Intralymphatic antibiotic delivery for reducing acute prosthetic graft infection.
Identifieur interne : 013E94 ( Main/Merge ); précédent : 013E93; suivant : 013E95Intralymphatic antibiotic delivery for reducing acute prosthetic graft infection.
Auteurs : D L Folsom [États-Unis] ; D. Franceschi ; J R RubinSource :
- The Journal of cardiovascular surgery [ 0021-9509 ]
Descripteurs français
- KwdFr :
- Animaux, Attribution aléatoire, Bactériémie (), Chiens, Humains, Infections dues aux prothèses (), Infections à staphylocoques (), Injections lymphatiques, Perfusions veineuses, Polytétrafluoroéthylène, Prothèse vasculaire (effets indésirables), Staphylococcus epidermidis, Vancomycine (administration et posologie), Vancomycine (usage thérapeutique).
- MESH :
- administration et posologie : Vancomycine.
- effets indésirables : Prothèse vasculaire.
- usage thérapeutique : Vancomycine.
- Animaux, Attribution aléatoire, Bactériémie, Chiens, Humains, Infections dues aux prothèses, Infections à staphylocoques, Injections lymphatiques, Perfusions veineuses, Polytétrafluoroéthylène, Staphylococcus epidermidis.
English descriptors
- KwdEn :
- Animals, Bacteremia (prevention & control), Blood Vessel Prosthesis (adverse effects), Dogs, Humans, Infusions, Intravenous, Injections, Intralymphatic, Polytetrafluoroethylene, Prosthesis-Related Infections (prevention & control), Random Allocation, Staphylococcal Infections (prevention & control), Staphylococcus epidermidis, Vancomycin (administration & dosage), Vancomycin (therapeutic use).
- MESH :
- chemical , administration & dosage : Vancomycin.
- chemical , therapeutic use : Vancomycin.
- chemical : Polytetrafluoroethylene.
- adverse effects : Blood Vessel Prosthesis.
- prevention & control : Bacteremia, Prosthesis-Related Infections, Staphylococcal Infections.
- Animals, Dogs, Humans, Infusions, Intravenous, Injections, Intralymphatic, Random Allocation, Staphylococcus epidermidis.
Abstract
The lymphatic system has been implicated as a source of synthetic graft contamination when grafts are implanted in the presence of a distal septic focus. In previous studies, radical lymphatic excision and ligation were shown to reduce acute graft sepsis. However significant lymphedema precluded its clinical application. The present study was undertaken to evaluate methods for reducing acute graft sepsis while avoiding lymphatic obstructive complications. Twenty dogs were divided into one control and two experimental cohorts. Femoral interposition grafts were placed in each dog. A hind paw septic focus was introduced and therapy included a control (Group I--no therapy), intravenous antibiotics in Group II and intralymphatic antibiotics in Group III. Graft, blood and tissue cultures from each dog were taken at 48 hours. Lymphatic antibiotic therapy resulted in significantly improved graft culture results when compared to the control (p = 0.0003) and intravenously treated animals (p = 0.007). Blood cultures in the intralymphatically treated group were also significantly better (p = 0.003) than the control group.
