Cellular immune response studies in bancroftian filariasis.
Identifieur interne : 00BF76 ( Main/Merge ); précédent : 00BF75; suivant : 00BF77Cellular immune response studies in bancroftian filariasis.
Auteurs : J. Regunathan [Inde] ; K. Jayaraman ; P. KalirajSource :
- Journal of helminthology [ 0022-149X ] ; 1997.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Filarioses, Lymphocytes T.
- isolement et purification : Antigènes d'helminthe.
- pharmacologie : Phytohémagglutinine.
- sécrétion : Interleukine-1.
- Activation des lymphocytes, Animaux, Brugia malayi, Humains, Immunité cellulaire.
English descriptors
- KwdEn :
- MESH :
- chemical , isolation & purification : Antigens, Helminth.
- immunology : Filariasis, T-Lymphocytes.
- chemical , pharmacology : Phytohemagglutinins.
- chemical , secretion : Interleukin-1.
- Animals, Brugia malayi, Humans, Immunity, Cellular, Lymphocyte Activation.
Abstract
An attempt was made to identify the filarial specific antigens that are capable of inducing immune response in human filariasis. Lymphocytes were taken from three clinically defined groups living in an endemic area in Madras, namely microfilaraemic (MF) subjects with microfilariae in their blood smear without any clinical symptoms, chronic pathology (CP) individuals with lymphangitis or lymphadenitis in combination with a history of recurrent filarial fevers or lymphoedema, and endemic normals (EN) subjects without microfilariae nor any clinical symptoms of pathology. Lymphocytes from the three groups responded with no significant difference (P = 0.21) in their proliferative index to PPD and PHA, although lymphocytes from MF individuals showed significantly (P < 0.001) less proliferative index to Brugia malayi antigen (BMA) than the CP and EN subjects. This antigen specific cellular unresponsiveness seen in MF patients was not reversed by the addition of recombinant IL-1alpha, IL-1beta, and IFN-gamma, but the addition of sera from EN individuals seemed to restore this unresponsiveness (P < 0.001). The peripheral blood mononuclear cells from MF patients secreted more IL-1 in response to BMA induction than the same from CP and EN individuals. A 58 kDa recombinant protein isolated from a Wuchereria bancrofti genomic library (58 kDa) had mounted a higher proliferative response to lymphocytes from all three groups compared to BMA (P < 0.001) indicating the possible use of recombinant filarial protein to mount immunological responses in filarial patients.
PubMed: 9271478
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004F71
- to stream PubMed, to step Curation: 004F71
- to stream PubMed, to step Checkpoint: 004F71
- to stream Ncbi, to step Merge: 00BA45
- to stream Ncbi, to step Curation: 00BA45
- to stream Ncbi, to step Checkpoint: 00BA45
Links to Exploration step
pubmed:9271478Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cellular immune response studies in bancroftian filariasis.</title><author><name sortKey="Regunathan, J" sort="Regunathan, J" uniqKey="Regunathan J" first="J" last="Regunathan">J. Regunathan</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Biotechnology, Anna University, Madras 600 025, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Biotechnology, Anna University, Madras 600 025</wicri:regionArea><wicri:noRegion>Madras 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Jayaraman, K" sort="Jayaraman, K" uniqKey="Jayaraman K" first="K" last="Jayaraman">K. Jayaraman</name></author><author><name sortKey="Kaliraj, P" sort="Kaliraj, P" uniqKey="Kaliraj P" first="P" last="Kaliraj">P. Kaliraj</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9271478</idno><idno type="pmid">9271478</idno><idno type="wicri:Area/PubMed/Corpus">004F71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004F71</idno><idno type="wicri:Area/PubMed/Curation">004F71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004F71</idno><idno type="wicri:Area/PubMed/Checkpoint">004F71</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004F71</idno><idno type="wicri:Area/Ncbi/Merge">00BA45</idno><idno type="wicri:Area/Ncbi/Curation">00BA45</idno><idno type="wicri:Area/Ncbi/Checkpoint">00BA45</idno><idno type="wicri:doubleKey">0022-149X:1997:Regunathan J:cellular:immune:response</idno><idno type="wicri:Area/Main/Merge">00BF76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cellular immune response studies in bancroftian filariasis.</title><author><name sortKey="Regunathan, J" sort="Regunathan, J" uniqKey="Regunathan J" first="J" last="Regunathan">J. Regunathan</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Biotechnology, Anna University, Madras 600 025, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Biotechnology, Anna University, Madras 600 025</wicri:regionArea><wicri:noRegion>Madras 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Jayaraman, K" sort="Jayaraman, K" uniqKey="Jayaraman K" first="K" last="Jayaraman">K. Jayaraman</name></author><author><name sortKey="Kaliraj, P" sort="Kaliraj, P" uniqKey="Kaliraj P" first="P" last="Kaliraj">P. Kaliraj</name></author></analytic><series><title level="j">Journal of helminthology</title><idno type="ISSN">0022-149X</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Helminth (isolation & purification)</term><term>Brugia malayi</term><term>Filariasis (immunology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Interleukin-1 (secretion)</term><term>Lymphocyte Activation</term><term>Phytohemagglutinins (pharmacology)</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Antigènes d'helminthe (isolement et purification)</term><term>Brugia malayi</term><term>Filarioses (immunologie)</term><term>Humains</term><term>Immunité cellulaire</term><term>Interleukine-1 (sécrétion)</term><term>Lymphocytes T (immunologie)</term><term>Phytohémagglutinine (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filarioses</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Filariasis</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Phytohémagglutinine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phytohemagglutinins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Interleukin-1</term></keywords><keywords scheme="MESH" qualifier="sécrétion" xml:lang="fr"><term>Interleukine-1</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia malayi</term><term>Humans</term><term>Immunity, Cellular</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Brugia malayi</term><term>Humains</term><term>Immunité cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An attempt was made to identify the filarial specific antigens that are capable of inducing immune response in human filariasis. Lymphocytes were taken from three clinically defined groups living in an endemic area in Madras, namely microfilaraemic (MF) subjects with microfilariae in their blood smear without any clinical symptoms, chronic pathology (CP) individuals with lymphangitis or lymphadenitis in combination with a history of recurrent filarial fevers or lymphoedema, and endemic normals (EN) subjects without microfilariae nor any clinical symptoms of pathology. Lymphocytes from the three groups responded with no significant difference (P = 0.21) in their proliferative index to PPD and PHA, although lymphocytes from MF individuals showed significantly (P < 0.001) less proliferative index to Brugia malayi antigen (BMA) than the CP and EN subjects. This antigen specific cellular unresponsiveness seen in MF patients was not reversed by the addition of recombinant IL-1alpha, IL-1beta, and IFN-gamma, but the addition of sera from EN individuals seemed to restore this unresponsiveness (P < 0.001). The peripheral blood mononuclear cells from MF patients secreted more IL-1 in response to BMA induction than the same from CP and EN individuals. A 58 kDa recombinant protein isolated from a Wuchereria bancrofti genomic library (58 kDa) had mounted a higher proliferative response to lymphocytes from all three groups compared to BMA (P < 0.001) indicating the possible use of recombinant filarial protein to mount immunological responses in filarial patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00BF76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 00BF76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:9271478
|texte= Cellular immune response studies in bancroftian filariasis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:9271478" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |