Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome
Identifieur interne : 00E314 ( Main/Merge ); précédent : 00E313; suivant : 00E315Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome
Auteurs : Lars Gunnar Kindblom [Suède] ; Göran Stenman [Suède] ; Lennart Angervall [Suède]Source :
- Virchows Archiv A [ 0174-7398 ] ; 1991-09-01.
Abstract
Summary: A morphological and cytogenetic analysis of a multifocal angiosarcoma in a typical case of Stewart-Treves syndrome is reported. The morphological analysis indicated differentiation along both blood and lymph vessel endothelium lines. By light and electron microscopy there were areas with well-developed erythrocyte-containing, capillary-like vessels and poorly differentiated areas with abortive vascular formations. In these the endothelium revealed immunoreactivity to factor VIII RAg, binding ofUlex europaeus I andPsophocarpus tetragonolobus agglutinin lectins, Weibel-Palade bodies ultrastructurally and presented a continuous enclosing external lamina and immunoreactivity for laminin and collagen IV, all features of blood-vessel differentiation. There were also lymphangioma-like areas as well as poorly differentiated areas where the immunohistochemical, lectin-binding and ultrastructural features were compatible with a lymph vessel differentiation. Cytogenetic analysis of cultured tumour cells revealed chromosome counts in the diploid region. About 40% of the cells analysed had a normal diploid karyotype. The remaining cells showed a multitude of mainly nonclonal structural alterations; 17 unique marker types resulting from different translocations and deletions were observed. There were also a few cells with clonal numerical deviations showing monosomy 22, monosomy X and trisomy 2 respectively. It is of interest that the losses of chromosome 22 and the X chromosome also have been observed in Kaposi's sarcoma and that the PD-ECGF gene, a novel angiogenetic factor, has been mapped to chromosome 22.
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DOI: 10.1007/BF01605079
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome</title><author><name sortKey="Kindblom, Lars Gunnar" sort="Kindblom, Lars Gunnar" uniqKey="Kindblom L" first="Lars Gunnar" last="Kindblom">Lars Gunnar Kindblom</name></author><author><name sortKey="Stenman, Goran" sort="Stenman, Goran" uniqKey="Stenman G" first="Göran" last="Stenman">Göran Stenman</name></author><author><name sortKey="Angervall, Lennart" sort="Angervall, Lennart" uniqKey="Angervall L" first="Lennart" last="Angervall">Lennart Angervall</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7EA3B3D69863EBE26C06769132F6E05CFCE03690</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1007/BF01605079</idno><idno type="url">https://api.istex.fr/document/7EA3B3D69863EBE26C06769132F6E05CFCE03690/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003B55</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003B55</idno><idno type="wicri:Area/Istex/Curation">003B55</idno><idno type="wicri:Area/Istex/Checkpoint">005339</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">005339</idno><idno type="wicri:doubleKey">0174-7398:1991:Kindblom L:morphological:and:cytogenetic</idno><idno type="wicri:Area/Main/Merge">00E314</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome</title><author><name sortKey="Kindblom, Lars Gunnar" sort="Kindblom, Lars Gunnar" uniqKey="Kindblom L" first="Lars Gunnar" last="Kindblom">Lars Gunnar Kindblom</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Departments of Pathology and Laboratory of Cytogenetics, Department of Oral Pathology, University of Göteborg, S-41345, Göteborg</wicri:regionArea><wicri:noRegion>Göteborg</wicri:noRegion></affiliation></author><author><name sortKey="Stenman, Goran" sort="Stenman, Goran" uniqKey="Stenman G" first="Göran" last="Stenman">Göran Stenman</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Departments of Pathology and Laboratory of Cytogenetics, Department of Oral Pathology, University of Göteborg, S-41345, Göteborg</wicri:regionArea><wicri:noRegion>Göteborg</wicri:noRegion></affiliation></author><author><name sortKey="Angervall, Lennart" sort="Angervall, Lennart" uniqKey="Angervall L" first="Lennart" last="Angervall">Lennart Angervall</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Departments of Pathology and Laboratory of Cytogenetics, Department of Oral Pathology, University of Göteborg, S-41345, Göteborg</wicri:regionArea><wicri:noRegion>Göteborg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virchows Archiv A</title><title level="j" type="sub">Pathological Anatomy and Histopathology</title><title level="j" type="abbrev">Vichows Archiv A Pathol Anat</title><idno type="ISSN">0174-7398</idno><idno type="eISSN">1432-2307</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-09-01">1991-09-01</date><biblScope unit="volume">419</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="439">439</biblScope><biblScope unit="page" to="445">445</biblScope></imprint><idno type="ISSN">0174-7398</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0174-7398</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: A morphological and cytogenetic analysis of a multifocal angiosarcoma in a typical case of Stewart-Treves syndrome is reported. The morphological analysis indicated differentiation along both blood and lymph vessel endothelium lines. By light and electron microscopy there were areas with well-developed erythrocyte-containing, capillary-like vessels and poorly differentiated areas with abortive vascular formations. In these the endothelium revealed immunoreactivity to factor VIII RAg, binding ofUlex europaeus I andPsophocarpus tetragonolobus agglutinin lectins, Weibel-Palade bodies ultrastructurally and presented a continuous enclosing external lamina and immunoreactivity for laminin and collagen IV, all features of blood-vessel differentiation. There were also lymphangioma-like areas as well as poorly differentiated areas where the immunohistochemical, lectin-binding and ultrastructural features were compatible with a lymph vessel differentiation. Cytogenetic analysis of cultured tumour cells revealed chromosome counts in the diploid region. About 40% of the cells analysed had a normal diploid karyotype. The remaining cells showed a multitude of mainly nonclonal structural alterations; 17 unique marker types resulting from different translocations and deletions were observed. There were also a few cells with clonal numerical deviations showing monosomy 22, monosomy X and trisomy 2 respectively. It is of interest that the losses of chromosome 22 and the X chromosome also have been observed in Kaposi's sarcoma and that the PD-ECGF gene, a novel angiogenetic factor, has been mapped to chromosome 22.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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