Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis
Identifieur interne : 006E79 ( Main/Merge ); précédent : 006E78; suivant : 006E80Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis
Auteurs : T. Nagasaka [Japon] ; T. Koyama [Japon] ; K. Matsumura [Japon] ; K. R. Chen [Japon]Source :
- Clinical and Experimental Dermatology [ 0307-6938 ] ; 2008-11.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Cellules épithélioïdes, Dermatoses faciales, Granulome, Histiocytes, Lymphoedème, Peau, Rosacée, Vaisseaux lymphatiques.
- Humains, Mâle, Sujet âgé, Syndrome.
English descriptors
- KwdEn :
- MESH :
- immunology : Epithelioid Cells, Facial Dermatoses, Granuloma, Histiocytes, Lymphatic Vessels, Lymphedema, Rosacea, Skin.
- Aged, Humans, Male, Syndrome.
Abstract
Morbihan disease is a rare complication of rosacea, characterized by persistent lymphoedema on the upper half of the face, occurring during the chronic clinical course of rosacea. This refractory condition has been also designated as ‘rosacea lymphoedema’ and ‘solid persistent facial oedema of rosacea’. We report a patient with Morbihan disease showing persistent lymphoedema on the upper half of the face accompanied by unique histological findings of striking dermal dilated lymphatics and damage of the lymphatics at the site of the adjacent epithelioid cell granulomas, with histiocytes bulging into the lymphatic lumen. The marked epithelioid cell granulomas forming around dermal lymphatic vessels with subsequent lymphatic damage and luminal obstruction by histiocytic infiltration may account for the development of lymphoedema in this patient.
Url:
DOI: 10.1111/j.1365-2230.2008.02892.x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003163
- to stream Istex, to step Curation: 003163
- to stream Istex, to step Checkpoint: 001029
- to stream PubMed, to step Corpus: 003200
- to stream PubMed, to step Curation: 003200
- to stream PubMed, to step Checkpoint: 003200
- to stream Ncbi, to step Merge: 002E36
- to stream Ncbi, to step Curation: 002E36
- to stream Ncbi, to step Checkpoint: 002E36
Links to Exploration step
ISTEX:6A4091D9E0978EBD2E5EEB3E36FA0EEEED05F006Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis</title><author><name sortKey="Nagasaka, T" sort="Nagasaka, T" uniqKey="Nagasaka T" first="T." last="Nagasaka">T. Nagasaka</name></author><author><name sortKey="Koyama, T" sort="Koyama, T" uniqKey="Koyama T" first="T." last="Koyama">T. Koyama</name></author><author><name sortKey="Matsumura, K" sort="Matsumura, K" uniqKey="Matsumura K" first="K." last="Matsumura">K. Matsumura</name></author><author><name sortKey="Chen, K R" sort="Chen, K R" uniqKey="Chen K" first="K. R." last="Chen">K. R. Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6A4091D9E0978EBD2E5EEB3E36FA0EEEED05F006</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1365-2230.2008.02892.x</idno><idno type="url">https://api.istex.fr/document/6A4091D9E0978EBD2E5EEB3E36FA0EEEED05F006/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003163</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003163</idno><idno type="wicri:Area/Istex/Curation">003163</idno><idno type="wicri:Area/Istex/Checkpoint">001029</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001029</idno><idno type="wicri:doubleKey">0307-6938:2008:Nagasaka T:persistent:lymphoedema:in</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:18627384</idno><idno type="wicri:Area/PubMed/Corpus">003200</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003200</idno><idno type="wicri:Area/PubMed/Curation">003200</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003200</idno><idno type="wicri:Area/PubMed/Checkpoint">003200</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003200</idno><idno type="wicri:Area/Ncbi/Merge">002E36</idno><idno type="wicri:Area/Ncbi/Curation">002E36</idno><idno type="wicri:Area/Ncbi/Checkpoint">002E36</idno><idno type="wicri:Area/Main/Merge">006E79</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis</title><author><name sortKey="Nagasaka, T" sort="Nagasaka, T" uniqKey="Nagasaka T" first="T." last="Nagasaka">T. Nagasaka</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Koyama, T" sort="Koyama, T" uniqKey="Koyama T" first="T." last="Koyama">T. Koyama</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Matsumura, K" sort="Matsumura, K" uniqKey="Matsumura K" first="K." last="Matsumura">K. Matsumura</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Chen, K R" sort="Chen, K R" uniqKey="Chen K" first="K. R." last="Chen">K. R. Chen</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical and Experimental Dermatology</title><title level="j" type="alt">CLINICAL EXPERIMENTAL DERMATOLOGY</title><idno type="ISSN">0307-6938</idno><idno type="eISSN">1365-2230</idno><imprint><biblScope unit="vol">33</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="764">764</biblScope><biblScope unit="page" to="767">767</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-11">2008-11</date></imprint><idno type="ISSN">0307-6938</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0307-6938</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Epithelioid