LymphedemaV1, Main, Merge, bibRecord, 00DA52

Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Identifieur interne : 00DA52 ( Main/Merge ); précédent : 00DA51; suivant : 00DA53

Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Auteurs : J. R. Casley-Smith [Australie] ; R. G. Morgan ; N. B. Piller

Source :

The New England journal of medicine [ 0028-4793 ] ; 1993.

RBID : Pascal:94-0003914

Descripteurs français

Pascal (Inist)
- Lymphatique pathologie, Membre inférieur, Membre supérieur, Résultat, Traitement, Homme, Chimiothérapie, Antiinflammatoire, Chirurgie, Lymphoedème, Etude longitudinale, 5,6-Benzo-(α)-pyrone.
Wicri :
- topic : Homme, Chirurgie.

English descriptors

KwdEn :
- Antiinflammatory agent, Chemotherapy, Follow up study, Human, Lower limb, Lymphatic vessel disease, Lymphedema, Result, Surgery, Treatment, Upper limb.

Abstract

Background. Benzopyrones can reduce the volume of high-protein edema fluid by stimulating proteolysis. These compounds provide a method for removing excess protein and its consequent edema and reduce its clinical sequelae, such as chronic inflammation and secondary infections. Methods. We conducted a randomized, double-blind, placebo-controlled, crossover trial of 5,6-benzo-[α]-pyrone in 31 patients with postmastectomy lymphedema of the arm and 21 patients with lymphedema of the leg of various causes. This agent is also known as 56 BaP, 1,2-benzopyrone, and coumarin, although it has no anticoagulant activity. The patients received 400 mg of the active drug or placebo, each for six months. Results. During the placebo period, lymphedema often worsened, especially in the arms

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Pascal:94-0003914

Le document en format XML

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<author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Adelaide, Henry Thomas lab.</s1>
<s2>Adelaide S. Aust. 5001</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
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<country>Australie</country>
<wicri:noRegion>Adelaide S. Aust. 5001</wicri:noRegion>
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<author><name sortKey="Morgan, R G" sort="Morgan, R G" uniqKey="Morgan R" first="R. G." last="Morgan">R. G. Morgan</name>
</author>
<author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone</title>
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<series><title level="j" type="main">The New England journal of medicine</title>
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<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiinflammatory agent</term>
<term>Chemotherapy</term>
<term>Follow up study</term>
<term>Human</term>
<term>Lower limb</term>
<term>Lymphatic vessel disease</term>
<term>Lymphedema</term>
<term>Result</term>
<term>Surgery</term>
<term>Treatment</term>
<term>Upper limb</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Lymphatique pathologie</term>
<term>Membre inférieur</term>
<term>Membre supérieur</term>
<term>Résultat</term>
<term>Traitement</term>
<term>Homme</term>
<term>Chimiothérapie</term>
<term>Antiinflammatoire</term>
<term>Chirurgie</term>
<term>Lymphoedème</term>
<term>Etude longitudinale</term>
<term>5,6-Benzo-(α)-pyrone</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Chirurgie</term>
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<front><div type="abstract" xml:lang="en">Background. Benzopyrones can reduce the volume of high-protein edema fluid by stimulating proteolysis. These compounds provide a method for removing excess protein and its consequent edema and reduce its clinical sequelae, such as chronic inflammation and secondary infections. Methods. We conducted a randomized, double-blind, placebo-controlled, crossover trial of 5,6-benzo-[α]-pyrone in 31 patients with postmastectomy lymphedema of the arm and 21 patients with lymphedema of the leg of various causes. This agent is also known as 56 BaP, 1,2-benzopyrone, and coumarin, although it has no anticoagulant activity. The patients received 400 mg of the active drug or placebo, each for six months. Results. During the placebo period, lymphedema often worsened, especially in the arms</div>
</front>
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<affiliations><list><country><li>Australie</li>
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<tree><noCountry><name sortKey="Morgan, R G" sort="Morgan, R G" uniqKey="Morgan R" first="R. G." last="Morgan">R. G. Morgan</name>
<name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name>
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<country name="Australie"><noRegion><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name>
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Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]-pyrone

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri