Yellow nail syndrome : not a genetic disorder? Eleven new cases and a review of the literature
Identifieur interne : 007879 ( Main/Merge ); précédent : 007878; suivant : 007880Yellow nail syndrome : not a genetic disorder? Eleven new cases and a review of the literature
Auteurs : S. R. Hoque [Royaume-Uni] ; S. Mansour [Royaume-Uni] ; Peter Mortimer (dermatologue) [Royaume-Uni]Source :
- British journal of dermatology : (1951) [ 0007-0963 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique.
English descriptors
- KwdEn :
Abstract
Background Yellow nail syndrome (YNS) is characterized by the triad of characteristic nail changes, chronic respiratory disorders and primary lymphoedema. Over 100 cases have been published, most of which have been sporadic. Despite this, YNS is classified as a dominantly inherited lymphoedema with variable expression. There have been only a few published reports where a positive family history (FH) has been documented in cases of YNS. Objectives To conduct a retrospective survey investigating the genetic basis of YNS. Methods The notes of 11 patients diagnosed with YNS were examined for documentation of a positive FH, and in addition a postal questionnaire was sent to these patients. Results Only one of the 11 patients had a relevant FH. In addition, four patients had complete recovery of their nail changes. Conclusions This is the first retrospective study of YNS to document clear remission of nail changes. The lack of a positive FH in the majority of patients in our study, the late onset of the disease and recovery of nail changes in our patients suggest that YNS may not be primarily a genetic disease as it is currently classified.
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Pascal:07-0273501Le document en format XML
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Mansour</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>SW Thames Regional Genetics Unit, St George's Hospital, University of London</s1><s2>London SW17 0RE</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P. S." last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Dermatology Unit, Cardiac and Vascular Sciences, St George's Hospital, University of London</s1><s2>London SW17 0RE</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0273501</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0273501 INIST</idno><idno type="RBID">Pascal:07-0273501</idno><idno type="wicri:Area/PascalFrancis/Corpus">000473</idno><idno type="wicri:Area/PascalFrancis/Curation">000487</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000435</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000435</idno><idno type="wicri:doubleKey">0007-0963:2007:Hoque S:yellow:nail:syndrome</idno><idno type="wicri:Area/Main/Merge">007879</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Yellow nail syndrome : not a genetic disorder? Eleven new cases and a review of the literature</title><author><name sortKey="Hoque, S R" sort="Hoque, S R" uniqKey="Hoque S" first="S. R." last="Hoque">S. R. Hoque</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Dermatology, St Helier Hospital</s1><s2>Carshalton, Surrey SM5 1AA</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Carshalton, Surrey SM5 1AA</wicri:noRegion></affiliation></author><author><name sortKey="Mansour, S" sort="Mansour, S" uniqKey="Mansour S" first="S." last="Mansour">S. Mansour</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>SW Thames Regional Genetics Unit, St George's Hospital, University of London</s1><s2>London SW17 0RE</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P. S." last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Dermatology Unit, Cardiac and Vascular Sciences, St George's Hospital, University of London</s1><s2>London SW17 0RE</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></analytic><series><title level="j" type="main">British journal of dermatology : (1951)</title><title level="j" type="abbreviated">Br. j. dermatol. : (1951)</title><idno type="ISSN">0007-0963</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of dermatology : (1951)</title><title level="j" type="abbreviated">Br. j. dermatol. : (1951)</title><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dermatology</term><term>Disorder</term><term>Genetics</term><term>Lymphedema</term><term>Review</term><term>Yellow nail syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Ongle jaune syndrome</term><term>Lymphoedème</term><term>Génétique</term><term>Désordre</term><term>Article synthèse</term><term>Dermatologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Yellow nail syndrome (YNS) is characterized by the triad of characteristic nail changes, chronic respiratory disorders and primary lymphoedema. Over 100 cases have been published, most of which have been sporadic. Despite this, YNS is classified as a dominantly inherited lymphoedema with variable expression. There have been only a few published reports where a positive family history (FH) has been documented in cases of YNS. Objectives To conduct a retrospective survey investigating the genetic basis of YNS. Methods The notes of 11 patients diagnosed with YNS were examined for documentation of a positive FH, and in addition a postal questionnaire was sent to these patients. Results Only one of the 11 patients had a relevant FH. In addition, four patients had complete recovery of their nail changes. Conclusions This is the first retrospective study of YNS to document clear remission of nail changes. The lack of a positive FH in the majority of patients in our study, the late onset of the disease and recovery of nail changes in our patients suggest that YNS may not be primarily a genetic disease as it is currently classified.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Hoque, S R" sort="Hoque, S R" uniqKey="Hoque S" first="S. R." last="Hoque">S. R. Hoque</name></noRegion><name sortKey="Mansour, S" sort="Mansour, S" uniqKey="Mansour S" first="S." last="Mansour">S. Mansour</name><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P. S." last="Mortimer">Peter Mortimer (dermatologue)</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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