Lymphangiogenesis in development and disease
Identifieur interne : 007907 ( Main/Merge ); précédent : 007906; suivant : 007908Lymphangiogenesis in development and disease
Auteurs : Ruediger Liersch [Allemagne] ; Michael Detmar [Suisse]Source :
- Thrombosis and haemostasis [ 0340-6245 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cancer.
English descriptors
- KwdEn :
Abstract
The lymphatic vascular system plays an important role in the maintenance of fluid homeostasis, in the afferent immune response, in the intestinal lipid uptake and in the metastatic spread of malignant cells.The recent discovery of specific markers and growth factors for lymphatic endothelium and the establishment of genetic mouse models with impairment of lymphatic function have provided novel insights into the molecular control of the lymphatic system in physiology and in embryonic development. They have also identified molecular pathways whose mutation-al inactivation leads to human diseases associated with lymphedema. Moreover, the lymphatic system plays a major role in chronic inflammatory diseases and in transplant rejection. Importantly, malignant tumors can directly promote lymphangiogenesis within the primary tumor and in draining lymph nodes, leading to enhanced cancer metastasis to lymph nodes and beyond. Based upon these findings, novel therapeutic strategies are currently being developed that aim at inhibiting or promoting the formation and function of lymphatic vessels in disease.
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- to stream PascalFrancis, to step Curation: 000512
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Pascal:07-0393202Le document en format XML
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<country>Allemagne</country>
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<wicri:noRegion>University Hospital Muenster</wicri:noRegion>
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<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute of Pharmaceutical Sciences, Swiss Federal Institute ofTechnology, ETH Zurich</s1>
<s2>Zurich</s2>
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<country>Suisse</country>
<placeName><settlement type="city">Zurich</settlement>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancer</term>
<term>Endothelium</term>
<term>Inflammation</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic system</term>
<term>Lymphedema</term>
<term>Malignant tumor</term>
<term>Metastasis</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Lymphoedème</term>
<term>Système lymphatique</term>
<term>Endothélium</term>
<term>Tumeur maligne</term>
<term>Inflammation</term>
<term>Métastase</term>
<term>Lymphangiogenèse</term>
<term>Cancer</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cancer</term>
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<front><div type="abstract" xml:lang="en">The lymphatic vascular system plays an important role in the maintenance of fluid homeostasis, in the afferent immune response, in the intestinal lipid uptake and in the metastatic spread of malignant cells.The recent discovery of specific markers and growth factors for lymphatic endothelium and the establishment of genetic mouse models with impairment of lymphatic function have provided novel insights into the molecular control of the lymphatic system in physiology and in embryonic development. They have also identified molecular pathways whose mutation-al inactivation leads to human diseases associated with lymphedema. Moreover, the lymphatic system plays a major role in chronic inflammatory diseases and in transplant rejection. Importantly, malignant tumors can directly promote lymphangiogenesis within the primary tumor and in draining lymph nodes, leading to enhanced cancer metastasis to lymph nodes and beyond. Based upon these findings, novel therapeutic strategies are currently being developed that aim at inhibiting or promoting the formation and function of lymphatic vessels in disease.</div>
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<country name="Suisse"><region name="Canton de Zurich"><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
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