Regulation of lymphatic capillary regeneration by interstitial flow in skin.
Identifieur interne : 007251 ( Main/Merge ); précédent : 007250; suivant : 007252Regulation of lymphatic capillary regeneration by interstitial flow in skin.
Auteurs : Jeremy Goldman [États-Unis] ; Kelly A. Conley ; Alisha Raehl ; Dona M. Bondy ; Bronislaw Pytowski ; Melody A. Swartz ; Joseph M. Rutkowski ; David B. Jaroch ; Emily L. OngstadSource :
- American journal of physiology. Heart and circulatory physiology [ 0363-6135 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type C (administration et posologie), Femelle, Lymphangiogenèse (), Lymphangiogenèse (physiologie), Noeuds lymphatiques (), Noeuds lymphatiques (physiologie), Peau (), Phénomènes physiologiques de la peau (), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Régénération (), Régénération (physiologie), Souris, Souris de lignée BALB C, Vaisseaux lymphatiques (), Vaisseaux lymphatiques (physiologie).
- MESH :
- administration et posologie : Facteur de croissance endothéliale vasculaire de type C.
- métabolisme : Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiologie : Lymphangiogenèse, Noeuds lymphatiques, Régénération, Vaisseaux lymphatiques.
- Animaux, Femelle, Lymphangiogenèse, Noeuds lymphatiques, Peau, Phénomènes physiologiques de la peau, Régénération, Souris, Souris de lignée BALB C, Vaisseaux lymphatiques.
English descriptors
- KwdEn :
- Animals, Female, Lymph Nodes (blood supply), Lymph Nodes (drug effects), Lymph Nodes (physiology), Lymphangiogenesis (drug effects), Lymphangiogenesis (physiology), Lymphatic Vessels (drug effects), Lymphatic Vessels (physiology), Mice, Mice, Inbred BALB C, Regeneration (drug effects), Regeneration (physiology), Skin (blood supply), Skin (drug effects), Skin Physiological Phenomena (drug effects), Vascular Endothelial Growth Factor C (administration & dosage), Vascular Endothelial Growth Factor Receptor-3 (metabolism).
- MESH :
- chemical , administration & dosage : Vascular Endothelial Growth Factor C.
- blood supply : Lymph Nodes, Skin.
- drug effects : Lymph Nodes, Lymphangiogenesis, Lymphatic Vessels, Regeneration, Skin, Skin Physiological Phenomena.
- chemical , metabolism : Vascular Endothelial Growth Factor Receptor-3.
- physiology : Lymph Nodes, Lymphangiogenesis, Lymphatic Vessels, Regeneration.
- Animals, Female, Mice, Mice, Inbred BALB C.
Abstract
Decreased interstitial flow (IF) in secondary lymphedema is coincident with poor physiological lymphatic regeneration. However, both the existence and direction of causality between IF and lymphangiogenesis remain unclear. This is primarily because the role of IF and its importance relative to the action of the prolymphangiogenic growth factor vascular endothelial growth factor (VEGF)-C (which signals primarily through its receptor VEGFR-3) are poorly understood. To clarify this, we explored the cooperative roles of VEGFR-3 and IF in a mouse model of lymphangiogenesis in regenerating skin. Specifically, a region of lymphangiogenesis was created by substituting a portion of mouse tail skin with a collagen gel within which lymphatic capillaries completely regenerate over a period of 60 days. The relative importance of IF and VEGF-C signaling were evaluated by either inhibiting VEGFR-3 signaling with antagonistic antibodies or by reducing IF. In some cases, VEGF-C signaling was then increased with exogenous protein. To clarify the role of IF, the distribution of endogenous matrix metalloproteinases (MMPs) and VEGF-C within the regenerating region was determined. It was found that inhibition of either VEGFR-3 or IF suppressed endogenous lymphangiogenesis. Reduction of IF was found to decrease lymphatic migration and transport of endogenous MMP and VEGF-C through the regenerating region. Therapeutic VEGF-C administration restored lymphangiogenesis following inhibition of VEGFR-3 but did not increase lymphangiogenesis following inhibition of IF. These results identify IF as an important regulator of the pro-lymphangiogenic action of VEGF-C.
