Is postoperative radiotherapy beneficial in the management of stage I-II squamous-cell carcinoma of the uterine cervix with negative metastatic nodes and positive parametrial involvement?: A retrospective review of 70 patients.
Identifieur interne : 00D669 ( Main/Merge ); précédent : 00D668; suivant : 00D670Is postoperative radiotherapy beneficial in the management of stage I-II squamous-cell carcinoma of the uterine cervix with negative metastatic nodes and positive parametrial involvement?: A retrospective review of 70 patients.
Auteurs : A. Takamura [Japon] ; J. Mizoe ; T. Arimoto ; T. Kamada ; H. Shirato ; Y. Matsuoka ; M. Tomita ; G. IrieSource :
- Asia-Oceania journal of obstetrics and gynaecology [ 0389-2328 ] ; 1993.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Association thérapeutique (), Carcinome épidermoïde (), Carcinome épidermoïde (radiothérapie), Femelle, Humains, Invasion tumorale, Métastase lymphatique, Période postopératoire, Récidive tumorale locale, Sujet âgé, Taux de survie, Tumeurs du col de l'utérus (), Tumeurs du col de l'utérus (radiothérapie), Études rétrospectives.
- MESH :
- radiothérapie : Carcinome épidermoïde, Tumeurs du col de l'utérus.
- Adulte, Adulte d'âge moyen, Association thérapeutique, Carcinome épidermoïde, Femelle, Humains, Invasion tumorale, Métastase lymphatique, Période postopératoire, Récidive tumorale locale, Sujet âgé, Taux de survie, Tumeurs du col de l'utérus, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Carcinoma, Squamous Cell (radiotherapy), Carcinoma, Squamous Cell (surgery), Combined Modality Therapy (contraindications), Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Postoperative Period, Retrospective Studies, Survival Rate, Uterine Cervical Neoplasms (radiotherapy), Uterine Cervical Neoplasms (surgery).
- MESH :
- contraindications : Combined Modality Therapy.
- radiotherapy : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- surgery : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- Adult, Aged, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Postoperative Period, Retrospective Studies, Survival Rate.
Abstract
Seventy patients having squamous-cell carcinoma of the uterine cervix FIGO Stage I-II with negative lymph nodes and positive parametrial involvement received postoperative radiotherapy following radical hysterectomy and pelvic lymphadenectomy. In 48 patients with microscopic parametrial invasion, the 5-year survival rate was 92%. The other 22 patients with macroscopic parametrial involvement had a 5-year survival rate of 75%. The overall recurrence rate was 13% (9 of 70). The sites of failure were 3 pelvic alone, 5 distant metastases alone, and 1 combined pelvis and para-aortic lymph node. All of those with recurrence were Stage-II cases. The absolute pelvic-control rate was 94.3% (66/70). Fifty-six percent of the patients experienced mild-to-moderate lymphedema. Severe complications requiring surgical intervention were observed in 6 patients (5 bowel obstructions and 1 femoral head fracture). A review of the literature suggests that early carcinoma can be successfully treated by surgery alone. Taking into consideration the risk and benefits involved, postoperative radiotherapy is not recommended for most cases with cervical carcinoma with negative lymph nodes and positive parametrial involvement in the present form, despite excellent local control. However, no definite conclusion can be drawn from this retrospective analysis.
