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Prostaglandins, rheumatoid arthritis, fibrin and lymphoedema.

Identifieur interne : 000743 ( Ncbi/Checkpoint ); précédent : 000742; suivant : 000744

Prostaglandins, rheumatoid arthritis, fibrin and lymphoedema.

Auteurs : M K Jasani ; C S Bach

Source :

RBID : pubmed:115258

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English descriptors

Abstract

Rheumatoid joint swelling is in part due to lymphoedema accompanying extravascular (E-V) deposition of fibrin. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin (ASA), phenylbutazone (PBZ) and indomethacin (INDO) which share the ability to inhibit prostaglandin synthetase fail to prevent fibrinous lymphoedema occurring in rabbit skin homografts in association with the presence of sensitised lymphocytes. The data highlight the need to define whether or not prostaglandins promote lymphocytic fibrinous lymphoedema.

PubMed: 115258


Affiliations:


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pubmed:115258

Le document en format XML

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<author>
<name sortKey="Bach, C S" sort="Bach, C S" uniqKey="Bach C" first="C S" last="Bach">C S Bach</name>
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<title xml:lang="en">Prostaglandins, rheumatoid arthritis, fibrin and lymphoedema.</title>
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<name sortKey="Jasani, M K" sort="Jasani, M K" uniqKey="Jasani M" first="M K" last="Jasani">M K Jasani</name>
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<name sortKey="Bach, C S" sort="Bach, C S" uniqKey="Bach C" first="C S" last="Bach">C S Bach</name>
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<title level="j">Agents and actions. Supplements</title>
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<term>Animals</term>
<term>Anti-Inflammatory Agents (pharmacology)</term>
<term>Arthritis, Rheumatoid (physiopathology)</term>
<term>Cyclooxygenase Inhibitors</term>
<term>Fibrin (physiology)</term>
<term>Indomethacin (pharmacology)</term>
<term>Lymphedema (physiopathology)</term>
<term>Lymphocytes (drug effects)</term>
<term>Lymphocytes (physiology)</term>
<term>Prostaglandins (physiology)</term>
<term>Rabbits</term>
<term>Skin Transplantation</term>
<term>Transplantation, Homologous</term>
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<term>Animaux</term>
<term>Anti-inflammatoires (pharmacologie)</term>
<term>Fibrine (physiologie)</term>
<term>Indométacine (pharmacologie)</term>
<term>Inhibiteurs des cyclooxygénases</term>
<term>Lapins</term>
<term>Lymphocytes ()</term>
<term>Lymphocytes (physiologie)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Polyarthrite rhumatoïde (physiopathologie)</term>
<term>Prostaglandines (physiologie)</term>
<term>Transplantation de peau</term>
<term>Transplantation homologue</term>
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<term>Anti-Inflammatory Agents</term>
<term>Indomethacin</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en">
<term>Fibrin</term>
<term>Prostaglandins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Lymphocytes</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Anti-inflammatoires</term>
<term>Indométacine</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Fibrine</term>
<term>Lymphocytes</term>
<term>Prostaglandines</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Lymphoedème</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Arthritis, Rheumatoid</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Cyclooxygenase Inhibitors</term>
<term>Rabbits</term>
<term>Skin Transplantation</term>
<term>Transplantation, Homologous</term>
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<term>Animaux</term>
<term>Inhibiteurs des cyclooxygénases</term>
<term>Lapins</term>
<term>Lymphocytes</term>
<term>Transplantation de peau</term>
<term>Transplantation homologue</term>
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<div type="abstract" xml:lang="en">Rheumatoid joint swelling is in part due to lymphoedema accompanying extravascular (E-V) deposition of fibrin. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin (ASA), phenylbutazone (PBZ) and indomethacin (INDO) which share the ability to inhibit prostaglandin synthetase fail to prevent fibrinous lymphoedema occurring in rabbit skin homografts in association with the presence of sensitised lymphocytes. The data highlight the need to define whether or not prostaglandins promote lymphocytic fibrinous lymphoedema.</div>
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