Cells (immunology)</term><term>Facial Dermatoses (immunology)</term><term>Granuloma (immunology)</term><term>Histiocytes (immunology)</term><term>Humans</term><term>Lymphatic Vessels (immunology)</term><term>Lymphedema (immunology)</term><term>Male</term><term>Rosacea (immunology)</term><term>Skin (immunology)</term><term>Syndrome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules épithélioïdes (immunologie)</term><term>Dermatoses faciales (immunologie)</term><term>Granulome (immunologie)</term><term>Histiocytes (immunologie)</term><term>Humains</term><term>Lymphoedème (immunologie)</term><term>Mâle</term><term>Peau (immunologie)</term><term>Rosacée (immunologie)</term><term>Sujet âgé</term><term>Syndrome</term><term>Vaisseaux lymphatiques (immunologie)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules épithélioïdes</term><term>Dermatoses faciales</term><term>Granulome</term><term>Histiocytes</term><term>Lymphoedème</term><term>Peau</term><term>Rosacée</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Epithelioid Cells</term><term>Facial Dermatoses</term><term>Granuloma</term><term>Histiocytes</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Rosacea</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Male</term><term>Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Morbihan disease is a rare complication of rosacea, characterized by persistent lymphoedema on the upper half of the face, occurring during the chronic clinical course of rosacea. This refractory condition has been also designated as ‘rosacea lymphoedema’ and ‘solid persistent facial oedema of rosacea’. We report a patient with Morbihan disease showing persistent lymphoedema on the upper half of the face accompanied by unique histological findings of striking dermal dilated lymphatics and damage of the lymphatics at the site of the adjacent epithelioid cell granulomas, with histiocytes bulging into the lymphatic lumen. The marked epithelioid cell granulomas forming around dermal lymphatic vessels with subsequent lymphatic damage and luminal obstruction by histiocytic infiltration may account for the development of lymphoedema in this patient.</div></front></TEI><double doi="10.1111/j.1365-2230.2008.02892.x"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis</title><author><name sortKey="Nagasaka, T" sort="Nagasaka, T" uniqKey="Nagasaka T" first="T." last="Nagasaka">T. Nagasaka</name></author><author><name sortKey="Koyama, T" sort="Koyama, T" uniqKey="Koyama T" first="T." last="Koyama">T. Koyama</name></author><author><name sortKey="Matsumura, K" sort="Matsumura, K" uniqKey="Matsumura K" first="K." last="Matsumura">K. Matsumura</name></author><author><name sortKey="Chen, K R" sort="Chen, K R" uniqKey="Chen K" first="K. R." last="Chen">K. R. Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6A4091D9E0978EBD2E5EEB3E36FA0EEEED05F006</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1365-2230.2008.02892.x</idno><idno type="url">https://api.istex.fr/document/6A4091D9E0978EBD2E5EEB3E36FA0EEEED05F006/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003163</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003163</idno><idno type="wicri:Area/Istex/Curation">003163</idno><idno type="wicri:Area/Istex/Checkpoint">001029</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001029</idno><idno type="wicri:doubleKey">0307-6938:2008:Nagasaka T:persistent:lymphoedema:in</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis</title><author><name sortKey="Nagasaka, T" sort="Nagasaka, T" uniqKey="Nagasaka T" first="T." last="Nagasaka">T. Nagasaka</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Koyama, T" sort="Koyama, T" uniqKey="Koyama T" first="T." last="Koyama">T. Koyama</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Matsumura, K" sort="Matsumura, K" uniqKey="Matsumura K" first="K." last="Matsumura">K. Matsumura</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Chen, K R" sort="Chen, K R" uniqKey="Chen K" first="K. R." last="Chen">K. R. Chen</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical and Experimental Dermatology</title><title level="j" type="alt">CLINICAL EXPERIMENTAL DERMATOLOGY</title><idno type="ISSN">0307-6938</idno><idno type="eISSN">1365-2230</idno><imprint><biblScope unit="vol">33</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="764">764</biblScope><biblScope unit="page" to="767">767</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-11">2008-11</date></imprint><idno type="ISSN">0307-6938</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0307-6938</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Morbihan disease is a rare complication of rosacea, characterized by persistent lymphoedema on the upper half of the face, occurring during the chronic clinical course of rosacea. This refractory condition has been also designated as ‘rosacea lymphoedema’ and ‘solid persistent facial oedema of rosacea’. We report a patient with Morbihan disease showing persistent lymphoedema on the upper half of the face accompanied by unique histological findings of striking dermal dilated lymphatics and damage of the lymphatics at the site of the adjacent epithelioid cell granulomas, with histiocytes bulging into the lymphatic lumen. The marked epithelioid cell granulomas forming around dermal lymphatic vessels with subsequent lymphatic damage and luminal obstruction by histiocytic infiltration may account for the development of lymphoedema in this patient.