[Studies on dynamic of antibodies detected in sera from jirds infected with Brugia malayi before and after treatment].
Identifieur interne : 00DF67 ( Main/Merge ); précédent : 00DF66; suivant : 00DF68[Studies on dynamic of antibodies detected in sera from jirds infected with Brugia malayi before and after treatment].
Auteurs : H. Wu ; Y H LiSource :
- Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases [ 1000-7423 ] ; 1991.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Anticorps antihelminthe, Immunoglobuline G, Immunoglobuline M.
- immunologie : Brugia, Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Filaricides, Nitrofuranes.
- Animaux, Gerbillinae.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antibodies, Helminth, Immunoglobulin G, Immunoglobulin M.
- drug therapy : Elephantiasis, Filarial.
- immunology : Brugia, Elephantiasis, Filarial.
- chemical , therapeutic use : Filaricides, Nitrofurans.
- Animals, Gerbillinae.
Abstract
Indirect immunofluorescent antibody test (IFAT) and immunoenzymatic staining technique (IEST), using frozen section of Brugia malayi and Setaria cervi adult worms, were applied to detect levels of IgG and IgM antibodies in jirds infected with Brugia malayi before and after treatment. Both methods could show the dynamic of antibodies during the course of infection. The peak of IgG and IgM antibodies were at the 12-14th week and 2-6th week after infection respectively. A high correlation was observed between the levels of IgG antibody and the period of infection, whereas the antibody titer had no relation with the density of infection. During 6 months after treatment, the levels of antibodies detected by IFAT and IEST using two antigens decreased to low titre. It is considered that IFAT and IEST using heterologous and homologous antigens could be equally used for the serodiagnosis and the evaluation of cure in filariasis.
PubMed: 2065458
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pubmed:2065458Le document en format XML
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Wu</name><affiliation><nlm:affiliation>Department of Parasitology, Suzhou Medical College.</nlm:affiliation><wicri:noCountry code="subField">Suzhou Medical College</wicri:noCountry></affiliation></author><author><name sortKey="Li, Y H" sort="Li, Y H" uniqKey="Li Y" first="Y H" last="Li">Y H Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:2065458</idno><idno type="pmid">2065458</idno><idno type="wicri:Area/PubMed/Corpus">005C11</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005C11</idno><idno type="wicri:Area/PubMed/Curation">005C11</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005C11</idno><idno type="wicri:Area/PubMed/Checkpoint">005C11</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005C11</idno><idno type="wicri:Area/Ncbi/Merge">003C76</idno><idno type="wicri:Area/Ncbi/Curation">003C76</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C76</idno><idno type="wicri:doubleKey">1000-7423:1991:Wu H:studies:on:dynamic</idno><idno type="wicri:Area/Main/Merge">00DF67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Studies on dynamic of antibodies detected in sera from jirds infected with Brugia malayi before and after treatment].</title><author><name sortKey="Wu, H" sort="Wu, H" uniqKey="Wu H" first="H" last="Wu">H. Wu</name><affiliation><nlm:affiliation>Department of Parasitology, Suzhou Medical College.</nlm:affiliation><wicri:noCountry code="subField">Suzhou Medical College</wicri:noCountry></affiliation></author><author><name sortKey="Li, Y H" sort="Li, Y H" uniqKey="Li Y" first="Y H" last="Li">Y H Li</name></author></analytic><series><title level="j">Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases</title><idno type="ISSN">1000-7423</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filaricides (therapeutic use)</term><term>Gerbillinae</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin M (analysis)</term><term>Nitrofurans (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (analyse)</term><term>Brugia (immunologie)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Gerbillinae</term><term>Immunoglobuline G (analyse)</term><term>Immunoglobuline M (analyse)</term><term>Nitrofuranes (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term><term>Nitrofurans</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Filaricides</term><term>Nitrofuranes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gerbillinae</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Gerbillinae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Indirect immunofluorescent antibody test (IFAT) and immunoenzymatic staining technique (IEST), using frozen section of Brugia malayi and Setaria cervi adult worms, were applied to detect levels of IgG and IgM antibodies in jirds infected with Brugia malayi before and after treatment. Both methods could show the dynamic of antibodies during the course of infection. The peak of IgG and IgM antibodies were at the 12-14th week and 2-6th week after infection respectively. A high correlation was observed between the levels of IgG antibody and the period of infection, whereas the antibody titer had no relation with the density of infection. During 6 months after treatment, the levels of antibodies detected by IFAT and IEST using two antigens decreased to low titre. It is considered that IFAT and IEST using heterologous and homologous antigens could be equally used for the serodiagnosis and the evaluation of cure in filariasis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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