Meta-analysis of age-prevalence patterns in lymphatic filariasis: no decline in microfilaraemia prevalence in older age groups as predicted by models with acquired immunity.
Identifieur interne : 008A04 ( Main/Merge ); précédent : 008A03; suivant : 008A05Meta-analysis of age-prevalence patterns in lymphatic filariasis: no decline in microfilaraemia prevalence in older age groups as predicted by models with acquired immunity.
Auteurs : W A Stolk [Pays-Bas] ; K D Ramaiah ; G J Van Oortmarssen ; P K Das ; J D F. Habbema ; S J De VlasSource :
- Parasitology [ 0031-1820 ] ; 2004.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Afrique subsaharienne (épidémiologie), Animaux, Facteurs de risque, Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (épidémiologie), Humains, Immunité active, Inde (épidémiologie), Mâle, Prévalence, Répartition par âge, Wuchereria bancrofti (immunologie), Études longitudinales.
- MESH :
- immunologie : Filariose lymphatique, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- épidémiologie : Afrique subsaharienne, Filariose lymphatique, Inde.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Facteurs de risque, Femelle, Humains, Immunité active, Mâle, Prévalence, Répartition par âge, Études longitudinales.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adolescent, Adult, Africa South of the Sahara (epidemiology), Age Distribution, Animals, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Female, Humans, Immunity, Active, India (epidemiology), Longitudinal Studies, Male, Middle Aged, Prevalence, Risk Factors, Wuchereria bancrofti (immunology).
- MESH :
- geographic , epidemiology : Africa South of the Sahara, India.
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Age Distribution, Animals, Female, Humans, Immunity, Active, Longitudinal Studies, Male, Middle Aged, Prevalence, Risk Factors.
Abstract
The role of acquired immunity in lymphatic filariasis is uncertain. Assuming that immunity against new infections develops gradually with accumulated experience of infection, models predict a decline in prevalence after teenage or early adulthood. A strong indication for acquired immunity was found in longitudinal data from Pondicherry, India, where Mf prevalence was highest around the age of 20 and declined thereafter. We reviewed published studies from India and Subsaharan Africa to investigate whether their age-prevalence patterns support the models with acquired immunity. By comparing prevalence levels in 2 adult age groups we tested whether prevalence declined at older age. For India, comparison of age groups 20-39 and 40+ revealed a significant decline in only 6 out of 53 sites, whereas a significant increase occurred more often (10 sites). Comparison of older age groups provided no indication that a decline would start at a later age. Results from Africa were even more striking, with many more significant increases than declines, irrespective of the age groups compared. The occurrence of a decline was not related to the overall Mf prevalence and seems to be a chance finding. We conclude that there is no evidence of a general age-prevalence pattern that would correspond to the acquired immunity models. The Pondicherry study is an exceptional situation that may have guided us in the wrong direction.
PubMed: 15552405
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Habbema</name></author><author><name sortKey="De Vlas, S J" sort="De Vlas, S J" uniqKey="De Vlas S" first="S J" last="De Vlas">S J De Vlas</name></author></analytic><series><title level="j">Parasitology</title><idno type="ISSN">0031-1820</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Africa South of the Sahara (epidemiology)</term><term>Age Distribution</term><term>Animals</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Immunity, Active</term><term>India (epidemiology)</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Risk Factors</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Afrique subsaharienne (épidémiologie)</term><term>Animaux</term><term>Facteurs de risque</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Immunité active</term><term>Inde (épidémiologie)</term><term>Mâle</term><term>Prévalence</term><term>Répartition par âge</term><term>Wuchereria bancrofti (immunologie)</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa South of the Sahara</term><term>India</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique subsaharienne</term><term>Filariose lymphatique</term><term>Inde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Animals</term><term>Female</term><term>Humans</term><term>Immunity, Active</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Immunité active</term><term>Mâle</term><term>Prévalence</term><term>Répartition par âge</term><term>Études longitudinales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of acquired immunity in lymphatic filariasis is uncertain. Assuming that immunity against new infections develops gradually with accumulated experience of infection, models predict a decline in prevalence after teenage or early adulthood. A strong indication for acquired immunity was found in longitudinal data from Pondicherry, India, where Mf prevalence was highest around the age of 20 and declined thereafter. We reviewed published studies from India and Subsaharan Africa to investigate whether their age-prevalence patterns support the models with acquired immunity. By comparing prevalence levels in 2 adult age groups we tested whether prevalence declined at older age. For India, comparison of age groups 20-39 and 40+ revealed a significant decline in only 6 out of 53 sites, whereas a significant increase occurred more often (10 sites). Comparison of older age groups provided no indication that a decline would start at a later age. Results from Africa were even more striking, with many more significant increases than declines, irrespective of the age groups compared. The occurrence of a decline was not related to the overall Mf prevalence and seems to be a chance finding. We conclude that there is no evidence of a general age-prevalence pattern that would correspond to the acquired immunity models. The Pondicherry study is an exceptional situation that may have guided us in the wrong direction.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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