Non-Peptide Small Molecule Regulators of Lymphangiogenesis
Identifieur interne : 006213 ( Main/Merge ); précédent : 006212; suivant : 006214Non-Peptide Small Molecule Regulators of Lymphangiogenesis
Auteurs : Changge Fang ; Marta Aparicio Miguel ; Ingalill Avis ; Alfredo Martinez ; Enrique Zudaire ; Frank CuttittaSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2009.
Abstract
Adrenomedullin (AM) and gastrin releasing peptide (GRP) are neuroendocrine peptides that have been previously implicated as regulators of angiogenesis and lymphangiogenesis. Using an immortalized human dermal microvascular lymphatic endothelial cell line stably transfected with red fluorescent protein (LEC/RFP), we demonstrate the ability of AM and GRP to augment tube formation complexity of this target cell in a dose-dependent manner. Maximum tube density was initiated at 1n
Url:
DOI: 10.1089/lrb.2009.0033
PubMed: 20143917
PubMed Central: 2843547
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003054
- to stream Pmc, to step Curation: 003053
- to stream Pmc, to step Checkpoint: 003655
- to stream Ncbi, to step Merge: 003911
- to stream Ncbi, to step Curation: 003911
- to stream Ncbi, to step Checkpoint: 003911
Links to Exploration step
PMC:2843547Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-Peptide Small Molecule Regulators of Lymphangiogenesis</title>
<author><name sortKey="Fang, Changge" sort="Fang, Changge" uniqKey="Fang C" first="Changge" last="Fang">Changge Fang</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Miguel, Marta Aparicio" sort="Miguel, Marta Aparicio" uniqKey="Miguel M" first="Marta Aparicio" last="Miguel">Marta Aparicio Miguel</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Avis, Ingalill" sort="Avis, Ingalill" uniqKey="Avis I" first="Ingalill" last="Avis">Ingalill Avis</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martinez, Alfredo" sort="Martinez, Alfredo" uniqKey="Martinez A" first="Alfredo" last="Martinez">Alfredo Martinez</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zudaire, Enrique" sort="Zudaire, Enrique" uniqKey="Zudaire E" first="Enrique" last="Zudaire">Enrique Zudaire</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cuttitta, Frank" sort="Cuttitta, Frank" uniqKey="Cuttitta F" first="Frank" last="Cuttitta">Frank Cuttitta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20143917</idno>
<idno type="pmc">2843547</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843547</idno>
<idno type="RBID">PMC:2843547</idno>
<idno type="doi">10.1089/lrb.2009.0033</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">003054</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003054</idno>
<idno type="wicri:Area/Pmc/Curation">003053</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003053</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003655</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003655</idno>
<idno type="wicri:Area/Ncbi/Merge">003911</idno>
<idno type="wicri:Area/Ncbi/Curation">003911</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003911</idno>
<idno type="wicri:doubleKey">1539-6851:2009:Fang C:non:peptide:small</idno>
<idno type="wicri:Area/Main/Merge">006213</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Non-Peptide Small Molecule Regulators of Lymphangiogenesis</title>
<author><name sortKey="Fang, Changge" sort="Fang, Changge" uniqKey="Fang C" first="Changge" last="Fang">Changge Fang</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Miguel, Marta Aparicio" sort="Miguel, Marta Aparicio" uniqKey="Miguel M" first="Marta Aparicio" last="Miguel">Marta Aparicio Miguel</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Avis, Ingalill" sort="Avis, Ingalill" uniqKey="Avis I" first="Ingalill" last="Avis">Ingalill Avis</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martinez, Alfredo" sort="Martinez, Alfredo" uniqKey="Martinez A" first="Alfredo" last="Martinez">Alfredo Martinez</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zudaire, Enrique" sort="Zudaire, Enrique" uniqKey="Zudaire E" first="Enrique" last="Zudaire">Enrique Zudaire</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cuttitta, Frank" sort="Cuttitta, Frank" uniqKey="Cuttitta F" first="Frank" last="Cuttitta">Frank Cuttitta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Lymphatic Research and Biology</title>
<idno type="ISSN">1539-6851</idno>
<idno type="eISSN">1557-8585</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Adrenomedullin (AM) and gastrin releasing peptide (GRP) are neuroendocrine peptides that have been previously implicated as regulators of angiogenesis and lymphangiogenesis. Using an immortalized human dermal microvascular lymphatic endothelial cell line stably transfected with red fluorescent protein (LEC/RFP), we demonstrate the ability of AM and GRP to augment tube formation complexity of this target cell in a dose-dependent manner. Maximum tube density was initiated at 1n<italic>M</italic>
for both peptides, and as concentrations exceeded 10 n<italic>M</italic>
a decrease in tube formation was noted, hence following a classic rise/fall biological response curve. In addition, we show that appropriate small molecule mimetics to neutralizing monoclonal antibodies of AM or GRP, at 1 μ<italic>M</italic>
concentration, can function to either inhibit (antagonist) or enhance (super agonist) peptide-induced tube formation of LEC/RFP. Our small molecule reagents by themselves have no activity, but in the presence of their respective peptides can mediate a positive or negative response, hence the super agonist designation. These compounds represent new regulatory drugs of the lymphatic system with possible patient application in the clinical management of edema and metastatic disease.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006213 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006213 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:2843547 |texte= Non-Peptide Small Molecule Regulators of Lymphangiogenesis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:20143917" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |