Serveur d'exploration sur le lymphœdème

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Nanoparticles in Sentinel Lymph Node Assessment in Breast Cancer

Identifieur interne : 005792 ( Main/Merge ); précédent : 005791; suivant : 005793

Nanoparticles in Sentinel Lymph Node Assessment in Breast Cancer

Auteurs : Laura Johnson ; Geoff Charles-Edwards ; Michael Douek

Source :

RBID : PMC:3840452

Abstract

The modern management of the axilla in breast cancer relies on surgery for accurate staging of disease and identifying those patients at risk who would benefit from adjuvant chemotherapy. The introduction of sentinel lymph node biopsy has revolutionized axillary surgery, but still involves a surgical procedure with associated morbidity in many patients with no axillary involvement. Nanotechnology encompasses a broad spectrum of scientific specialities, of which nanomedicine is one. The potential use of dual-purpose nanoprobes could enable imaging the axilla simultaneous identification and treatment of metastatic disease. Whilst most applications of nanomedicine are still largely in the laboratory phase, some potential applications are currently undergoing clinical evaluation for translation from the bench to the bedside. This is an exciting new area of research where scientific research may become a reality.


Url:
DOI: 10.3390/cancers2041884
PubMed: 24281206
PubMed Central: 3840452

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:3840452

Le document en format XML

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<nlm:aff id="af1-cancers-02-01884">Department of Research Oncology, Kings College London, 3rd Floor Bermondsey Wing, Guy’s Hospital, London, SE1 9RT, UK; E-Mail:
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<nlm:aff id="af2-cancers-02-01884">Department of Medical Physics, Guys and St Thomas’ NHS Foundation Trust, 4th Floor Lambeth Wing, St Thomas’ Hospital, London, SE1 7EH, UK; E-Mail:
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<nlm:aff id="af1-cancers-02-01884">Department of Research Oncology, Kings College London, 3rd Floor Bermondsey Wing, Guy’s Hospital, London, SE1 9RT, UK; E-Mail:
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<p>The modern management of the axilla in breast cancer relies on surgery for accurate staging of disease and identifying those patients at risk who would benefit from adjuvant chemotherapy. The introduction of sentinel lymph node biopsy has revolutionized axillary surgery, but still involves a surgical procedure with associated morbidity in many patients with no axillary involvement. Nanotechnology encompasses a broad spectrum of scientific specialities, of which nanomedicine is one. The potential use of dual-purpose nanoprobes could enable imaging the axilla simultaneous identification and treatment of metastatic disease. Whilst most applications of nanomedicine are still largely in the laboratory phase, some potential applications are currently undergoing clinical evaluation for translation from the bench to the bedside. This is an exciting new area of research where scientific research may become a reality.</p>
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