DOI: 10.1152/ajpheart.01011.2006
PubMed: 17189348
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pubmed:17189348Le document en format XML
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Conley</name></author><author><name sortKey="Raehl, Alisha" sort="Raehl, Alisha" uniqKey="Raehl A" first="Alisha" last="Raehl">Alisha Raehl</name></author><author><name sortKey="Bondy, Dona M" sort="Bondy, Dona M" uniqKey="Bondy D" first="Dona M" last="Bondy">Dona M. Bondy</name></author><author><name sortKey="Pytowski, Bronislaw" sort="Pytowski, Bronislaw" uniqKey="Pytowski B" first="Bronislaw" last="Pytowski">Bronislaw Pytowski</name></author><author><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A" last="Swartz">Melody A. Swartz</name></author><author><name sortKey="Rutkowski, Joseph M" sort="Rutkowski, Joseph M" uniqKey="Rutkowski J" first="Joseph M" last="Rutkowski">Joseph M. Rutkowski</name></author><author><name sortKey="Jaroch, David B" sort="Jaroch, David B" uniqKey="Jaroch D" first="David B" last="Jaroch">David B. Jaroch</name></author><author><name sortKey="Ongstad, Emily L" sort="Ongstad, Emily L" uniqKey="Ongstad E" first="Emily L" last="Ongstad">Emily L. 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Conley</name></author><author><name sortKey="Raehl, Alisha" sort="Raehl, Alisha" uniqKey="Raehl A" first="Alisha" last="Raehl">Alisha Raehl</name></author><author><name sortKey="Bondy, Dona M" sort="Bondy, Dona M" uniqKey="Bondy D" first="Dona M" last="Bondy">Dona M. Bondy</name></author><author><name sortKey="Pytowski, Bronislaw" sort="Pytowski, Bronislaw" uniqKey="Pytowski B" first="Bronislaw" last="Pytowski">Bronislaw Pytowski</name></author><author><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A" last="Swartz">Melody A. Swartz</name></author><author><name sortKey="Rutkowski, Joseph M" sort="Rutkowski, Joseph M" uniqKey="Rutkowski J" first="Joseph M" last="Rutkowski">Joseph M. Rutkowski</name></author><author><name sortKey="Jaroch, David B" sort="Jaroch, David B" uniqKey="Jaroch D" first="David B" last="Jaroch">David B. Jaroch</name></author><author><name sortKey="Ongstad, Emily L" sort="Ongstad, Emily L" uniqKey="Ongstad E" first="Emily L" last="Ongstad">Emily L. Ongstad</name></author></analytic><series><title level="j">American journal of physiology. Heart and circulatory physiology</title><idno type="ISSN">0363-6135</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Female</term><term>Lymph Nodes (blood supply)</term><term>Lymph Nodes (drug effects)</term><term>Lymph Nodes (physiology)</term><term>Lymphangiogenesis (drug effects)</term><term>Lymphangiogenesis (physiology)</term><term>Lymphatic Vessels (drug effects)</term><term>Lymphatic Vessels (physiology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Regeneration (drug effects)</term><term>Regeneration (physiology)</term><term>Skin (blood supply)</term><term>Skin (drug effects)</term><term>Skin Physiological Phenomena (drug effects)</term><term>Vascular Endothelial Growth Factor C (administration & dosage)</term><term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteur de croissance endothéliale vasculaire de type C (administration et posologie)</term><term>Femelle</term><term>Lymphangiogenèse ()</term><term>Lymphangiogenèse (physiologie)</term><term>Noeuds lymphatiques ()</term><term>Noeuds lymphatiques (physiologie)</term><term>Peau ()</term><term>Phénomènes physiologiques de la peau ()</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Régénération ()</term><term>Régénération (physiologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaisseaux lymphatiques ()</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Lymph Nodes</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymph Nodes</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels</term><term>Regeneration</term><term>Skin</term><term>Skin Physiological Phenomena</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Noeuds lymphatiques</term><term>Régénération</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph Nodes</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels</term><term>Regeneration</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Lymphangiogenèse</term><term>Noeuds lymphatiques</term><term>Peau</term><term>Phénomènes physiologiques de la peau</term><term>Régénération</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaisseaux lymphatiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Decreased interstitial flow (IF) in secondary lymphedema is coincident with poor physiological lymphatic regeneration. However, both the existence and direction of causality between IF and lymphangiogenesis remain unclear. This is primarily because the role of IF and its importance relative to the action of the prolymphangiogenic growth factor vascular endothelial growth factor (VEGF)-C (which signals primarily through its receptor VEGFR-3) are poorly understood. To clarify this, we explored the cooperative roles of VEGFR-3 and IF in a mouse model of lymphangiogenesis in regenerating skin. Specifically, a region of lymphangiogenesis was created by substituting a portion of mouse tail skin with a collagen gel within which lymphatic capillaries completely regenerate over a period of 60 days. The relative importance of IF and VEGF-C signaling were evaluated by either inhibiting VEGFR-3 signaling with antagonistic antibodies or by reducing IF. In some cases, VEGF-C signaling was then increased with exogenous protein. To clarify the role of IF, the distribution of endogenous matrix metalloproteinases (MMPs) and VEGF-C within the regenerating region was determined. It was found that inhibition of either VEGFR-3 or IF suppressed endogenous lymphangiogenesis. Reduction of IF was found to decrease lymphatic migration and transport of endogenous MMP and VEGF-C through the regenerating region. Therapeutic VEGF-C administration restored lymphangiogenesis following inhibition of VEGFR-3 but did not increase lymphangiogenesis following inhibition of IF. These results identify IF as an important regulator of the pro-lymphangiogenic action of VEGF-C.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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