Tolerance to diethylcarbamazine-medicated salt in individuals infected with Onchocerca volvulus.
Identifieur interne : 000507 ( Ncbi/Checkpoint ); précédent : 000506; suivant : 000508Tolerance to diethylcarbamazine-medicated salt in individuals infected with Onchocerca volvulus.
Auteurs : D W Meyrowitsch [Danemark] ; P E Simonsen ; P. MagnussenSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]
Descripteurs français
- KwdFr :
- Adulte, Animaux, Chlorure de sodium alimentaire, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (effets indésirables), Filaricides (administration et posologie), Filaricides (effets indésirables), Filariose lymphatique (), Humains, Mâle, Méthode en double aveugle, Onchocerca volvulus, Onchocercose (), Onchocercose (traitement médicamenteux), Prurit (), Toxidermies (étiologie).
- MESH :
- administration et posologie : Diéthylcarbamazine, Filaricides.
- effets indésirables : Diéthylcarbamazine, Filaricides.
- traitement médicamenteux : Onchocercose.
- étiologie : Toxidermies.
- Adulte, Animaux, Chlorure de sodium alimentaire, Filariose lymphatique, Humains, Mâle, Méthode en double aveugle, Onchocerca volvulus, Onchocercose, Prurit.
English descriptors
- KwdEn :
- Adult, Animals, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (adverse effects), Double-Blind Method, Drug Eruptions (etiology), Elephantiasis, Filarial (complications), Filaricides (administration & dosage), Filaricides (adverse effects), Humans, Male, Onchocerca volvulus, Onchocerciasis (complications), Onchocerciasis (drug therapy), Pruritus (chemically induced), Sodium Chloride, Dietary.
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Filaricides.
- chemical , adverse effects : Diethylcarbamazine, Filaricides.
- chemically induced : Pruritus.
- complications : Elephantiasis, Filarial, Onchocerciasis.
- drug therapy : Onchocerciasis.
- etiology : Drug Eruptions.
- Adult, Animals, Double-Blind Method, Humans, Male, Onchocerca volvulus, Sodium Chloride, Dietary.
Abstract
The tolerance of Onchocerca volvulus-infected individuals to diethylcarbamazine (DEC)-medicated salt (0.33% w/w) was assessed in 1996 in Tanzania in a double-blind placebo-controlled hospital-based trial involving 4 groups, each of 10 adult males. Groups I and II had O. volvulus microfilariae (mf) only, group III had both O. volvulus and Wuchereria bancrofti mf, and group IV had W. bancrofti mf only. Groups I, III and IV received DEC-medicated salt, whereas group II was a control to group I and received normal cooking salt. Medication was given for 10 days. The most pronounced adverse reactions in groups I and III were mild-to-moderate itching and rash, beginning after 3-4 days and lasting for the remaining medication period. The reactions did not interfere with normal daily activities. By 20 days after the end of medication, adverse reactions had disappeared in all individuals. The low daily dose of DEC had no significant effect on the O. volvulus pre-medication mf geometric mean intensities (GMIs). In contrast, the medication significantly reduced the pre-medication W. bancrofti mf GMIs. The prospects for using DEC-medicated salt for control of bancroftian filariasis in areas where incidental infections with O. volvulus occur are discussed.
PubMed: 11127254
Affiliations:
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Groups I and II had O. volvulus microfilariae (mf) only, group III had both O. volvulus and Wuchereria bancrofti mf, and group IV had W. bancrofti mf only. Groups I, III and IV received DEC-medicated salt, whereas group II was a control to group I and received normal cooking salt. Medication was given for 10 days. The most pronounced adverse reactions in groups I and III were mild-to-moderate itching and rash, beginning after 3-4 days and lasting for the remaining medication period. The reactions did not interfere with normal daily activities. By 20 days after the end of medication, adverse reactions had disappeared in all individuals. The low daily dose of DEC had no significant effect on the O. volvulus pre-medication mf geometric mean intensities (GMIs). In contrast, the medication significantly reduced the pre-medication W. bancrofti mf GMIs. The prospects for using DEC-medicated salt for control of bancroftian filariasis in areas where incidental infections with O. volvulus occur are discussed.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><noCountry><name sortKey="Magnussen, P" sort="Magnussen, P" uniqKey="Magnussen P" first="P" last="Magnussen">P. Magnussen</name><name sortKey="Simonsen, P E" sort="Simonsen, P E" uniqKey="Simonsen P" first="P E" last="Simonsen">P E Simonsen</name></noCountry><country name="Danemark"><noRegion><name sortKey="Meyrowitsch, D W" sort="Meyrowitsch, D W" uniqKey="Meyrowitsch D" first="D W" last="Meyrowitsch">D W Meyrowitsch</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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