PubMed: 1287002
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pubmed:1287002Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intralymphatic antibiotic delivery for reducing acute prosthetic graft infection.</title><author><name sortKey="Folsom, D L" sort="Folsom, D L" uniqKey="Folsom D" first="D L" last="Folsom">D L Folsom</name><affiliation wicri:level="2"><nlm:affiliation>School of Medicine, Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>School of Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Franceschi, D" sort="Franceschi, D" uniqKey="Franceschi D" first="D" last="Franceschi">D. Franceschi</name></author><author><name sortKey="Rubin, J R" sort="Rubin, J R" uniqKey="Rubin J" first="J R" last="Rubin">J R Rubin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1992 Nov-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:1287002</idno><idno type="pmid">1287002</idno><idno type="wicri:Area/PubMed/Corpus">005862</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005862</idno><idno type="wicri:Area/PubMed/Curation">005862</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005862</idno><idno type="wicri:Area/PubMed/Checkpoint">005862</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005862</idno><idno type="wicri:Area/Ncbi/Merge">000E11</idno><idno type="wicri:Area/Ncbi/Curation">000E11</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E11</idno><idno type="wicri:doubleKey">0021-9509::Folsom D:intralymphatic:antibiotic:delivery</idno><idno type="wicri:Area/Main/Merge">013E94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Intralymphatic antibiotic delivery for reducing acute prosthetic graft infection.</title><author><name sortKey="Folsom, D L" sort="Folsom, D L" uniqKey="Folsom D" first="D L" last="Folsom">D L Folsom</name><affiliation wicri:level="2"><nlm:affiliation>School of Medicine, Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>School of Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Franceschi, D" sort="Franceschi, D" uniqKey="Franceschi D" first="D" last="Franceschi">D. Franceschi</name></author><author><name sortKey="Rubin, J R" sort="Rubin, J R" uniqKey="Rubin J" first="J R" last="Rubin">J R Rubin</name></author></analytic><series><title level="j">The Journal of cardiovascular surgery</title><idno type="ISSN">0021-9509</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bacteremia (prevention & control)</term><term>Blood Vessel Prosthesis (adverse effects)</term><term>Dogs</term><term>Humans</term><term>Infusions, Intravenous</term><term>Injections, Intralymphatic</term><term>Polytetrafluoroethylene</term><term>Prosthesis-Related Infections (prevention & control)</term><term>Random Allocation</term><term>Staphylococcal Infections (prevention & control)</term><term>Staphylococcus epidermidis</term><term>Vancomycin (administration & dosage)</term><term>Vancomycin (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Bactériémie ()</term><term>Chiens</term><term>Humains</term><term>Infections dues aux prothèses ()</term><term>Infections à staphylocoques ()</term><term>Injections lymphatiques</term><term>Perfusions veineuses</term><term>Polytétrafluoroéthylène</term><term>Prothèse vasculaire (effets indésirables)</term><term>Staphylococcus epidermidis</term><term>Vancomycine (administration et posologie)</term><term>Vancomycine (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vancomycin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Vancomycin</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Polytetrafluoroethylene</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vancomycine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Blood Vessel Prosthesis</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Prothèse vasculaire</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Bacteremia</term><term>Prosthesis-Related Infections</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vancomycine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Humans</term><term>Infusions, Intravenous</term><term>Injections, Intralymphatic</term><term>Random Allocation</term><term>Staphylococcus epidermidis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Bactériémie</term><term>Chiens</term><term>Humains</term><term>Infections dues aux prothèses</term><term>Infections à staphylocoques</term><term>Injections lymphatiques</term><term>Perfusions veineuses</term><term>Polytétrafluoroéthylène</term><term>Staphylococcus epidermidis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic system has been implicated as a source of synthetic graft contamination when grafts are implanted in the presence of a distal septic focus. In previous studies, radical lymphatic excision and ligation were shown to reduce acute graft sepsis. However significant lymphedema precluded its clinical application. The present study was undertaken to evaluate methods for reducing acute graft sepsis while avoiding lymphatic obstructive complications. Twenty dogs were divided into one control and two experimental cohorts. Femoral interposition grafts were placed in each dog. A hind paw septic focus was introduced and therapy included a control (Group I--no therapy), intravenous antibiotics in Group II and intralymphatic antibiotics in Group III. Graft, blood and tissue cultures from each dog were taken at 48 hours. Lymphatic antibiotic therapy resulted in significantly improved graft culture results when compared to the control (p = 0.0003) and intravenously treated animals (p = 0.007). Blood cultures in the intralymphatically treated group were also significantly better (p = 0.003) than the control group.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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