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis.</title><author><name sortKey="Nagasaka, T" sort="Nagasaka, T" uniqKey="Nagasaka T" first="T" last="Nagasaka">T. Nagasaka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Saiseikai Central Hospital, Tokyo, Japan. takeshingsk@n07.itscom.net</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Koyama, T" sort="Koyama, T" uniqKey="Koyama T" first="T" last="Koyama">T. Koyama</name></author><author><name sortKey="Matsumura, K" sort="Matsumura, K" uniqKey="Matsumura K" first="K" last="Matsumura">K. Matsumura</name></author><author><name sortKey="Chen, K R" sort="Chen, K R" uniqKey="Chen K" first="K R" last="Chen">K R Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18627384</idno><idno type="pmid">18627384</idno><idno type="doi">10.1111/j.1365-2230.2008.02892.x</idno><idno type="wicri:Area/PubMed/Corpus">003200</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003200</idno><idno type="wicri:Area/PubMed/Curation">003200</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003200</idno><idno type="wicri:Area/PubMed/Checkpoint">003200</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003200</idno><idno type="wicri:Area/Ncbi/Merge">002E36</idno><idno type="wicri:Area/Ncbi/Curation">002E36</idno><idno type="wicri:Area/Ncbi/Checkpoint">002E36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis.</title><author><name sortKey="Nagasaka, T" sort="Nagasaka, T" uniqKey="Nagasaka T" first="T" last="Nagasaka">T. Nagasaka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Saiseikai Central Hospital, Tokyo, Japan. takeshingsk@n07.itscom.net</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Saiseikai Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Koyama, T" sort="Koyama, T" uniqKey="Koyama T" first="T" last="Koyama">T. Koyama</name></author><author><name sortKey="Matsumura, K" sort="Matsumura, K" uniqKey="Matsumura K" first="K" last="Matsumura">K. Matsumura</name></author><author><name sortKey="Chen, K R" sort="Chen, K R" uniqKey="Chen K" first="K R" last="Chen">K R Chen</name></author></analytic><series><title level="j">Clinical and experimental dermatology</title><idno type="eISSN">1365-2230</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Epithelioid Cells (immunology)</term><term>Facial Dermatoses (immunology)</term><term>Granuloma (immunology)</term><term>Histiocytes (immunology)</term><term>Humans</term><term>Lymphatic Vessels (immunology)</term><term>Lymphedema (immunology)</term><term>Male</term><term>Rosacea (immunology)</term><term>Skin (immunology)</term><term>Syndrome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules épithélioïdes (immunologie)</term><term>Dermatoses faciales (immunologie)</term><term>Granulome (immunologie)</term><term>Histiocytes (immunologie)</term><term>Humains</term><term>Lymphoedème (immunologie)</term><term>Mâle</term><term>Peau (immunologie)</term><term>Rosacée (immunologie)</term><term>Sujet âgé</term><term>Syndrome</term><term>Vaisseaux lymphatiques (immunologie)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules épithélioïdes</term><term>Dermatoses faciales</term><term>Granulome</term><term>Histiocytes</term><term>Lymphoedème</term><term>Peau</term><term>Rosacée</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Epithelioid Cells</term><term>Facial Dermatoses</term><term>Granuloma</term><term>Histiocytes</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Rosacea</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Male</term><term>Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Morbihan disease is a rare complication of rosacea, characterized by persistent lymphoedema on the upper half of the face, occurring during the chronic clinical course of rosacea. This refractory condition has been also designated as 'rosacea lymphoedema' and 'solid persistent facial oedema of rosacea'. We report a patient with Morbihan disease showing persistent lymphoedema on the upper half of the face accompanied by unique histological findings of striking dermal dilated lymphatics and damage of the lymphatics at the site of the adjacent epithelioid cell granulomas, with histiocytes bulging into the lymphatic lumen. The marked epithelioid cell granulomas forming around dermal lymphatic vessels with subsequent lymphatic damage and luminal obstruction by histiocytic infiltration may account for the development of lymphoedema in this patient.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006E79 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006E79 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:6A4091D9E0978EBD2E5EEB3E36FA0EEEED05F006
|texte= Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis
}}
| This area was generated with Dilib version V0.6.31. |  |