PubMed: 8379861
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Arimoto</name></author><author><name sortKey="Kamada, T" sort="Kamada, T" uniqKey="Kamada T" first="T" last="Kamada">T. Kamada</name></author><author><name sortKey="Shirato, H" sort="Shirato, H" uniqKey="Shirato H" first="H" last="Shirato">H. Shirato</name></author><author><name sortKey="Matsuoka, Y" sort="Matsuoka, Y" uniqKey="Matsuoka Y" first="Y" last="Matsuoka">Y. Matsuoka</name></author><author><name sortKey="Tomita, M" sort="Tomita, M" uniqKey="Tomita M" first="M" last="Tomita">M. Tomita</name></author><author><name sortKey="Irie, G" sort="Irie, G" uniqKey="Irie G" first="G" last="Irie">G. 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Takamura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Asahikawa Kosei Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Asahikawa Kosei Hospital</wicri:regionArea><wicri:noRegion>Asahikawa Kosei Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Mizoe, J" sort="Mizoe, J" uniqKey="Mizoe J" first="J" last="Mizoe">J. Mizoe</name></author><author><name sortKey="Arimoto, T" sort="Arimoto, T" uniqKey="Arimoto T" first="T" last="Arimoto">T. Arimoto</name></author><author><name sortKey="Kamada, T" sort="Kamada, T" uniqKey="Kamada T" first="T" last="Kamada">T. Kamada</name></author><author><name sortKey="Shirato, H" sort="Shirato, H" uniqKey="Shirato H" first="H" last="Shirato">H. Shirato</name></author><author><name sortKey="Matsuoka, Y" sort="Matsuoka, Y" uniqKey="Matsuoka Y" first="Y" last="Matsuoka">Y. Matsuoka</name></author><author><name sortKey="Tomita, M" sort="Tomita, M" uniqKey="Tomita M" first="M" last="Tomita">M. Tomita</name></author><author><name sortKey="Irie, G" sort="Irie, G" uniqKey="Irie G" first="G" last="Irie">G. Irie</name></author></analytic><series><title level="j">Asia-Oceania journal of obstetrics and gynaecology</title><idno type="ISSN">0389-2328</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Carcinoma, Squamous Cell (radiotherapy)</term><term>Carcinoma, Squamous Cell (surgery)</term><term>Combined Modality Therapy (contraindications)</term><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Neoplasm Invasiveness</term><term>Neoplasm Recurrence, Local</term><term>Postoperative Period</term><term>Retrospective Studies</term><term>Survival Rate</term><term>Uterine Cervical Neoplasms (radiotherapy)</term><term>Uterine Cervical Neoplasms (surgery)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique ()</term><term>Carcinome épidermoïde ()</term><term>Carcinome épidermoïde (radiothérapie)</term><term>Femelle</term><term>Humains</term><term>Invasion tumorale</term><term>Métastase lymphatique</term><term>Période postopératoire</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Taux de survie</term><term>Tumeurs du col de l'utérus ()</term><term>Tumeurs du col de l'utérus (radiothérapie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="contraindications" xml:lang="en"><term>Combined Modality Therapy</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Neoplasm Invasiveness</term><term>Neoplasm Recurrence, Local</term><term>Postoperative Period</term><term>Retrospective Studies</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Carcinome épidermoïde</term><term>Femelle</term><term>Humains</term><term>Invasion tumorale</term><term>Métastase lymphatique</term><term>Période postopératoire</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Taux de survie</term><term>Tumeurs du col de l'utérus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Seventy patients having squamous-cell carcinoma of the uterine cervix FIGO Stage I-II with negative lymph nodes and positive parametrial involvement received postoperative radiotherapy following radical hysterectomy and pelvic lymphadenectomy. In 48 patients with microscopic parametrial invasion, the 5-year survival rate was 92%. The other 22 patients with macroscopic parametrial involvement had a 5-year survival rate of 75%. The overall recurrence rate was 13% (9 of 70). The sites of failure were 3 pelvic alone, 5 distant metastases alone, and 1 combined pelvis and para-aortic lymph node. All of those with recurrence were Stage-II cases. The absolute pelvic-control rate was 94.3% (66/70). Fifty-six percent of the patients experienced mild-to-moderate lymphedema. Severe complications requiring surgical intervention were observed in 6 patients (5 bowel obstructions and 1 femoral head fracture). A review of the literature suggests that early carcinoma can be successfully treated by surgery alone. Taking into consideration the risk and benefits involved, postoperative radiotherapy is not recommended for most cases with cervical carcinoma with negative lymph nodes and positive parametrial involvement in the present form, despite excellent local control. However, no definite conclusion can be drawn from this retrospective analysis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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