Role of lymphangiogenesis in epithelial ovarian cancer
Identifieur interne : 007A32 ( Main/Merge ); précédent : 007A31; suivant : 007A33Role of lymphangiogenesis in epithelial ovarian cancer
Auteurs : S S Sundar [Royaume-Uni] ; H. Zhang [Royaume-Uni] ; P. Brown [Royaume-Uni] ; S. Manek [Royaume-Uni] ; C. Han [Royaume-Uni] ; K. Kaur [Royaume-Uni] ; M F L. Charnock [Royaume-Uni] ; D. Jackson [Royaume-Uni] ; T S Ganesan [Royaume-Uni]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2006.
Abstract
We investigated the significance of lymphatic count, vascular count and angiogenic growth factors using immunohistochemistry in 108 tumour specimens of epithelial ovarian cancer with antibodies to lymphatic vessel endothelial hyaluronan receptor (LYVE-1), platelet endothelial cell adhesion molecule CD31, vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) in epithelial ovarian cancer to understand the pathogenesis of metastasis in ovarian cancer. The effect of prognostic variables on progression-free and overall survival was assessed. On multivariate analysis, bulky residual disease after surgery was the best prognostic indicator (
Url:
DOI: 10.1038/sj.bjc.6603144
PubMed: 16685274
PubMed Central: 2361318
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000109
- to stream Pmc, to step Curation: 000109
- to stream Pmc, to step Checkpoint: 003C33
- to stream Ncbi, to step Merge: 002225
- to stream Ncbi, to step Curation: 002225
- to stream Ncbi, to step Checkpoint: 002225
Links to Exploration step
PMC:2361318Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of lymphangiogenesis in epithelial ovarian cancer</title>
<author><name sortKey="Sundar, S S" sort="Sundar, S S" uniqKey="Sundar S" first="S S" last="Sundar">S S Sundar</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Ovarian Cancer Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, H" sort="Zhang, H" uniqKey="Zhang H" first="H" last="Zhang">H. Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Ovarian Cancer Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Cellular Pathology, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manek, S" sort="Manek, S" uniqKey="Manek S" first="S" last="Manek">S. Manek</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Cellular Pathology, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Han, C" sort="Han, C" uniqKey="Han C" first="C" last="Han">C. Han</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Churchill Hospital, Headington</institution>
Oxford OX3 7LF,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaur, K" sort="Kaur, K" uniqKey="Kaur K" first="K" last="Kaur">K. Kaur</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Churchill Hospital, Headington</institution>
Oxford OX3 7LF,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Charnock, M F L" sort="Charnock, M F L" uniqKey="Charnock M" first="M F L" last="Charnock">M F L. Charnock</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jackson, D" sort="Jackson, D" uniqKey="Jackson D" first="D" last="Jackson">D. Jackson</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ganesan, T S" sort="Ganesan, T S" uniqKey="Ganesan T" first="T S" last="Ganesan">T S Ganesan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Ovarian Cancer Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">16685274</idno>
<idno type="pmc">2361318</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361318</idno>
<idno type="RBID">PMC:2361318</idno>
<idno type="doi">10.1038/sj.bjc.6603144</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">000109</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000109</idno>
<idno type="wicri:Area/Pmc/Curation">000109</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000109</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003C33</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003C33</idno>
<idno type="wicri:Area/Ncbi/Merge">002225</idno>
<idno type="wicri:Area/Ncbi/Curation">002225</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002225</idno>
<idno type="wicri:doubleKey">0007-0920:2006:Sundar S:role:of:lymphangiogenesis</idno>
<idno type="wicri:Area/Main/Merge">007A32</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of lymphangiogenesis in epithelial ovarian cancer</title>
<author><name sortKey="Sundar, S S" sort="Sundar, S S" uniqKey="Sundar S" first="S S" last="Sundar">S S Sundar</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Ovarian Cancer Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, H" sort="Zhang, H" uniqKey="Zhang H" first="H" last="Zhang">H. Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Ovarian Cancer Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Cellular Pathology, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manek, S" sort="Manek, S" uniqKey="Manek S" first="S" last="Manek">S. Manek</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Cellular Pathology, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Han, C" sort="Han, C" uniqKey="Han C" first="C" last="Han">C. Han</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Churchill Hospital, Headington</institution>
Oxford OX3 7LF,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaur, K" sort="Kaur, K" uniqKey="Kaur K" first="K" last="Kaur">K. Kaur</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Churchill Hospital, Headington</institution>
Oxford OX3 7LF,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Charnock, M F L" sort="Charnock, M F L" uniqKey="Charnock M" first="M F L" last="Charnock">M F L. Charnock</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jackson, D" sort="Jackson, D" uniqKey="Jackson D" first="D" last="Jackson">D. Jackson</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ganesan, T S" sort="Ganesan, T S" uniqKey="Ganesan T" first="T S" last="Ganesan">T S Ganesan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Ovarian Cancer Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital</institution>
Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
<idno type="eISSN">1532-1827</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We investigated the significance of lymphatic count, vascular count and angiogenic growth factors using immunohistochemistry in 108 tumour specimens of epithelial ovarian cancer with antibodies to lymphatic vessel endothelial hyaluronan receptor (LYVE-1), platelet endothelial cell adhesion molecule CD31, vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) in epithelial ovarian cancer to understand the pathogenesis of metastasis in ovarian cancer. The effect of prognostic variables on progression-free and overall survival was assessed. On multivariate analysis, bulky residual disease after surgery was the best prognostic indicator (<italic>P</italic>
<0.001) for progression-free and overall survival (<italic>P</italic>
<0.001). Lymphatic count was statistically significant as a prognostic factor for progression-free (<italic>P</italic>
=0.05) and overall survival (<italic>P</italic>
=0.04). However, lymphatic count did not impact on survival curves. No correlation was found between lymphatic count and age, histological subtype, FIGO stage or residual disease. Vascular count, VEGF or TP expressions were not significant in either analysis. Lymphatic spread may be significant in aiding metastases in ovarian cancer but requires other biological factors to act in conjunction, as it does not have clearcut prognostic significance. Dissemination of ovarian cancer does not occur primarily through vascular or lymphatic routes but may occur through direct intraperitoneal spread of disease.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007A32 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 007A32 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:2361318 |texte= Role of lymphangiogenesis in epithelial ovarian cancer }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:16685274" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |