génétique à une maladie, Wuchereria bancrofti (immunologie), Wuchereria bancrofti (isolement et purification).
- MESH :
- génétique : Filariose lymphatique, Polymorphisme génétique.
- immunologie : Filariose lymphatique, Microfilaria, Polymorphisme génétique, Wuchereria bancrofti.
- isolement et purification : Microfilaria, Wuchereria bancrofti.
- sang : Antigènes d'helminthe.
- Animaux, Fréquence d'allèle, Humains, Immunité innée, Prédisposition génétique à une maladie.
English descriptors
- KwdEn :
- Animals, Antigens, Helminth (blood), Elephantiasis, Filarial (genetics), Elephantiasis, Filarial (immunology), Gene Frequency, Genetic Predisposition to Disease, Humans, Immunity, Innate, Microfilariae (immunology), Microfilariae (isolation & purification), Polymorphism, Genetic (genetics), Polymorphism, Genetic (immunology), Wuchereria bancrofti (immunology), Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , blood : Antigens, Helminth.
- genetics : Elephantiasis, Filarial, Polymorphism, Genetic.
- immunology : Elephantiasis, Filarial, Microfilariae, Polymorphism, Genetic, Wuchereria bancrofti.
- isolation & purification : Microfilariae, Wuchereria bancrofti.
- Animals, Gene Frequency, Genetic Predisposition to Disease, Humans, Immunity, Innate.
Abstract
We examined 906 residents of an area of Papua New Guinea where bancroftian filariasis is endemic for genetic polymorphisms in three innate immunity genes suspected of contributing to susceptibility to infection and lymphatic pathology. Active infection was confirmed by the presence of blood-borne microfilariae and circulating filarial antigen in plasma. Disease was ascertained by physical examination for the presence of overt lymphedema (severe swelling of an arm or leg) or hydrocele. There was no association of infection status, lymphedema of an extremity, or hydrocele with chitotriosidase genotype (CHIT1). Polymorphisms of toll-like receptor-2 and toll-like receptor-4 genes (TLR4 A896G; TLR2 T2178A, G2258A) were not detected (N=200-625 individuals genotyped) except for two individuals heterozygous for a TLR2 mutation (C2029 T). These results indicate that a CHIT1 genotype associated previously with susceptibility to filariasis in residents of southern India and TLR2 and TLR4 polymorphisms do not correlate with infection status or disease phenotype in this Melanesian population.
DOI: 10.1038/sj.gene.6364015
PubMed: 14551607
Affiliations:
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Disease</term><term>Humans</term><term>Immunity, Innate</term><term>Microfilariae (immunology)</term><term>Microfilariae (isolation & purification)</term><term>Polymorphism, Genetic (genetics)</term><term>Polymorphism, Genetic (immunology)</term><term>Wuchereria bancrofti (immunology)</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes d'helminthe (sang)</term><term>Filariose lymphatique (génétique)</term><term>Filariose lymphatique (immunologie)</term><term>Fréquence d'allèle</term><term>Humains</term><term>Immunité innée</term><term>Microfilaria (immunologie)</term><term>Microfilaria (isolement et purification)</term><term>Polymorphisme génétique (génétique)</term><term>Polymorphisme génétique (immunologie)</term><term>Prédisposition génétique à une maladie</term><term>Wuchereria bancrofti (immunologie)</term><term>Wuchereria bancrofti (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Filariose lymphatique</term><term>Polymorphisme génétique</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Microfilaria</term><term>Polymorphisme génétique</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Microfilariae</term><term>Polymorphism, Genetic</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Microfilaria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Immunity, Innate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Fréquence d'allèle</term><term>Humains</term><term>Immunité innée</term><term>Prédisposition génétique à une maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined 906 residents of an area of Papua New Guinea where bancroftian filariasis is endemic for genetic polymorphisms in three innate immunity genes suspected of contributing to susceptibility to infection and lymphatic pathology. Active infection was confirmed by the presence of blood-borne microfilariae and circulating filarial antigen in plasma. Disease was ascertained by physical examination for the presence of overt lymphedema (severe swelling of an arm or leg) or hydrocele. There was no association of infection status, lymphedema of an extremity, or hydrocele with chitotriosidase genotype (CHIT1). Polymorphisms of toll-like receptor-2 and toll-like receptor-4 genes (TLR4 A896G; TLR2 T2178A, G2258A) were not detected (N=200-625 individuals genotyped) except for two individuals heterozygous for a TLR2 mutation (C2029 T). These results indicate that a CHIT1 genotype associated previously with susceptibility to filariasis in residents of southern India and TLR2 and TLR4 polymorphisms do not correlate with infection status or disease phenotype in this Melanesian population.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><noCountry><name sortKey="Bockarie, M J" sort="Bockarie, M J" uniqKey="Bockarie M" first="M J" last="Bockarie">M J Bockarie</name><name sortKey="Hazlett, F E" sort="Hazlett, F E" uniqKey="Hazlett F" first="F E" last="Hazlett">F E Hazlett</name><name sortKey="Kazura, J W" sort="Kazura, J W" uniqKey="Kazura J" first="J W" last="Kazura">J W Kazura</name><name sortKey="Tisch, D J" sort="Tisch, D J" uniqKey="Tisch D" first="D J" last="Tisch">D J Tisch</name><name sortKey="Zimmerman, P A" sort="Zimmerman, P A" uniqKey="Zimmerman P" first="P A" last="Zimmerman">P A Zimmerman</name></noCountry><country name="États-Unis"><region name="Ohio"><name sortKey="Hise, A G" sort="Hise, A G" uniqKey="Hise A" first="A G" last="Hise">A G Hise</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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